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| 1 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 2 | Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification显示文摘变形前列腺癌症当前是医不好的。转移被认为在 nonmetastatic 前列腺癌症织物从变化导致特定的驾驶转移的基因的表示,导致设置了在运动的变形过程的激活的下游的基因的串联。如此的基因能潜在地为疾病的改进管理用作有效治疗学的目标。他们能被基因表示侧面的比较分析识别导出病人变形并且指出基因出现的 nonmetastatic 前列腺癌症纸巾改变了表示,由决定如此的基因的 silencing 是否能导致变形性质的抑制列在后面。在这条途径遇到的各种各样的障碍被讨论,包括(i) 对的需要临床上相关, nonmetastatic 和变形前列腺癌症纸巾象 patients’ 的异种皮移植那样;前列腺癌症经由 subrenal 囊 grafting 技术发展了并且(ii ) 在为鉴定的当前可得到的方法论的限制掌握规章的基因。 | Yan Ting Chiang Peter W Gout Colin C Collins Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 3 | Single amino-acid substitutions in recombinant bovine prolactin that markedly reduce its mitogenic activity in Nb2 cell cultures显示文摘 | Luck D N Huyer M Gout P W | 1991 | Mol Endocrino1991，15，： | 1 |
| 4 | Current and prospective applications of metal ion-protein binding 显示文摘 | Ueda E K M Gout P W Morgantia L | 2003 | J Chromatogr A2003，988，： | 1 |
| 5 | Current and prospective applications ofmetal ion protein binding显示文摘 | Ueda E K M Gout P W Morganti L | 2003 | Journal of Chromatography A2003，988，： | 1 |
| 6 | Recombinant bovine prolactin:loss of bioactivity after single amino acid deletions from putative helical regions显示文摘 | Luck D N Gout P W Kelsay K | 1990 | Mol Endocrinol1990，4，7： | 1 |
| 7 | Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis显示文摘 | Tourbah A Stivevnart JL Gout O | 1999 | Neurology1999，53，： | 1 |
| 8 | Changes in Kennedy pathway intermediates associated with increased triacylglycerol synthesis in oil-seed rape 显示文摘 | Perry H J Bligny R Gout E | 1999 | Phytochemistry1999，52，5： | 1 |
| 9 | Matrix metal- loproteinase expression in cardiac myocytes following myocardial infarction in the rabbit显示文摘 | ROMANIC A BURNS KURTIS C GOUT B | 2001 | Life Sci2001，68，7： | 1 |
| 10 | Lipid peroxidation and defense related enzymes in maize infected by Rhizoctonia solani 显示文摘 | Sharma RR Gout HN Bom K K | 2002 | Indian-Phytopathology2002，55，4： | 1 |
| 11 | Segmentation under geometrical conditions using geodesic active contours and interpolation using level set methods显示文摘 | Gout C Guyader C L Vese L | 2005 | Numer Algorithms2005，39，： | 1 |
| 12 | Current and pro- spective applications of metal ion-protein binding 显示文摘 | UEDA E GOUT P MORGANTI L | 2003 | Journal of Chromatography A2003，988，1： | 1 |
| 13 | The human NUPR1/P8gene is transcriptionally activated by transforming growth factor beta viathe SMAD signalling pathway 显示文摘 | Pommier RM Gout J Vincent DF | 2012 | Biochem J2012，445，2： | 1 |
| 14 | Matrix metalloprotein- ase expression incardiac myocytes following myocardial infarction in the rabbit显示文摘 | Romanic AM Burns - Kurtis CL Gout B | 2001 | Life Sci2001，68，7： | 1 |
| 15 | Phos- phate (Pi) starvation effect on the eytosolic Pi concentration and Pi exchanges across the tonoplast in plant cells:an in vivo 31p _ nuclear magnetic resonance study using methylphosphonate as a Pi analog 显示文摘 | Pratt J Boisson A -M Gout E Bligny R Douce R | 2009 | Plant Physiology2009，151，3： | 1 |
| 16 | Hi (11) based immobilised metalion affinity chromatography of iecombiimnt human prolactin from periplasmic Escherichia coli extracts显示文摘 | Ueda EK Gout PW Morganti L | 2005 | Journal of Chromatography A2005，922，： | 1 |
| 17 | Common human T cell leukemia virus type 1 (HTLV - 1) integration sites in serebrospinal fluid and blood lymphocytes of patients with HTLV - 1 - associated myelopathy/tropical spastic paraparesis indicate that HTLV - 1 crosses the blood - brain barrier via clonal HTLV - 1 - infected cells显示文摘 | Cavrois M Gessain A Gout O | 2000 | J Infect Dis2000，182，： | 1 |
| 18 | Mannitol synthesis in higher plants:evidence for the role and characterization of NADH-dependent mannose-phosphate reductase显示文摘 | Loescher W H Tyson R H Gout E | 1992 | Plant Physiol1992，98，： | 1 |
| 19 | Molecular char- acterization and polymorphism of MinLml, a minisatel- lite from the phytopathogenic ascomycete Leptosphaeria maculans显示文摘 | Attard A Gourgues M Gout L | 2001 | Current Genetics2001，40，1： | 1 |
| 20 | Anovel inhibitory proteinin adipose tissue, the aldo - keto reductase AKR1B7 : its rolein adipogcnesis 显示文摘 | Tirard J Gout J Lefrancois - Martinez AM | 2007 | Endocrinology2007，148，5： | 1 |
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