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	题名	作者	年代	出处	被引量
1	Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘	AGATHA C GEMMA L NURIA R	1999	Bichem Biophys Ras Commun1999，260，50：	1
2	Acid volatile sulfide determination in sediments using elemental analyzer with thermal conductivity detector 显示文摘	HaidiD F Roser R Gemma R	1999	Talanta1999，48，：	1
3	Phytosterols: physiologic and metabolic aspects related to cholesteol - lowering properties 显示文摘	Gemma B Miguel A C Magda R	2008	Nutrition Research2008，，28：	1
4	Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)显示文摘	Kokubo Y Gemma A Noro R	2005	Br J Cancer2005，92，9：	1
5	Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls显示文摘	Gemma V Jose BC Belen R	2005	Hum Reprod2005，20，11：	1
6	A modified procedure for staining roots to detect VA mycorrhizas显示文摘	KOSKE R E GEMMA J N	1989	Mycological Research1989，92，4：	1
7	Mycobacterium tuberculosis-Induced CXCR4 and Chemokine Expression Leads to preferential X4 HIV-1 replication in human macrophages显示文摘	Yoshihiko Hoshino Doris B Tes Gemma R	2004	Immunology2004，172，：	1
8	Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability.	Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas	2021	Engineering2021，7，10：	1
9	Gefitinib 0ressa) sensitive lung cancer cell lines show phesphorylation of Akt without ligand stimulation 显示文摘	NORO R GEMMA A KOSAIHIREA S	2006	BMC Cancer2006，6，9：	1
10	Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)显示文摘	KOKUBO Y GEMMA A NORO R	2005	BrJ Cancer2005，92，9：	1
11	Modelling a Reliability System Governed by Discrete Phase-type Distributions显示文摘	Juan E R C Rafael P 0 Gemma F V	2008	Reliability Engineering and System Safety2008，93，：	1
12	Photoelectrochemical study of nitrogen-doped titanium dioxide for water oxidation显示文摘	GEMMA R T LINDGREN T LU J	2004	J Phys Chem B2004，108，：	1
13	Antimicrobial and an- tioxidant activities of unripe papaya显示文摘	JAMES A O LIBRADO A S GEMMA M R	1993	Life Sci1993，17，：	1
14	Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefetinib (Iressa)显示文摘	Kokubo Y Gemma A Noro R	2005	Br J Cancer2005，92，9：	1
15	Phase I/II study of paclitaxel+carboplatin for refrac-tory or recurrent non-smallcell lung cancer显示文摘	Gemma A Seike M Kosaihira S Minegishi Y Noro R NaraM	2006	Anticancer Res2006，26，：	1
16	Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to ge- fitinib (IRESSA) 显示文摘	Kokubo Y Gemma A Noro R	2005	Br J Cancer2005，92，9：	1
17	Vitamin D and incidence of diabetes: a prospective cohort study显示文摘	Inmaeulada G M Gemma R M Sonsoles M	2012	Clin Nutr2012，31，4：	1
18	Human mitocbondrial transcription factor A (mtTFA): gene structure and characterization of related pseudogenes显示文摘	Aurelio R Hector E Gemma G	2002	Gene2002，291，12：	1
19	A modified procedure for staining roots to detect VA mycorrhizas显示文摘	Koske R E Gemma J N	1989	Mycol Res1989，92，4：	1
20	Serotonergic activation stimulates the pituitaryadrenal axis and alters interleukin-1 mRNA expression in rat brain 显示文摘	Gemma C Imeri L Opp M R	2003	Psychoneuroendocrinology2003，28，7：	1

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