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| 1 | Transplantation of low-power laser-irradiated olfactory ensheathing cells to promote repair of spinal cord injury in rats显示文摘BACKGROUND:Previous studies have demonstrated that low-power laser(LPL) irradiation can promote the regeneration of peripheral nerves and central nerves,as well as influence cellular proliferation.Therefore,it is thought to be a potential treatment for spinal cord injury. OBJECTIVE:Utilizing histological observations and behavioral evaluations,the aim of this study was to investigate the influence of transplanted olfactory ensheathing cells(OECs),irradiated by LPL,on functional repair of rats following transversal spinal cord injury. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at the animal experimental center in the First Affiliated Hospital of Xinjiang Medical University between January 2007 and February 2008. MATERIALS:A total of 52 Sprague Dawley rats were included in this experiment.Twelve rats were used to harvest OECs,some of which were irradiated by LPL on days 3,5,and 7 in culture. The remaining 40 rats were used to establish T_(12) complete spinal cord transection injury. DMEM/F12 medium was purchased from Sigma,USA,Fluorogold was provided by Chemicon, USA,and the LY/JG650-D500-16 low-power laser was produced by Xi'an Lingyue Electromechanical Science And Technology Co.,Ltd.,China. METHODS:The successful rat models were randomly divided into three groups:OEC transplantation,LPL-irradiated OEC transplantation,and control.These animals were microinjected with OEC suspension,LPL-irradiated OEC suspension,and DMEM/F12 medium (10μL) respectively 4 weeks after spinal cord was completely transected at the T_(12) level. MAIN OUTCOME MEASURES:Spinal cord injury was observed using hematoxylin-eosin staining. Expression of nerve growth factor receptor p75 and glial fibrillary acidic protein were determined using immunohistochemical staining.Regeneration of spinal nerve fibers in rats was assayed by Fluorogold retrograde labeling method.Basso,Beattie and Bresnahan(BBB) scores were used to evaluate motor functions of rat lower limbs. RESULTS:Structural disturbances were observed following spinal cord injury in each group,and a large amount of scar tissue covered the broken ends,accompanied by porosis and inflammatory cell infiltration.Following OEC transplantation,the distal end connected to the proximal end.nerve growth factor receptor p75 and glial fibrillary acidic protein immunohistochemistry revealed positive OECs in the cephalad and caudal area of rats that received LPL-irradiated OEC transplantation.In the OECs group,only glial fibrillary acidic protein staining was observed.No staining was found in the control group.Neural fibers labeled with Fluorogold extended across the lesion area and into the cephalad and caudal area in the OECs and LPL-irradiated OECs groups, but were not present in the control group.BBB scores revealed statistically significant differences among the three groups(P<0.05):OECs irradiated by LPL group>OECs group>control group. CONCLUSION:Transplantation of OECs and LPL-irradiated OECs promoted functional repair in the injured spinal cord of rats,although LPL-irradiated OECs resulted in greater beneficial effects. | Haoxian Chen Xinfeng Zheng Weibin Sheng Qin Wei Tao Jiang Gele Jin | 2009 | Neural Regeneration Research2009，4，3： | 3 |
| 2 | Traceability from a European perspective显示文摘 | F. Schw?gele | 2005 | Meat Science2005，，1： | 2 |
| 3 | Changing trends of incidence and prognosis of thyroid carcinoma in lower Franconia, Germany, from 1981 - 1995显示文摘 | FARAHATI J GELING M M)~DER U | 2004 | Thyroid2004，14，2： | 1 |
| 4 | Should 5-hydroxytryptamine-3 receptor antagonists be administered beyond 24 hours after chemotherapy to prevent delayed emesis Systematic reevaluation of clinical evidence and drug cost implications显示文摘 | Geling O Eichler HG | 2005 | J Clin Oncol2005，23，6： | 1 |
| 5 | Primary central nervous system lymphomas(PCNSL):MRI response criteria revised显示文摘 | Küker W N?gele T Thiel E | | 0，，07： | 1 |
| 6 | Development of visible and near infrared camouflage textile materials 显示文摘 | RUBEZIENE Vitalija MINKUVIENE Gele BALTUSNIKAITE Julija | 2009 | Materials Science2009，15，2： | 1 |
| 7 | High ICAM-1 gene expression in pulmonary fibroblasts of COPD pa- tients: a reflection of an enhanced immunological function显示文摘 | Zand-Voort A Van der Gele YM Jonker MR | 2006 | Eur Respir J2006，28，1： | 1 |
| 8 | Ventricular arrhythmias following exposure of failing hearts to oxidative stress in vitro显示文摘 | Brigadeau F Gele P Marquie C | 2005 | Cardiovasc Electrophysiol2005，16，6： | 1 |
| 9 | Changing trends of incidence and prognosis of thyroid carcinoma in lower Franconia,Germany,from 1981-1995显示文摘 | Farahati J Geling M Mader U | 2004 | Thyroid2004，14，2： | 1 |
| 10 | Development of a 3Dpigmented skin model to evaluate RNAi-induced depigmentation 显示文摘 | Van Gele M Geusens B Speeckaert R | 2011 | Exp Dermatol2011，20，9： | 1 |
| 11 | Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment 显示文摘 | Deplanque D Gele P Petrault O | 2003 | J Neurosci2003，23，15： | 1 |
| 12 | Griscelli syndrome:a model system to study vesicular trafficking显示文摘 | Van Gele M Dynoodt P Lambert J | 2009 | Pigment Cell Melanoma Res2009，22，： | 1 |
| 13 | The PPAR activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy显示文摘 | Brigadeau F Gele P Wibaux M | 2007 | J Cardiovase Pharmacol2007，49，6： | 1 |
| 14 | The PPARα activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia - induced cardiomyopathy 显示文摘 | Brigadeau F Gele P Wibaux M | 2007 | J Cardiovasc Pharmacol2007，49，6： | 1 |
| 15 | Quantitative reverse pranscriptase-polymerase chain reaction measured expression of MDR1 and MRP in primary breast carcinoma显示文摘 | Dexter DW Reddy RK Geles KG | 1998 | Clin Cancer Res1998，4，6： | 1 |
| 16 | Influence of social capital on farmer household income gap:total effect and structural effect显示文摘Based on the survey data of typical villages in Shaanxi Province,China,the effect of social capital on the income gap of farmers' households was analyzed using the Shapley value of the total amount of social capital and the social capital structure.The results show the following:first,social capital can expand the household income gap,and the effect of this index on the household income gap is 7.54%.Second,the indexes of the social capital dimension can expand the household income gap,and the structural effects of the household income gap on social networks,social trust,and social participation are 3.17%,3.64%,and 0.65%,respectively.Third,no dimension of the path is the same as the effect on the household income gap. | Geling Wang Qian Lu | 2016 | Chinese Journal of Population,Resources and Environment2016，16，1： | 1 |
| 17 | Delayed cerebrovascular protective effect of lipopolysaccharide in parallel to brain ischemic tolerance 显示文摘 | Bastide M Gele P Petrault O | 2003 | J Cereb Blood Flow Metab2003，23，4： | 1 |
| 18 | Vcntricltlar arrhythmias following exposure of failing hearts to oxidative stress in vitro显示文摘 | Brigadeau F Gele P Marquic C | 2005 | Cardiovase Electrophysiol2005，16，6： | 1 |
| 19 | Simulator for advanced fighter radar EPM development 显示文摘 | DiFilippo D Geling G Currie G | 2001 | IEE Proc Radar Sonar Navig2001，3，148： | 1 |
| 20 | Improved ship detection with airborne polarimetric SAR data 显示文摘 | C Liu P W Vachon G W Geling | 2005 | Canadian Journal of Remote Sensing2005，31，1： | 1 |
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