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| 1 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 2 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 3 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 4 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 5 | Clay swelling and formation permeability reductions induced by a nonionic surfactant 显示文摘 | Gardner K H Arias M S | 2000 | Environ Sci Technol2000，34，1： | 2 |
| 6 | Neutral models for the analysis of broad-scale landscape pattern显示文摘 | Gardner R H Mime B T Turner M G | 1987 | Landscape Ecology1987，1，1： | 2 |
| 7 | Clay swelling and formation permeability reductions induced by a nonionic surfactant显示文摘 | GARDNER K H ARIAS M S | 2000 | Environ Sci Technol2000，34，： | 1 |
| 8 | Intelligent vapour discrimination using a composite 12-element sensor army显示文摘 | SHURMER H V GARDNER J W | 1990 | Sensors and Actuators1990，，1： | 1 |
| 9 | Variable pore size, variable chemical functionality, and an example of reactivity within porous phenylaeetylene silver salts 显示文摘 | Kiang Y H Gardner G B Lobkovsky E B | 1999 | J Am Chem Soc1999，121，： | 1 |
| 10 | Modeling hydrology and reactive transport in roads: the effect of cracks, the edge, and contaminant properties显示文摘 | Apul D S Gardner K H Eighmy T T | 2007 | Science Direct Waste Management2007，27，： | 1 |
| 11 | Formation velocity and density-The diagnostic basis for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，6： | 1 |
| 12 | Steady-state planar ablative flow显示文摘 | Manheimer W M Colombant D G Gardner J H | 1982 | PhysFluids1982，25，： | 1 |
| 13 | Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds显示文摘 | l-lakkinen L Koivisto L Gardner H | 2004 | Am J Pathol2004，164，1： | 1 |
| 14 | An examination of response-surface methodologies for uncertainty analysis in assessment models 显示文摘 | Downing D J Gardner R H Hoffman F O | 1985 | Technometrics1985，27，： | 1 |
| 15 | Direct evaporation from soil under a row crop canopy显示文摘 | Shawcroft R W Gardner H R | 1983 | Agricultural Meteorology1983，28，3： | 1 |
| 16 | Why would anyone become an expert显示文摘 | GARDNER H | | 0，，09： | 1 |
| 17 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 18 | The application of discrimination techniques to alcohols and tobaccos using tin oxide sensor显示文摘 | SHURMER H V GARDNER J W | 1989 | Sensors and Actuators1989，18，： | 1 |
| 19 | Probabilistic modeling of one-dimensional water movement and leaching from highway embankments containing secondary materials显示文摘 | Apul D S Gardner K H Eighmy T T | 2005 | Environmental Engineering Science2005，22，2： | 1 |
| 20 | Indices of landscape pattern 显示文摘 | O'Neill R V Krummel J R Gardner R H | 1988 | Landscape Ecology1988，，： | 1 |
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