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| 1 | Delaying surgery after neoadjuvant chemoradiotherapy improves prognosis of rectal cancer显示文摘AIM To investigate the prognostic effect of a delayed interval between neoadjuvant chemoradiotherapy(CRT) and surgery in locally advanced rectal cancer.METHODS We evaluated 87 patients with locally advanced mid-or distal rectal cancer undergoing total mesorectal excision following an interval period after neoadjuvant CRT at ?i?li Hamidiye Etfal Training and Research Hospital,Istanbul between January 2009 and January 2014.Patients were divided into two groups according to the intervalbefore surgery: < 8 wk(group Ⅰ) and ≥ 8 wk(group Ⅱ).Data related to patients,cancer characteristics and pathological examination were collected and analyzed.RESULTS When the distribution of timing between group Ⅰ(n = 45) and group Ⅱ(n = 42) was viewed,comparison of interval periods(median ± SD) of groups showed a significant difference of as 5 ± 1.28 wk in group Ⅰ and 10.1 ± 2.2 wk in group Ⅱ(P < 0.001).The median follow-up period for all patients was 34.5(9.9-81) mo.group Ⅱ had significantly higher rates of pathological complete response(p CR) than group Ⅰ had(19% vs 8.9%,P = 0.002).Rate of tumor regression grade(TRG) poor response was 44.4% in group Ⅰ and 9.5% in group Ⅱ(P < 0.002).A poor pathological response was associated with worse disease-free survival(P = 0.009).The interval time did not show any association with local recurrence(P = 0.79).CONCLUSION Delaying the neoadjuvant CRT-surgery interval may provide nodal down-staging,improve p CR rate,and decrease the rate of TRG poor response. | Mehmet Mihmanli Esin Kabul Gürbulak Ismail Ethem Akgün Mustafa Fevzi Celayir Pinar Yazici Deniz Tuncel Tuba Tülin Bek Ayhan Oz Sinan Omeroglu | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 3 |
| 2 | Degradation of cyanogenic glycosides of bitter apricot seeds(Prunus armeniaca)by endogenous and added enzymas as affected by heat treatments and particle size显示文摘 | Tuncel G Nout MJR Brimer L | 1998 | Food Chemistry1998，63，1： | 1 |
| 3 | The effect of vacuum packaging and gaseous atmosphere on microbial growth in tripe显示文摘 | GOKTAN D TUNCEL G UNLUTURK A | 1988 | Meat Science1988，24，： | 1 |
| 4 | Hypoglycetnic activity of Urtica pilulifera in streptozotocin-diabetic rats显示文摘 | Kavalali G Tuncel H G ksel S | 2003 | J Ethnopharmacol2003，84，23： | 1 |
| 5 | Preoperative emotional states in patients with breast canner and postoperative pain 显示文摘 | Ozalp G Sarioglu R Tuncel G | 2003 | Acta Anaesthesiol Scand2003，47，1： | 1 |
| 6 | Rain water chemistry in Ankara, Turkey显示文摘 | TUNCEL G S UNGOR S | 1996 | Atmos Environ1996，30，15： | 1 |
| 7 | 显示文摘 | TUNCEL D STEINKE J H G | 1999 | Chem Commun1999，16，： | 1 |
| 8 | Effects ofhyaluronic acid- car-boxymethylcellulose membrane on extraneural adhesion for marion and peripheral nerve regeneration显示文摘 | Adanali G Verdi M Tuncel A etal | 2003 | JReconstr Microsurg2003，19，1： | 1 |
| 9 | Preoperative emotional states in patients with breast cancer and postoperative pain显示文摘 | Ozalp G Sarioglu R Tuncel G | 2003 | Acta Anaesthesiol Scand2003，47，1： | 1 |
| 10 | Epidural ropivacaine or sufentanil - ropivacaine infusions for post - thoracotomy pain 显示文摘 | Tuncel G Ozalp G Savli S | 2005 | Eur J Cardiothorac Surg2005，28，3： | 1 |
| 11 | Wet deposition of major ions and trace elements in the eastern Mediterranean basin(acid rain) 显示文摘 | Al-Momani I Aygun S Tuncel G | 1998 | Journal of Geophysical Research1998，103，： | 1 |
| 12 | Epidural ropivacaine or sufentanil-ropivaeaine infusions for post-thoracotomy pain 显示文摘 | Tuncel G Ozalp G Savil S | 2005 | Eur J Cardiothorac Surg2005，28，3： | 1 |
| 13 | Trace metal and major ion composition of wet and dry deposition in Ankara, Turkey 显示文摘 | Kaya G Tuncel G | 1997 | Atmospheric Environment1997，31，23： | 1 |
| 14 | Risk assessment and managementfor supply chain networks : A case study 显示文摘 | TUNCEL G ALPAN G | 2010 | Computers inIndustry2010，61，3： | 1 |
| 15 | Average mass concentrations of TSP, PM10 and PMz5 in Erzurum urban atmosphere, Turkey显示文摘 | BAYRAKTAR H TURALIOGLU F S TUNCEL G | 2010 | Stochastic Environmental Research and Risk Asses sment2010，24，1： | 1 |
| 16 | Wet deposition of majorions and trace elements in the eastern Mediterranean basin 显示文摘 | Al-Momani I F Aygun S Tuncel G | 1998 | Journal of Geophysical Research : Atmospheres1998，103，7： | 1 |
| 17 | Epidural ropivacaine or sufentanil-ropivacaine infusions for post-thoracotomy pain显示文摘 | Tuncel G Ozalp G Savli S | 2005 | Eur J Cardiothorac Surg2005，28，3： | 1 |
| 18 | Myoepithelial carcinoma in the nasopharynx:an unusual location显示文摘 | Tuncel U Ergul G Ozlugedik S | 2004 | Yonsel Med J2004，45，1： | 1 |
| 19 | Multivariate statistics to investi- gate metal contamination in surface soil 显示文摘 | Yay O D Alagha O Tuncel G | 2008 | Journal of Environ- mental Management2008，86，： | 1 |
| 20 | Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats显示文摘 | Kavalali G Tuncel H Goksel S | 2003 | Ethnopharmacol2003，84，23： | 1 |
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