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| 1 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 2 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 3 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 4 | Nitrification of ammonical fertilizers in some California soils显示文摘 | Broadbent F E Tyler K B Hill G N | 1957 | Hilgardia1957，27，： | 1 |
| 5 | Preliminary Test on An Energy Absorbing Element for Braced Structures under Earthquake Loading显示文摘 | Tyler R G | 1983 | Bulletin of the New Zealand National Society for Earthquake Engineering1983，16，3： | 1 |
| 6 | Management strategies to decrease calf death losses in beef herds显示文摘 | LARSON R L TYLER J W SCHULTZ L G | 2004 | J Am Vet Med Assoc2004，224，1： | 1 |
| 7 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 8 | Nanodiamond bioconjugate probes and their collection by electrophoresis 显示文摘 | Hens S C Cunningham G Tyler T | 2008 | Diamond Relat Mater2008，17，11： | 1 |
| 9 | Tapered Steel Energy Dissipators for Earthquake Resistant Structures 显示文摘 | Tyler R G | 1978 | Bulletin of The New Zealand National Society for Earthquake Engineering1978，11，4： | 1 |
| 10 | Tapered steel energy dissipators for earthquake resistant structure显示文摘 | Tyler R G | 1978 | Bulletin of The New Zealand National Society for Earthquake Engineering1978，11，4： | 1 |
| 11 | Heavy-metal ecology of terrestrial plants, microorganisms and invertebrates 显示文摘 | Tyler G Pahlsson M B Bengtsson G | 1989 | Water Air and Soil Pollution1989，47，34： | 1 |
| 12 | Vadose-zone Tech- niques for Estimating Groundwater Recharge in Arid and Semiarid Regions显示文摘 | Alison G B Gee G B Tyler S W | 1994 | Soil Science Society of A- merica1994，58，1： | 1 |
| 13 | Wet-milling,composition and functional properties of starch and protein isolated from buckwheat groats 显示文摘 | Zheng G H Sosulski F W Tyler R T | 1998 | Food Research International1998，30，7： | 1 |
| 14 | Reovirus-induced sigma1s-dependent G2/M phase cell cycle arrest is associated with inhibition of p34cdc2显示文摘 | Poggioli G J Dermody TS Tyler KL | 2001 | J Virol2001，75，： | 1 |
| 15 | Heavy metal, ecology of terrestrial plants, microorganisms and invertebrates: A review 显示文摘 | Tyler G Balsberg P A M Bengtsson G | 1989 | Water Air and Soil Pollution1989，47，： | 1 |
| 16 | Hematologic and semen quality changes in bulls with experimental eperythrozoon infection显示文摘 | WELLES E G TYLER J W WOLFE D F | 1995 | Teriogenology1995，43，： | 1 |
| 17 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R Bfighty G | 1998 | Environ Sci Technol1998，32，17： | 1 |
| 18 | Heavy metal ecology of terrestrial plants microorganismsand invertebrates显示文摘 | Tyler G | 1989 | Water Air and Soil Pollution1989，47，： | 1 |
| 19 | Rare earth dement in soil and plant systems - a review显示文摘 | Tyler G | 2004 | Plant and Soil2004，267，： | 1 |
| 20 | Axial flow compressor noise studies显示文摘 | Tyler J M Sofrin T G | | 0，，： | 1 |
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