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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006，4，1： | 17 |
| 2 | Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep显示文摘Osteopontin(OPN; also known as Secreted Phosphoprotein 1, SPP1) is a secreted extra-cellular matrix(ECM) protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ECM adhesion and communication. It is generally accepted that OPN interacts with apically expressed integrin receptors on the uterine luminal epithelium(LE)and conceptus trophectoderm to attach the conceptus to the uterus for implantation. Research conducted with pigs and sheep has significantly advanced understanding of the role(s) of OPN during implantation through exploitation of the prolonged peri-implantation period of pregnancy when elongating conceptuses are free within the uterine lumen requiring extensive paracrine signaling between conceptus and endometrium. This is followed by a protracted and incremental attachment cascade of trophectoderm to uterine LE during implantation, and development of a true epitheliochorial or synepitheliochorial placenta exhibited by pigs and sheep, respectively. In pigs, implanting conceptuses secrete estrogens which induce the synthesis and secretion of OPN in adjacent uterine LE. OPN then binds to αvβ6 integrin receptors on trophectoderm, and the αvβ3 integrin receptors on uterine LE to bridge conceptus attachment to uterine LE for implantation. In sheep, implanting conceptuses secrete interferon tau that prolongs the lifespan of CL. Progesterone released by CL then induces OPN synthesis and secretion from the endometrial GE into the uterine lumen where OPN binds integrins expressed on trophectoderm(αvβ3) and uterine LE(identity of specific integrins unknown) to adhere the conceptus to the uterus for implantation. OPN binding to the αvβ3 integrin receptor on ovine trophectoderm cells induces in vitro focal adhesion assembly, a prerequisite for adhesion and migration of trophectoderm, through activation of: 1) P70S6 K via crosstalk between FRAP1/MTOR and MAPK pathways; 2) MTOR,PI3 K, MAPK3/MAPK1(Erk1/2) and MAPK14(p38) signaling to stimulate trohectoderm cell migration; and 3) focal adhesion assembly and myosin II motor activity to induce migration of trophectoderm cells. Further large in vivo focal adhesions assemble at the uterine-placental interface of both pigs and sheep and identify the involvement of sizable mechanical forces at this interface during discrete periods of trophoblast migration, attachment and placentation in both species. | Greg A Johnson Robert C Burghardt Fuller W Bazer | 2015 | Journal of Animal Science and Biotechnology2015，6，2： | 4 |
| 3 | Uterine biology in pigs and sheep显示文摘There is a dialogue between the developing conceptus (embryo-fetus and associated placental membranes) and maternal uterus which must be established during the peri-implantation period for pregnancy recognition signaling, implantation, regulation of gene expression by uterine epithelial and stromal cells, placentation and exchange of nutrients and gases. The uterus provide a microenvironment in which molecules secreted by uterine epithelia or transported into the uterine lumen represent histotroph required for growth and development of the conceptus and receptivity of the uterus to implantation. Pregnancy recognition signaling mechanisms sustain the functional lifespan of the corpora lutea (CL) which produce progesterone, the hormone of pregnancy essential for uterine functions that support implantation and placentation required for a successful outcome of pregnancy. It is within the peri-implantation period that most embryonic deaths occur due to deficiencies attributed to uterine functions or failure of the conceptus to develop appropriately, signal pregnancy recognition and/or undergo implantation and placentation. With proper placentation, the fetal fluids and fetal membranes each have unique functions to ensure hematotrophic and histotrophic nutrition in support of growth and development of the fetus. The endocrine status of the pregnant female and her nutritional status are critical for successful establishment and maintenance of pregnancy. This review addresses the complexity of key mechanisms that are characteristic of successful reproduction in sheep and pigs and gaps in knowledge that must be the subject of research in order to enhance fertility and reproductive health of livestock species. | Fuller W Bazer Gwonhwa Song Jinyoung Kim Kathrin A Dunlap Michael Carey Satterfield Gregory A Johnson Robert C Burghardt Guoyao Wu | 2012 | Journal of Animal Science and Biotechnology2012，3，3： | 3 |
| 4 | Characteristics of wave propagation and energy distributions in cylindrical elastic shells filled with fluid显示文摘 | Fuller C R Fahy F J | 1982 | JSV1982，81，4： | 2 |
| 5 | A fuzzy approach to R&D project portfolio selection显示文摘 | Carlsson C Fuller R | 2007 | International Journal of Appraximate Reasoning2007，44，2： | 1 |
| 6 | Content-based image and video retrieval显示文摘 | Bach J Fuller C Gupta A | 2005 | Signal Processing2005，85，2： | 1 |
| 7 | On possibilistic mean value and variance of fuzzy numbers 显示文摘 | Carlsson C Fuller R | 2001 | Fuzzy Sets Syst2001，122，： | 1 |
| 8 | Active control of coupled waved propagation in fluid-filled elastic shell 显示文摘 | Brevar B J Fuller C R | 1993 | Journal of Sound and Vibration :1993，94，3： | 1 |
| 9 | Characteristics of wave propagation and energy distributions in cylindrical elastic shells filled with fluid显示文摘 | Fuller C R Fahy F J | 1982 | Journal of Sound and Vibration1982，81，4： | 1 |
| 10 | Integrated CFD modeling of gas turbine combustion 显示文摘 | Fuller E J smith C E | 1993 | AIAA-93-21961993，，： | 1 |
| 11 | An investigation of premor- bid cognitive functioning in schizophrenia using the Iowa test of basic skills and the Iowa test of educational development 显示文摘 | Fuller R L Nopoulos P C Amdt S | 2001 | Schizophr Res2001，49，12： | 1 |
| 12 | Video - assisted thoracic surgery lobectomy : experience with 1,100 cases 显示文摘 | MCKENNA R J Jr HOUCK W FULLER C B | 2006 | Ann Thorac Surg2006，81，2： | 1 |
| 13 | An analytical and experimental investigation of active structural acoustic control of noise transmission through double panel systems 显示文摘 | Carneal J P Fuller C R | 2004 | Journal of Sound and Vibration2004，272，： | 1 |
| 14 | Task Difficulty and Risk in the Determination of Driver Behaviour显示文摘 | Fuller R Mchugh C Pender S | 2008 | Re- vue Europ6enne De Psychologie Appliqu~e/European Review of Applied Psychology2008，58，1： | 1 |
| 15 | Development of an Observational Measure of Healthcare Worker Hand-hygiene Behaviour:the Hand-hygiene Observation Tool (HHOT)显示文摘 | McAteer J Stone S Fuller C | 2008 | J Hosp Infect2008，68，3： | 1 |
| 16 | Laser-induced fluorescence and Langmuir probe determination of Cl and Cl^+ absolute densities in transformer-coupled chlorine plasmas显示文摘 | MALYSHEV M V FULLER N C M K BOGART H A | 1999 | Appl Phys Lett1999，74，12： | 1 |
| 17 | A methanol sensor for portable direct methanol fuel cells显示文摘 | Barton S A C Murach B L Fuller T F | 1998 | Journal of the electrochemical society1998，145，11： | 1 |
| 18 | Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis显示文摘 | Marino S Pawar S Fuller C L | 2004 | J Immunol2004，173，1： | 1 |
| 19 | Relative bioavailability of β-carotene from supplement sources显示文摘 | FULLER C J BUTTERFOSS D N FAILLA M L | 2001 | Nutr Res2001，21，： | 1 |
| 20 | The reproductive biology of Sclerpagesformosas (Maller Schlegel) ( Osteoglossomorpaha, Osteoglossidae) in Malaya, and morphology of its pituitary gland 显示文摘 | SCOTT D B C FULLER J D | 1976 | Journal of Fish Biology1976，8，1： | 1 |
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