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| 1 | Vaccinations in immunosuppressive-dependent pediatric inflammatory bowel disease显示文摘AIM To determine the vaccination rates in pediatric immunosuppression-dependent inflammatory bowel disease(IBD) and review the safety and efficacy of vaccinations in this population.METHODS The electronic medical records from October 2009 to December 2015 of patients diagnosed with IBD at 10 years of age or younger and prescribed antitumor necrosis factor alpha(anti-TNF-α) therapy were reviewed for clinical history, medication history, vaccination history, and hepatitis B and varicella titers. Literature discussing vaccination response in IBD patients were identified through search of the MEDLINE database and reviewed using the key words 'inflammatory bowel disease', 'immunization', 'vaccination', 'pneumococcal', 'varicella', and 'hepatitis B'. Non-human and non-English language studies were excluded. Search results were reviewed by authors toselect articles that addressed safety and efficacy of immunizations in inflammatory bowel disease.RESULTS A total of 51 patients diagnosed with IBD prior to the age of 10 and receiving anti-TNF-α therapy were identified. Thirty-three percent of patients(17/51) had incomplete or no documentation of vaccinations. Sixteen case reports, cohort studies, cross-sectional studies, and randomized trials were determined through review of the literature to describe the safety and efficacy of hepatitis B, pneumococcal, and varicella immunizations in adult and pediatric patients with IBD. These studies showed that patients safely tolerated the vaccines without significant adverse effects. Importantly, IBD patients receiving immunosuppressive medications, particularly anti-TNF-α treatment, have decreased vaccine response compared to controls. However, the majority of patients are still able to achieve protective levels of specific antibodies. CONCLUSION Immunizations have been shown to be well-tolerated and protective immunity can be achieved in patients with IBD requiring immunosuppressive therapy. | Huyen-Tran Nguyen Phillip Minar Kimberly Jackson Patricia C Fulkerson | 2017 | World Journal of Gastroenterology2017，23，42： | 2 |
| 2 | Maximum flow through a network显示文摘 | FORD L R FULKERSON D R | 1956 | Canadian Journal of Math1956，，8： | 1 |
| 3 | Flows in infinite graphs 显示文摘 | Folkman J Fulkerson D R | 1970 | J Combin Theory1970，，8： | 1 |
| 4 | Biomechanics of locked plates and screws 显示文摘 | Egol KA Kubiak EN Fulkerson E el al | 2004 | J Orthop Trauma2004，18，8： | 1 |
| 5 | Fixation of periprosthetic femoral shaft fractures associated with cemented femo- ral stems: a biomechanical comparison of locked plating and conven- tional cable plates显示文摘 | FULKERSON E KOVAL K PRESTON C F | 2006 | J Orthop Trauma2006，20，2： | 1 |
| 6 | Solution of a Large-scale Travelling Salesman Problem显示文摘 | Dantzig G Fulkerson R Johnson S | 1954 | Operations Research1954，2，4： | 1 |
| 7 | Solution of a largescale traveling salesman problem 显示文摘 | Dantzig GB Fulkerson DR Johnson SM | 1954 | Operations Research1954，2，： | 1 |
| 8 | Biomechanics of lockedplates and screws显示文摘 | Egol KA Kubiak EN Fulkerson E | 2004 | J Orthop Trauma2004，8，： | 1 |
| 9 | Biomechanics of Locked Plates and Screws显示文摘 | Egol KA Kubiak EN Fulkerson E | 2004 | Orthop trauma2004，，18： | 1 |
| 10 | Biomechanics of locked plates and Screws 显示文摘 | Egol KA Kubiak EN Fulkerson E | 2004 | J Orthop Trauma2004，18，8： | 1 |
| 11 | Building a better mouse model:experimental models of chronic asthma显示文摘 | Fulkerson P C Rothenberg M E Hogan S P | 2005 | Clin Exp Allergy2005，35，10： | 1 |
| 12 | Flows in infinite graphs显示文摘 | FOLKMAN J FULKERSON D R | 1970 | J Combin Theory1970，8，： | 1 |
| 13 | Minimizing the number of tankers to meet a fixed schedule显示文摘 | Dantzig G B Fulkerson D R | 1954 | Naval Research Logistics Quarterly1954，，1： | 1 |
| 14 | Pathogenesis and treatment of the adult respiratory distress syndrome显示文摘 | William J Fulkerson MD Neilmaclntyre MD | 1996 | Arch Intem Med1996，156，8： | 1 |
| 15 | Emergent medical and surgical management of mediastinal infantile hemangioma with symptomatic spinal cord compression:case report and literature review显示文摘 | Fulkerson DH Agim NG A1-Shamy G | 2010 | Childs Nerv Syst2010，26，12： | 1 |
| 16 | Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling 显示文摘 | Fulkerson P C Fischetti C A Rothenberg M E | 2006 | Am J Pathol2006，169，6： | 1 |
| 17 | The evolution of locked plates显示文摘 | Kubiak EN Fulkerson E Strauss E | 2006 | J Bone Joint Surg Am2006，88，4： | 1 |
| 18 | Priority for allocation of water soluble carbohydrate reserves during regrowth of Lolium perenne 显示文摘 | Donaghy D J Fulkerson W J | 1998 | Grassand Forage Science1998，53，： | 1 |
| 19 | Biomeehanics of locked plates and screws显示文摘 | Egol KA Kubiak EN Fulkerson E | 2004 | J Orthop Trauma2004，18，8： | 1 |
| 20 | Anterome- dial tibial tubercle transfer without bone graft 显示文摘 | Fulkerson JP Becker GJ Meany JA | 1990 | AmSports Med1990，18，6： | 1 |
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