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| 1 | Pathogenesis of occult chronic hepatitis B virus infection显示文摘Occult hepatitis B infection(OBI) is characterized by hepatitis B virus(HBV) DNA in serum in the absence of hepatitis B surface antigen(HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns.Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays;but more frequently it is due to a strong suppression of viral replication and gene expression.OBI is an entity with world-wide diffusion.The failure to detect HBsAg,despite the persistence of the viral DNA,is due in most cases to the strong suppression of viral replication and gene expression that characterizes this'occult'HBV infection;although the mechanisms responsible for suppression of HBV are not well understood.The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection.Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma. | Rocio Aller de la Fuente María L Gutiérrez Javier Garcia-Samaniego Conrado Fernández-Rodriguez Jose Luis Lledó Gregorio Castellano | 2011 | World Journal of Gastroenterology2011，17，12： | 12 |
| 2 | Serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation显示文摘Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the Milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The Milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic models predict the risk of HCC recurrence after LT more accurately than Milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of Milan criteria to identify patients at high risk of tumoral recurrence after LT. | Maria J Citores Jose L Lucena Sara de la Fuente Valentin Cuervas-Mons | 2019 | World Journal of Hepatology2019，11，1： | 12 |
| 3 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 4 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 5 | Study of gastrointestinal transit times with capsule endoscopy 显示文摘 | Velayos Jimenez B Fernandez Salazar L Aller de la Fuente R | 2005 | Gastroenterol Hepatol2005，28，6： | 1 |
| 6 | Volatile compounds,quality parameters and consumer acceptance of ‘Pink Lady' apples stored in different conditions显示文摘 | López M L Villatoro C Fuentes T | 2007 | Postharvest Biology and Technology2007，，43： | 1 |
| 7 | Design, Generation and TCA of New Type of Asymmetric Face-Gear Drive with Modified Geometry显示文摘 | Litvin F L Fuentes A Howkins M | 2001 | Comput Methods Appl Mech Engrg2001，190，： | 1 |
| 8 | Design, Generation, and Stress Analysis of Two Versions of Geometry of Face-Gear Drives显示文摘 | LITVIN F L FUENTES A ZANZI C | 2002 | Mechanism and Machine Theory2002，37，10： | 1 |
| 9 | Effect of moderate diet-induced weight loss and weight regain on cardio- vascular structure and function显示文摘 | de las Fuentes L Waggoner AD Mohammed BS | 2009 | J Am Coil Cardiol2009，54，25： | 1 |
| 10 | Antioxidant and Antiplatelet Activities in Extracts from Green and Fully Ripe Tomato Fruits(Solanum lycopersicum)and Pomace from Industrial Tomato Pro cessing显示文摘 | Fuentes E Carle R Astudillo L | 2013 | Evid Based Complement Alternat Med2013，，86： | 1 |
| 11 | Aroma volatile compounds of Fuji apples in relation to harvest date and cold storage technology: A comparison of two seasons显示文摘 | ECHEVERRIA G FUENTES T GRAELL J LARA I LOPEZ M L | 2004 | Postharvest Biology and Technology2004，32，： | 1 |
| 12 | Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development 显示文摘 | Colnot C de la Fuente L Huang S | 2005 | Development2005，132，5： | 1 |
| 13 | Design,manufacture,stress analysis,and experimental tests of low-noise high endurance spiral bevel gears显示文摘 | Litvin F L Fuentes A Hayasaka K | 2006 | Mechanism and Machine Theory2006，41，1： | 1 |
| 14 | Design,manufacture,stress analysis,and experimental tests of low-noise high endurance spiral bevel gears显示文摘 | Litivin Faydor L Alfonso Fuentes Kenichi Hayasaka | 2006 | Mechanism and Machine Theory2006，41，： | 1 |
| 15 | N-terminal pro B-type natriuretic peptide levels:correlation with echocar- diographica|ly determined left vcntricular diastolic function in an ambulatory cohort 显示文摘 | Dong SJ de las Fuentes L Brown AL | 2006 | J Am Soc Echocardiogr2006，19，： | 1 |
| 16 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 17 | Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells 显示文摘 | Zaba L C Fuentes D J Eungdamrong N J | 2009 | J Invest Dermatol2009，129，1： | 1 |
| 18 | People tracking in surveillance applications显示文摘 | FUENTES L M VELASTIN S A | 2006 | Image and Vision Computing2006，24，11： | 1 |
| 19 | Effect of dietary supplementation with red wine extract or vitamin E, in combination with linseed and fish oil,on lamb meat quality显示文摘 | Muino I Apeleo E Fuente J D L | 2014 | Meat Science2014，98，2： | 1 |
| 20 | Relation of left ventricular lead placement in cardiac resynchronization therapy to left ventricular reverse remodeling and to diastolic dyssynchrony显示文摘 | Rovner A de Las Fuentes L Faddis MN | 2007 | Am J Cardiol2007，99，2： | 1 |
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