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| 1 | ALK易位性甲状腺乳头状癌的临床病理分析显示文摘目前,有报道指出甲状腺乳头状癌( PTC)中存在致病基因ALK的易位。作者在免疫组化的基础上,对免疫组化阳性病例通过荧光原位杂交( FISH)进一步识别ALK重排型PTC。本文对259例侵袭性较强的甲状腺癌进行免疫组化和FISH分析,8例免疫组化阳性的病例中,通过FISH证实有6例存在ALK易位,特异性为75%;其余251例免疫组化阴性的病例, FISH检查同样阴性,敏感性为100%。在498例未经筛选过的PTCs中,11例(2.2%)发现ALK易位,23例弥漫性硬化型PTCs中3例(13%)发现ALK易位;36例伴远处转移的PTCs、28例差分化癌(岛状癌)、20例间变性癌中未发现ALK易位;14例ALK易位的患者全部为女性( P=0.0425),且发生在较年轻的患者(平均年龄38岁,而所有患者的平均48岁,P=0.0289)。 ALK易位出现在所有肿瘤细胞的早期克隆性事件中,与 BRAFV600E 突变相互排斥。 ALK易位与侵袭性的临床病理特征无关(包括瘤体大小、分期、转移、血管侵犯、腺外播散、复发的风险及放射性碘抵抗性)。作者通过免疫组化和FISH发现2.2%的PTCs中存在ALK的易位,ALK易位在年轻女性和弥漫硬化型PTC患者中更加常见,但并不意味着侵袭性的临床过程。 | Chou A Fraser S Toon C W 魏建国 许春伟 | 2015 | 临床与实验病理学杂志2015,31,5: | 11 |
| 2 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016,7,1: | 5 |
| 3 | Off-pump coronary artery bypass grafting versus optimal medical therapy alone:effectiveness of incomplete revascularization in high risk patients显示文摘有 multivessel 的 BackgroundGeriatric 病人冠的动脉疾病(CAD ) 是一个挑战性的组对待;这些盒子关于在这些病人上并且经常承担主要外科的实际利益在心队以内得到讨论导致放纵外科的选择。经皮的过程代表一种重要选择,但是冠的解剖可能是相反的。离开泵冠的动脉绕过(OPCAB ) 提供好质量没有暴露病人到的左前面的下降上的接枝(男孩) 心肺绕过,并且可能是在有多重 comorbidities 的病人的理想的选择,不是对合格经皮或在泵上过程。这研究的目的是没有经皮的选择在高风险的病人在中间的后续期间比较幸存,也与 OPCAB 对待或在回顾地从 2008 年 6 月评估到 2013 年 6 月的医药 therapy.MethodsWe 排出,有 multivessel CAD 的 83 个高风险的病人被包括:42 在男孩上用左内部乳房的动脉(LIMA ) 与不完全的离开泵 revascularization 被对待;41 在最佳的医药治疗(OMT ) 被解除,拒绝了外科。后续在 2015 年 3 月结束了,与一电话的会见。主要端点是从所有原因死亡的幸存;第二等的端点从非致命的主要不利心脏的事件(权标) 是从心脏相关的死亡和自由的幸存 .ResultsDuring 列在后面在上面,在 OPCAB 组的 11 死亡和在 OMT 组的 27 死亡发生了。死亡分别地由于在 6 和 15 个病人的心脏的因素。权标在 OMT 组在 OPCAB 组并且在 4 个病人在 6 个病人被观察。关于从所有原因死亡的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 <0.001 ) ,并且 OMT 组带倾向 3.862 的调整分数的危险比率(P <0.001 ) 。关于从心脏相关的事件的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 = 0.002 ) ,并且 OMT 组带倾向 3.663 的调整分数的危险比率(P = 0.010 ) 。有关从权标的自由没有统计上重要的差别(木头等级 = 0.273 ).ConclusionsFor 有 multivessel CAD 的高风险的病人,不是对在泵上合格完全的 revascularization 外科或经皮的过程,有 OPCAB LIMA-on-LAD 提议的不完全的 revascularization 在幸存受益什么时候与 OMT 相比独自一个。 | Filippo Prestipino Cristiano Spadaccio Antonio Nenna Fraser WH Sutherland Gwyn W Beattie Mario Lusini Francesco Nappi Massimo Chello | 2016 | Journal of Geriatric Cardiology2016,13,1: | 4 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017,25,5: | 2 |
| 5 | Endocrine regulation of menstruation 显示文摘 | Jabbour H N Kelly R W Fraser H M | 2006 | Endocr Rew2006,27,1: | 1 |
| 6 | Hyperparathyroidism显示文摘 | Fraser W D | 2009 | Lancet2009,374,11: | 1 |
| 7 | Solving complex conflicts显示文摘 | FRASER N M HIPEL K W | 1979 | IEEE Transactions on Systems Man and Cybernetics1979,9,12: | 1 |
| 8 | Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival 显示文摘 | Ye Q Fraser CC Gao W | 2002 | J Exp Med2002,195,6: | 1 |
| 9 | Bacterial genome adaptation to niches: Divergence of the potential virulence genes in three Burkholderia species of different survival strategies 显示文摘 | Fraser C M Casjens S Huang W M | 2005 | BMC Genomics2005,6,1: | 1 |
| 10 | Lobster-ISS: An imaging X-ray all-sky monitor for the international space station显示文摘 | FRASER G W BRUNTON A N BANNISTER N P | 2002 | SPIE2002,4497,: | 1 |
| 11 | The electron detection efficiency of microchannel plates显示文摘 | Fraser G W | 1983 | Nuclear Instruments and Methods1983,206,: | 1 |
| 12 | Severe hypocalcaemia after being given intravenous bisphosphonate 显示文摘 | Peter R Mishra V Fraser W D | 2004 | BMJ2004,328,7435: | 1 |
| 13 | Influence of alternative and conventional agricultural managerment on soil microbial processes and nitrogen availability显示文摘 | Doran J W Fraser D F Culik M N | 1987 | American Journal of Al- ternative Agriculture1987,2,: | 1 |
| 14 | The soft X-ray quantum detection efficiency of microchannel plates显示文摘 | Fraser G W | 1982 | Nuclear Instruments and Methods1982,195,: | 1 |
| 15 | Geochemistry of crude oils from eastern Indonesia显示文摘 | Peters K E Fraser T H Amris W | 1999 | American Association of Petroleum Geologists Bulletin1999,83,12: | 1 |
| 16 | Nicotine in hair of bar and restaurant workers显示文摘 | Al-delaimy W Fraser T Woodward A | 2001 | New Zealand Medical Journal2001,114,: | 1 |
| 17 | Reduced PP-rings显示文摘 | Fraser J A Nicholson W K | 1989 | Math Japonica1989,34,5: | 1 |
| 18 | Coping with cold:an integrative,multitissue analysis of the transcriptome of a poikilothermic vertebrate显示文摘 | Gracey A Y Fraser E J Li W Z | 2004 | Proceedings of the National Academy of Science of the United States of America2004,101,16: | 1 |
| 19 | Is there a potential therapeutic value of copper & zinc for osteopo- rosis显示文摘 | Lowe N M Fraser W D Jackson M J | 2002 | Proc Nutr Soc2002,61,: | 1 |
| 20 | Mesotrione:a new selective herbicide for use in maize显示文摘 | Mitchell G Bartlett D W Fraser T E M | | 0,,: | 1 |