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| 1 | Shock solution for quasilinear singularly perturbed Robin problem显示文摘The shock solution for the quasilinear singularly perturbed Robin problem is considered. Under suitable conditions and using the theory of differential inequalities the existence and asymptotic behavior of the shock solution for the original boundary value problems are studied. | MO Jiaqi and WANG Hui(1. Anhui Normal University, Wuhu 241000, China 2. National Natural Science Foundation of China, Beijing 100085, China) | 2002 | Progress in Natural Science:Materials International2002，12，12： | 70 |
| 2 | Preface显示文摘Materials science and technology is the basis and driving force in the progress of human society,where a great number of research frontiers represented by nanomaterials。 | boyun huang Academician of Chinese Academy of Engineering,Vice-president of China Association for Science and Technology,Vice-chairmen of China Postdoctoral Science Foundation | 2009 | 中国有色金属学会会刊:英文版2009，19，S3： | 56 |
| 3 | INITIAL VALUE PROBLEMS FOR SECOND ORDER IMPULSIVE INTEGRO-DIFFERENTIAL EQUATIONS IN BANACH SPACES显示文摘INITIALVALUEPROBLEMSFORSECONDORDERIMPULSIVEINTEGRO┐DIFFERENTIALEQUATIONSINBANACHSPACES**GUODAJUN*AbstractManuscriptreceivedJu... | GUO DAJUN *Department of Mathematics,Shandong Universty,Jinan 250100,Shandong,China. **Project supported by the National Natural Science Foundation of China and the Doctoral Program Foundation of the State Education Commission of China. | 1997 | Chinese Annals of Mathematics,Series B1997，18，4： | 28 |
| 4 | Experimental and clinic-opathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma显示文摘AIM To observe the growth suppression effect of exogenous introduction of early growth response gene-1 (Egr-1 gene) on esophageal carcinoma tissue as well as on esophageal carcinoma cell line Eca109 and to explore the potential application of Egr-1 gene in gene therapy of tumor.METHODS Eukaryotic expression vector of PCMV-Egr-1 plasmid was introduced into Eca109 cell line which expressed no Egr-1 protein originally with lipofectamine transfection method. The introduction and expression of PCMV-Egr-1 plasmid into Eca109 cell line was confirmed by G418 selection culture, PCR amplification of neogene contained in the vector, Western blot analysis and immunocytochemical analysis. The cell growth curve,soft agar colony formation rate and tumorigenicity in SClD mice were examined to demonstrate the growth suppression effect of exogenous Egr-1 gene on Eca109 cell line. The Egr-1 mRNA and Egr-1 protein were also detected in 50 surgical specimens of esophageal carcinoma by in situ hybridization and immunohistochemistry.RESULTS Exogenous Egr-1 gene was introduced successfully into Eca109 cell line and expressed Egr-1 protein stably. The transfected Eca109 cell line grew more slowly than control Eca109 as shown by cell growth curves, the soft agar colony formation rate (4.0% vs 6.9%, P<0.01) and the average growth rate of tumor in SCID mice (35.5 ± 7.6 vs 65.8 ± 7.6, P<0.05). The expression level of Egr-1 mRNA and protein significantly increased in dysplastic epithelia adjacent to cancer rather than in cancer tissues (65.8% vs 20.0% by ISH and 57.9% vs 14.0% by IHC, P<0.01).CONCLUSION Exogenous Egr-1 gene shows the strong effect of growth inhibition in Eca109 cell line. Egr-1 in the cancer tissue shows down-regulated expression that supports the inhibited function of Egr-1 in cancer growth and suggests Egr-1 may have an important role in gene therapy of esophageal carcinoma. | Ming-Yao Wu Mao-Huai Chen Ying-Rui Liang Guo-Zhao Meng Huan-Xing Yang Chu-Xiang Zhuang Department of Pathology,Shantou University Medical College,Shantou 515031,Guangdong Province,China Supported by the National Natural Science Foundation of China,No.39670298. | 2001 | World Journal of Gastroenterology2001，7，4： | 20 |
| 5 | Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87显示文摘AIM To clone the cDNA fragment of human TRAIL (TNFrelated apoptosis inducing ligand) into a tetracyclineregulated gene expression system, the RevTet-On system, transduce expression vectors into a gastric carcinoma cell line-NCl-N87 and examine the effects of controlled expression of TRAIL in vitro on the gastric carcinoma cells.METHODS The full-length cDNA of TRAIL was inserted into a vector under the control of the tetracyclineresponsive element (TRE) to obtain the plasmid pRevTRETRAIL, which was transfected into a packaging cell line PT67. In addition, vector pRev-Tet- On and pRevTRE were also transfected into PT67 separately. After hygromycin and G418 selection, the viral titer was determined. The medium containing retroviral vectors was collected and used to transduce a gastric carcinoma cell line NCI-N87.The resulting cell line NCI-N87-Tet-On-TRE-TRAIL and a control cell line, NCI-N87-Tet-On-TRE, were established.TRAIL expression in the cell line was induced by incubating cells with doxycycline (Dox), which is a tetracycline analogue. The killing effect on gastric carcinoma cells was analyzed after induction.RESULTS The recombinant plasmid pRev-TRE-TRAIL was constructed. After hygromycin or G418 selection, the producer cell lines PT67-TRE, PT67-TRE-TRAIL and PT67TetOn were obtained, with titers of about 108CFU@ L-1 By transducing NCI-N87 cells with retroviral vectors from these cell lines, stable cell lines NCI-N87-Tet-On-TRETRAIL (NN3T) and control cell line NCI-N87-Tet-On-TRE (NN2T) were established. The growth curves of the selected cell lines were the same with the wild type NCIN87. When Dox was added, cell death was obvious in the test groups (29% -77%), whereas no difference was observed in control and wild type cell lines. With the addition of a medium from the test group, human leukemia cell line Jurkat was activated till death (83%), indicating the secretion of active TRAIL proteins from the test cells to the medium.CONCLUSION With the use of the RevTet-On system, a regulated expression system for TRAIL was constructed.Using this system, the selected killing effect of TRAIL on gastric carcinoma cell line NCI-N87 could be observed. | Xiao-Chao Wei Xin-Juan Wang Kai-Chen Lei Zhang Yu Liang Xin-Li Lin Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing 100083,ChinaProtein Studies,Oklahoma Medical Research Foundation,Oklahoma City,OK 73104,USA | 2001 | World Journal of Gastroenterology2001，7，4： | 11 |
| 6 | General expressions of peaked traveling wave solutions of CH-γ and CH equations显示文摘 | ZHANG WenlingDepartment of Mathematics and Physics, National Natural Science Foundation of China, Beijing 100085, China | 2004 | Science China Mathematics2004，47，6： | 10 |
| 7 | Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell lines显示文摘This study aimed to investigate the effects of arsenic trioxide(As2O3) on the mitochondrial DNA(mtDNA) of acute promyelocytic leukemia(APL) cells.The NB4 cell line was treated with 2.0 μmol/L As2O3 in vitro,and the primary APL cells were treated with 2.0 μmol/L As2O3 in vitro and 0.16 mg kg-1 d-1 As2O3 in vivo.The mitochondrial DNA of all the cells above was amplified by PCR,directly sequenced and analyzed by Sequence Navigatore and Factura software.The apoptosis rates were assayed by flow cytometry.Mitochondrial DNA mutation in the D-loop region was found in NB4 and APL cells before As2O3 use,but the mutation spots were remarkably increased after As2O3 treatment,which was positively correlated to the rates of cellular apoptosis,the correlation coefficient:rNB4-As2O3=0.973818,and rAPL-As2O3=0.934703.The mutation types include transition,transversion,codon insertion or deletion,and the mutation spots in all samples were not constant and regular.It is revealed that As2O3 aggravates mtDNA mutation in the D-loop region of acute promyelocytic leukemia cells both in vitro and in vivo.Mitochondrial DNA might be one of the targets of As2O3 in APL treatment. | MENG Ran1,ZHOU Jin2,SUI Meng3,LI ZhiYong4,FENG GuoSheng1 & YANG BaoFeng2 1 Division of Neurology,the Ninth Clinical Medical College of Beijing University(Shijitan Hospital),Beijing 100038,China 2 The First Hospital of Harbin Medical University,Harbin 150001,China 3 Management Information System,University of International Business and Economics,Beijing 100029,China 4 Department of Radiology,Cambridge University Hospitals NHS Foundation Trust Box 219 Level 5,Addenbrooke’s Hospital Cambridge CB2 0QQ,UK | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 8 | Morphology and mapping analysis of rice(Oryza sativa L.)clustered spikelets(Cl)mutant显示文摘The rice clustered spikelets (Cl) mutant exhib-its a phenotype that most of branch apical have 2-3 spikelets clustered together. SEM (scanning electron microscope) ob-servation suggested that the Cl gene controlled branch apical development, and influenced the terminal spikelets elonga-tion. The spikelet number was reduced in mutant, indicating that Cl may also have an effect on spikelet number. To map Cl locus, two F2 mapping populations derived from the crosses between the Cl and ZhongHua11, and Cl and ZheFu802 were constructed, respectively. The Cl locus was roughly mapped between two CAPS markers, CK0214 and SS0324. A further fine mapping analysis showed that the Cl locus was mapped between makers R0674E and Cl2560, with genetic distances of 0.2 and 2.1 cM, respectively. Then we found a PAC contig spanning Cl locus, the region was delim-ited to 196 kb. This result was useful for cloning of the Cl gene. Allelism test demonstrated that Cl was allelic to Cl2, another rice clustered spikelets mutant. | ZHENG Leiying1, ZHU Xudong2, QIAN Qian2, ZHAO Zhong1, ZHANG Jianjun3, HU Xiaohe1, LIN Hongxuan1,4 & LUO Da1 1. National Key Laboratory of Plant Molecular Genetics, Shanghai In-stitute of Plant Physiology and Ecology, Chinese Academy of Sci-ences, Shanghai 200032, China 2. China National Rice Research Institute, Hangzhou 310006, China 3. Crop Institute of Breeding and Cultivation, Shanghai Agricultural Academy, Shanghai 201106, China 4. Shanghai Anxin Research Foundation Laboratory, Shanghai 200032, China | 2003 | Chinese Science Bulletin2003，48，6： | 10 |
| 9 | CONTINUOUS L-DOMAINS显示文摘Two characterization theorems of continuous L-domain are given. Then a problem raisedby J. D. Lawson and M. Mislove is solved. | LIANG JIHUA LIU YINGMING(Institute of Mathematics, Sichuan University, Chengdu 610064, China.)(Project supported by the National Natural Science Foundation of China.) | 1996 | Chinese Annals of Mathematics,Series B1996，17，3： | 8 |
| 10 | Four types of bounded wave solutions of CH-■ equation显示文摘Recently, many authors have studied the following CH-γequation: ut + c0ux + 3uux -α2(wxxt + uuxxx + 2uxuxx) 4-γuxxx = 0,whereα2, c0 andγare paramters. Its bounded wave solutions have been investigated mainly for the caseα2 > 0. For the caseα2 < 0, the existence of three bounded waves (regular solitary waves, compactons, periodic peakons) was pointed out by Dullin et al. But the proof has not been given. In this paper, not only the existence of four types of bounded waves: periodic waves, compacton-like waves, kink-like waves, regular solitary waves, is shown, but also their explicit expressions or implicit expressions are given for the caseα2 < 0. Some planar graphs of the bounded wave solutions and their numerical simulations are given to show the correctness of our results. | Min-ying TANG & Wen-ling ZHANG School of Mathematical Sciences and Center for Nonlinear Science Studies, South China University of Technology, Guangzhou 510640, China ( Department of Mathematics and Physics, National Natural Science Foundation of China, Beijing 100085, China | 2007 | Science China Mathematics2007，50，1： | 8 |
| 11 | 中国太湖1950年以来主要环境的变化和迅速富营养化的开始显示文摘太湖是我国第三大淡水湖,面积2350km2,位于长江三角洲(面积35000km2)的中部,自6000年前太湖形成以来,湖泊经历了几个主要变化。1950年以前,太湖最明显的变化发生在海侵和湖盆大小。海侵是太湖形成的主要原因。太湖形成后,在不同的干燥和湿润时期,湖盆经历了由一系列的小湖或统一湖盆之间的波动。但一般来说,近2000年以来,湖盆的大小在增大。然而1950年以后,为适应人口的增长,许多浅水地带被改造成农田和鱼塘。50年代以来,对湖盆和流域的进一步利用导致湖泊发生了一些变化。在这个阶段太湖的主要变化是:1)对排水流域、湖泊生态和营养状况具有重大影响的堤坝的修筑和湖岸的改造;2)始于1983/1984年湖泊的迅速富营养化。湖泊迅速富营养化的主要原因是由于工业、农业和城市化的迅速增长,导致未经处理的废水排入湖盆。每年这些营养物大量排入,对湖泊的营养状况影响甚重,在低水位时尤其如此。 | William Y.B.Chang(Center for Great Lakes and Aquatic Sciences and School of Natural Resources and Environment,the University of Michigan,Ann Arbor,Michigan 48109,U.S.A.andDivision of International Programs National Science Foundation,Foundation,Arlington, | 1996 | 古生物学报1996，35，2： | 8 |
| 12 | PERIODIC SOLUTIONS OF ASYMPTOTICALLY LINEA RHAMILTONIAN SYSTEMS显示文摘PERIODICSOLUTIONSOFASYMPTOTICALLYLINEARHAMILTONIANSYSTEMSFeiGuihuaQiuQingjiuManuscriptreceivedDecember5,1994.RevisedSepte... | Fei Guihua * Qiu Qingjiu * Manuscript received December 5, 1994.Revised September 7, 1995. *Department of Mathematics, Nanjing University, Nanjing 210008, China. **Project supported by the National Natural Science Foundation of China. | 1997 | Chinese Annals of Mathematics,Series B1997，18，3： | 7 |
| 13 | Paleoenvironmental information recorded by pollen in B-3GC gravity core in Okinawa Trough显示文摘Based on pollen records in B-3GC gravity core, environmental change since 9500 aBP of Okinawa Trough and its adjacent islands was derived. The result showed that the most time during this period was in a warm temperate climate except in middle Holocene (6800-4400 aBP) that was under subtropical climate control. During 9500-8300 aBP and 3100-2000 aBP periods, it appeared colder and drier than the rest time. The original area of pollen sources surrounding Okinawa Trough was covered by evergreen and deciduous broadleaf forest alternatively with mixed broad-leaf-conifer forest distributed in high mountainous areas. Usually, these three kinds of forests existed at the same time with difference in altitude. Pollen from subtropical and tropical plants increased obviously in about 5000-6000 aBP, reflecting a great lifting of vegetation zone and expansion of evergreen broad-leaf forest in the study area. However, there was a slight descending of plant zone and shrinking of evergreen broadleaf forest during | SONG Changqing, SUN Xiangjun & Yoshiki SaitoNational Natural Science Foundation of China, Beijing 100085, China Open Lab of Marine Geology, Tongji University, Shanghai 200039, China Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China Geological Survey of Japan, Higashi 1-1-3, Tsukuba, Ibaraki, 305-8567,Japan | 2001 | Chinese Science Bulletin2001，46，11： | 7 |
| 14 | TWO-DIMENSIONAL SEDIMENT MATHEMATICAL MODEL FORUNSTEADY FLOW IN THE LOWER YELLOW RIVER显示文摘The theoretical frame of a new two-dimensional sediment mathematical model is established on the basis of the resent research achievements about the sediment transport law of the Yellow River. The formulas of sediment carrying capacity of flow and river roughness, which reflect the features of the Yellow River, are applied to it. The finite element scheme is employed to deduce the discretized equations of the model. The pre-estimated-verified substitution is used to solve them. Verifications of the model are carried out with the flood occurring on Jinan reach of the Yellow River during the flood season in 1976. The calculation results with the model are in good agreement with the measured data. | ZHANG Hongwu LI Dongfeng XU Yuxin ZHANG Junhua (1 Project (No. 39890200) Supported by the National Nature Science Foundation Commission and the Ministry of Water Conservancy 2 Yellow River Institute of Hydraulic Research, Zhengzhou 450003, China 3 Ye | 1999 | International Journal of Sediment Research1999，14，2： | 5 |
| 15 | Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes显示文摘Paeoniflorin (PF ) 是从 Paeonia lactiflora 的根提取的主要有效部件之一,它临床上被使用了在未知的内在的 mechanismremain 的繁体中文药,而是细节对待肝炎。现在的学习被设计在 d-galactosamine (GalN ) 和肿瘤坏死因素上调查 PF 的保护的效果的机制 --(TNF-) 用人的 L02 hepatocytes 导致了房间 apoptosis。我们 PF 能稀释的 resultsconfirmed GalN/TNF -- 以一种剂量依赖者方式的导致的 apoptotic 房间死亡。mitochondrialmembrane 潜力和细胞内部的 Ca 2+ 集中的骚乱的混乱被 PF 也恢复。西方的污点分析表明 GalN/TNF- 导致了一个 numberof 签名 endoplasmic 蜂窝胃的激活(嗯) 压力和 mitochondrial 标记,当 PF 预告的处理在他们上有显著 dose-dependentsuppression 时。另外, PF 的 anti-apoptotic 效果被 caspase-3/9activities 的抑制进一步在 L02 房间证实。这些调查结果建议那 PF 能有效地禁止与调整调停人有关的 hepatocyte apoptosis 和内在的 mechanismis 在嗯压力和线粒体依赖者小径。 | Zequn Jiang Funding This work was supported by grants from the National Natural Science Foundation of China (81072777 and 81273638) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).Weiping Chen Xiaojing Yan Lei Bi Sheng Guo Zhen Zhan | 2014 | Acta Biochimica et Biophysica Sinica2014，46，5： | 5 |
| 16 | FINITENESS CONDITIONS FOR GENERALIZED EXPONENTS OF DIGRAPHS显示文摘Necessary and sufficient conditions are given for the finiteness of the generalized exponents expD(k), f(D, k) and F(D, k) for digraphs which are not necessarily primitive. Also the largest finite value of the generalized exponent expD(k) for digraphs of order n is determined and the complete characterizations of the extreme digraphs are given. | SHAO JIAYU (Department of Applied Mathematics, Tonsil University, Shanghai 200092, China.)WU XIAOJUN (Project supported by the National Natural Science FOundation of China and Shanghai Science anda’echnolgy Developing FOundation.) | 1998 | Chinese Annals of Mathematics,Series B1998，19，4： | 5 |
| 17 | 2003年工程与材料科学国家和部门重点实验室评估工作总结显示文摘 | National Natural Science Foundation of China | 2004 | 中国基础科学2004，6，1： | 4 |
| 18 | Weighted L^p-estimates for Stokes flow in R_+~n with applications to the non-stationary Navier-Stokes flow显示文摘We study the time-decay properties of weighted norms of solutions to the Stokes equations and the Navier-Stokes equations in the half-space Rn+ (n 2). Three kinds of the weighted Lp-Lr estimates are established for the Stokes semigroup generated by the Stokes operator in the half-space R+n (n 2). As an application of the weighted estimates of the Stokes semigroup, a class of local and global strong solutions in weighted Lp (R+n) are constructed, following the approach given by Kato. | HE Cheng1 & WANG LiZhen21Division of Mathematics, Department of Mathematical and Physical Sciences, National Natural Science Foundation of China, Beijing 100085, China 2Department of Mathematics and Center for Nonlinear Studies, Northwest University, Xi’an 710069, China | 2011 | Science China Mathematics2011，54，3： | 3 |
| 19 | IMPACT OF DEBRIS FLOW ON RIVER CHANNEL IN THE UPPERREACHES OF THE YANGTZE RIVER显示文摘A debris flow gully is a 'sediment highway'. Debris flow carries huge amount of sediment into river in extreme short time. which reduces discharge capacity of the river and even blocks up the river and also causes river bank erosion. | Peng CUI (1 This research is a part of key project supported by National Natural Scence Foundation (basic) (project No. 49831010). 2 Institute of Mountain hazards and Environment, Dongchuan Debris Flow Study Station. Chinese Academy of Sciences. Chengdu | 1999 | International Journal of Sediment Research1999，14，2： | 3 |
| 20 | Interactions of pyrogallol red with proteins and the determination of proteins by resonance light-scattering | Hu Xiaoli, female, 35 years old, instructor. * Supported by the National Natural Science Foundation of China (NSFC) and the Municipal Science Foundation of Chongqing for Young and Middle Scientists (No: 97-4729). Hu Xiaoli, Feng Ping, Li Yua | 1998 | 西南师范大学学报(自然科学版)1998，23，5： | 3 |
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