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| 1 | Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review显示文摘The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy types.Being them an innovation in the antiepileptics armamentarium,a lot of investigations regarding their pharmacological properties are yet to be performed.Besides,considering their broad anticonvulsant activities,an extension of their therapeutic indications may be worthy of investigation,especially regarding other seizure types as well as other central nervous system disorders.Although different liquid chromatographic(LC)methods coupled with ultraviolet,fluorescence,mass or tandem-mass spectrometry detection have already been developed for the determination of perampanel,retigabine,rufinamide and stiripentol,new and more cost-effective methods are yet required.Therefore,this review summarizes the main analytical aspects regarding the liquid chromatographic methods developed for the analysis of perampanel,retigabine(and its main active metabolite),rufinamide and stiripentol in biological samples and pharmaceutical dosage forms.Furthermore,the physicochemical and stability properties of the target compounds will also be addressed.Thus,this review gathers,for the first time,important background information on LC methods that have been developed and applied for the determination of perampanel,retigabine,rufinamide and stiripentol,which should be considered as a starting point if new(bio)analytical techniques are aimed to be implemented for these drugs. | Sara Meirinho Marcio Rodrigues Ana Fortuna Amílcar Falcao Gilberto Alves | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 2 |
| 2 | Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome 显示文摘 | Fortuna AM Miralda R Calaf N | 2011 | Respir Med2011，105，： | 1 |
| 3 | Liquid chromatographic methods for the quantification of catecholamines and their metabo-lites in several biological samplesA review 显示文摘 | Bicker J Fortuna A Alves G | 2013 | Analytica chim- ica acta2013，768，： | 1 |
| 4 | A roll stabilization system for a monohull ship: modeling identification and adaptive control显示文摘 | Fortuna L Musccato G | 1996 | IEEE Transactions on Control System Technology1996，4，1： | 1 |
| 5 | Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome 显示文摘 | Fortuna AM Miralda R Calaf N | 2011 | Respir Med2011，105，4： | 1 |
| 6 | Transient global brain ischemia in young and aged rats: differences in severity and progression, but not localisation, of lesions evaluated by mag- netic resonance imaging显示文摘 | CANESE R FORTUNA S LORENZINI P | 1998 | MAGMA1998，7，1： | 1 |
| 7 | Human capital, R N-D, trade, and long-run productivity, testing the technological absorption hypothesis {or the portuguese economy, 1960- 2001显示文摘 | TEIXEIRA A A C FORTUNA N | 2010 | Research Policy2010，39，3： | 1 |
| 8 | Does chaos work better than noise显示文摘 | Caponetto R Fortuna L | 2002 | Circuits and Systems Magazine IEEE2002，2，3： | 1 |
| 9 | Chaotic sequence to improve the performance of evolutionary algorithms显示文摘 | CAPONETTO R FORTUNA L FAZZINO S XIBILIA M G | 2003 | IEEE Transactions on Evolutionary Computation2003，7，3： | 1 |
| 10 | Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome显示文摘 | Fortuna AM Miralda Rv Calaf N | 2011 | Respir Med2011，105，4： | 1 |
| 11 | The effects of electrical stimulation exercise on muscles injected with botulinum toxin type-A (botox)显示文摘 | Fortuna R Horisberger M Vaz M A | 2013 | JBiomech2013，46，1： | 1 |
| 12 | Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura:a critical appraisal from a systematic review of the literature显示文摘 | Ruggefi M Fortuna S Rodeghiero F | 2008 | Haematologica2008，93，： | 1 |
| 13 | The effects of compost and crop rotations on carbon turnover and the particulate organic matter fraction 显示文摘 | FORTUNA A HARWOOD R R PAUL E A | 2003 | Soil Science2003，168，： | 1 |
| 14 | Imaging of cerebral venous thrombosis:current techniques,spectrum of findings,and diagnostic pitfalls 显示文摘 | Leach JL Fortuna P B Jones BV | 2006 | Radiographics2006，261，： | 1 |
| 15 | Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostics pitfalls显示文摘 | Leach JL Fortuna RB Jones BV | 2006 | Radiographics2006，26，： | 1 |
| 16 | Cystic Meningiomas显示文摘 | Fortuna A Ferrante L Acqui M | 1988 | Acta Neurochir(Wien)1988，90，： | 1 |
| 17 | Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature 显示文摘 | Ruggeri M Fortuna S Rodeghiero F | 2008 | Haematologica2008，93，1： | 1 |
| 18 | Soft analyzers for a sulfur recovery unit 显示文摘 | Fortuna L Rizzo A Sinatra M | 2003 | Control Engineering Practice2003，11，12： | 1 |
| 19 | A CNN Algorithm for Real Time Analysis of DNA Microarrays显示文摘 | Arena P Fortuna L Occhipinti L | 2002 | IEEE Trans on Circuits and Systems I:Fundamental Theory and Applications2002，49，3： | 1 |
| 20 | Chemical activation in view of MSWI bottom ash recycling in cement-based sys- tems 显示文摘 | Polettini A Pomi R Fortuna E | 2009 | Journal of Hazardous Materials2009，162，： | 1 |
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