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| 1 | High-risk corneal allografts: A therapeutic challenge显示文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in 'low-risk' settings. Furthermore, although corneal graft survival in 'lowrisk' recipients is favourable, the prognosis in 'high-risk' recipients for corneal graft is poor. In 'high-risk' grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of 'high-risk' recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in 'high-risk' recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both 'low-risk' and 'high-risk' hosts. | Tian Yu Vijayalakshmi Rajendran May Griffith John V Forrester Lucia Kuffová | 2016 | World Journal of Transplantation2016，6，1： | 7 |
| 2 | Penetration of 6061-T651 Aluminum Targets with Rigid Long Rods显示文摘 | FORRESTAL M J OKAJIMA K LUK V K | 1988 | Trans ASME J Appl Mech1988，55，： | 1 |
| 3 | Dynamic spherical cavity-expansion in a compressible elastic-plastic solid 显示文摘 | Forrestal M J Luk V K | 1988 | J Appl Mech1988，55，2： | 1 |
| 4 | Dynamic spherical cavity-expansion in a compressible elastic-plastic solid显示文摘 | Forrestal M J Luk V K | 1988 | Journal of Applied Mechanics1988，55，： | 1 |
| 5 | Dynamic Spherical Cavityexpansion in a Compressible Elastic-plastic Solid 显示文摘 | FORRESTAL M J LUK V K | 1988 | Trans ASME J Appl Mech1988，55，： | 1 |
| 6 | Dynamic spherical cavity-expansion in a compressible elastic-plastic solid 显示文摘 | Forrestal M J Luk V K | 1988 | J Appl Mech Trans ASME1988，55，： | 1 |
| 7 | Penetration of 6061-T651 aluminum targets with rigid long rods显示文摘 | Forrestal M J Okajima K Luk V K | 1988 | Journal of Applied Mechanics1988，55，： | 1 |
| 8 | Penetration of reinforced concrete with ogive-nose penetrators显示文摘 | FORRESTAL M J LUK V K WATTS H A | 1988 | Int J Solids Structures1988，24，1： | 1 |
| 9 | Penetration of Strain-hardening Targets with Rigid Spherical-nose Rods 显示文摘 | FORRESTAL M J BRAR N S LUK V K | 1991 | Trans ASME J Appl Meeh1991，58，1： | 1 |
| 10 | Dynamic spherical cavity expansion of strain-hardening materials 显示文摘 | Luk V K Forrestal M J Amos D E | 1991 | J Appl Mech Trans ASME1991，58，： | 1 |
| 11 | Penetration into soil targets显示文摘 | Forrestal M J Luk V K | 1992 | International Journal of Impact Engineering1992，12，3： | 1 |
| 12 | Perforation of aluminum plates with conical-nosed rods显示文摘 | Forrestal M J Rosenberg Z Luk V K | 1987 | J Appl Mech Trans ASME1987，54，： | 1 |
| 13 | Penetration of strain-hardening targets with rigid spherical-nose rods显示文摘 | FORRESTAL M J BARA N S LUK V K | 1991 | J Appl Meeh1991，58，1： | 1 |
| 14 | Penetration into Soil Target 显示文摘 | Forrestal M J Lu k V K | 1992 | Int J lmpactEngrg1992，12，3： | 1 |
| 15 | Evaluation of corneal graft rejection in a mouse model显示文摘 | Plková J Kuffová L Holá V Filipec M Forrester JV | 2002 | Br J Ophthalmol2002，86，1： | 1 |
| 16 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 17 | Penetration of 6061-T6651 alumnium targets with rigid long rods显示文摘 | Forrestal M J Okajima K Luk V K | 1988 | Journal of Applied Mechanics1988，55，4： | 1 |
| 18 | Enhancement of itreous clotly-sis by urokinase:made of action显示文摘 | Forrester J V Edger W Millar W | 1982 | Exp Eye es1982，34，： | 1 |
| 19 | Expectations, Disconfirmation, and CitizenSatisfaction with the US Federal Government:Testing and Expanding the Model 显示文摘 | Forrest V M | 2013 | Journal of Public Administration Research and Theory2013，，2： | 1 |
| 20 | Penetration of 6061 - T6651 aluminium targets with rigid long rods显示文摘 | Forrestal MT Okajima K L uk V K | 1988 | Journal of Applied Mechanics1988，55，4： | 1 |
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