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| 1 | Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective显示文摘Until very recently, treatment for chronic hepatitis C virus(HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011(Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first timesince the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples. | Karina Salvatierra Sabrina Fareleski Alicia Forcada F Xavier López-Labrador | 2013 | World Journal of Virology2013，2，1： | 2 |
| 2 | The Effect of Melatonin on the Secretion of Progesterone in Sheep and on the Development of Ovine Embryos in Vitro显示文摘 | Abecia J A Forcada F Zuniga O | 2002 | Vet Res Commun2002，26，2： | 1 |
| 3 | Knowledge management perceptions in construction and design companies显示文摘 | FORCADA N FUERTES A GANGOLELLS M | 2013 | Automation in Construction2013，，29： | 1 |
| 4 | Early intrathoracic migration of Kirsehner wires used for pereutaneons osteosynthesis of two-part humeral neck fracture : a case report 显示文摘 | Mellado J M Calmet J Garcia Forcada I L | 2004 | EmergRadiol2004，11，1： | 1 |
| 5 | Repeated superovulation using a simplified FSH/e CG treatment for in vivo embryo production in sheep显示文摘 | Forcada F Ait Amer-Meziane M Abecia J A | 2011 | Theriogenology2011，75，4： | 1 |
| 6 | Differences in the midgut proteolytic activity of two Heliothis virescens strains, one susceptible and one resistant to Bacillus thuringiensis toxins显示文摘 | Forcada C Encarna A Garcera M D | 1996 | Archives of Insect Biochemistry and Physiology1996，31，： | 1 |
| 7 | Surfactant-free miniemulsion polymerization as a simple synthetic route to a successful encapsulation of magnetite nanoparticles 显示文摘 | Ramos J Forcada J | 2011 | Langmuir2011，27，11： | 1 |
| 8 | Semicontinuous emulsion copolymerization of methyl methacrylate and n-butyl acrylate ( 1 ) : Effect of mixed emulsifiers in seeded polymerization显示文摘 | UNZUETA E FORCADA J | 1995 | Polymer1995，36，5： | 1 |
| 9 | Repeated superovu-lation using a simplified FSH/eCG treat-ment for in vivo embryo production in sheep显示文摘 | FORCADA F AIT AMER-MEZIANE M ABECIA JA | 2011 | Theriogenology2011，75，4： | 1 |
| 10 | Population structure and marker-trait associations for pomological traits in peach and nectarine cultivars显示文摘 | Carolina Fonti Forcada Nnadozie Oraguzie Ernesto Igartua | 2013 | Tree Genetics & Genomes2013，9，2： | 1 |
| 11 | Ge- netic relationships and population structure of local olive tree ac- cessions from Northeastern Spain revealed by SSR markers 显示文摘 | MARTI A F I FORCADA C F I COMPANY R S I | 2014 | Acta Physiologiae Plantarum2014，37，1： | 1 |
| 12 | Kinetics of long-chain branching in emulsion polymerization显示文摘 | Forcada J Asua J M | 1994 | Macromolecules1994，27，： | 1 |
| 13 | Pharmaceutical control of reproduction in sheep and goats显示文摘 | Abecia J A Forcada F Gonzdlez-Bulnes A | 2011 | Vet Clin North Am Food Anita Practice2011，27，1： | 1 |
| 14 | Surfactant-free miniemulsion polymerization as a simple synthetic route to a successful encapsulation of magnetite nanoparticles 显示文摘 | Ramos J Forcada J | 2011 | Langmuir2011，27，11： | 1 |
| 15 | Preparation of magnetic polymeric composite nanoparticles by seeded emulsion polymerization显示文摘 | Shulai Lu Rongjun Qu Jacqueline Forcada | 2009 | Materials Letters2009，63，： | 1 |
| 16 | Special situtions in epilepsy: women and the elderly 显示文摘 | Forcadas MI Mayor PP Puig JS | 2007 | Neurologist2007，13，61： | 1 |
| 17 | Resection arthroplasty for radial head fractures: Long-term follow-up 显示文摘 | Iftimie P P Calmet Garcia J de Loyola Garcia Forcada I | 2011 | J Shoulder Elbow Surg2011，20，1： | 1 |
| 18 | N-vinylcaprolactam-based microgels: Effect of the concentration and type of cross linker显示文摘 | IMAZ A FORCADA J | 2008 | Journal of Polymer Science Part A Polymer Chemistry2008，46，8： | 1 |
| 19 | Preparation and characterization of magnetic poly- meric composite particles by miniemulsion polymerization显示文摘 | Lu S Forcada J | 2006 | Jour- nal of Polymer Science Part A : Polymer Chemistry2006，44，13： | 1 |
| 20 | Open bicondylar Hoffa fracture associated with extensor mechanism injury显示文摘 | Calmer J Mellado JM Garcia Forcada IL | 2004 | J Orthop Trauma2004，18，： | 1 |
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