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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Price-driven coordination method for solving plant wide MPC problems显示文摘 | Cheng R Forbes J Yip W | 2007 | Journal of Process Control2007，17，5： | 1 |
| 3 | No contagion, onlyinterdependence; measuring stock market comovements 显示文摘 | FORBES K J RIGOBON R | 2002 | The Journal of Finance2002，57，5： | 1 |
| 4 | Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis 显示文摘 | Lu H Forbes R A Verma A | 2002 | J Biol Chem2002，277，23： | 1 |
| 5 | Bone marrow contributes to renal parenchymal turnover and regeneration显示文摘 | Poulsom R Forbes SJ Hodivala-Dilke K | 2001 | J Pathol2001，195，2： | 1 |
| 6 | Hepatic stem cells显示文摘 | FORBE S VIG P POULSOM R | 2002 | J Pathol2002，197，4： | 1 |
| 7 | Photovoltaie solar cells : an overview of state-of-the-art cell development and environmental issues 显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 8 | Halothane depresses mucociliary flow in the trachea 显示文摘 | Forbes A R | 1976 | Anesthesiology1976，45，1： | 1 |
| 9 | A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes显示文摘 | Candido R Forbes JM Thomas MC | 2003 | Circ Res2003，92，4： | 1 |
| 10 | A randomized controlled trial of extracorporeal shock wave therapy for lateral epicondylitis (tennis elbow) 显示文摘 | STAPLES MP FORBES A PTASZNIK R | 2008 | J Rheumatol2008，35，10： | 1 |
| 11 | The Wilson disease gene: spectrum of mutations and their consequences 显示文摘 | Thomas G R Forbes J R Roberts E A | 1995 | Nat Genet1995，9，2： | 1 |
| 12 | Highly oriented and conducting ZnO: Ga layers grown by chemical spray pyrolysis 显示文摘 | Reddy K T R Reddy T B S Forbes I | 2002 | Surf Coat Technol2002，，1： | 1 |
| 13 | Mucociliary flow in the trachea during anesthesia with enflurane Ether,nitrous oxide,and morphine 显示文摘 | Forbes A R Horrigan R W | 1977 | Anesthesiology1977，46，5： | 1 |
| 14 | Modulation of soluble receptor for advanced glycation end products by angiotensin - converting enzyme - 1 inhibition in diabetic nephropathy 显示文摘 | FORBES J M THORPE S R THALLAS - BONKE V | 2005 | J Am Soc Nephro12005，16，8： | 1 |
| 15 | Formation,transformation and transport of black carmn (charcoal) in terrestrial and aquatic ecosystems显示文摘 | FORBES M S RAISON R J SKJEMSTAD J O | | 0，，01： | 1 |
| 16 | K-Ar studies in two deep basement drill holes: A new geological estimate of argon blocking for blobite显示文摘 | Turner D L Forbes R B | 1976 | Eos1976，57，： | 1 |
| 17 | Designing and Building a CHS Bathy metric Data Warehouse显示文摘 | Forbes S R Burke R G Vanna H | 1999 | International Hydrographic Review1999，，2： | 1 |
| 18 | Photovoltaic solar cells: an overview of state-of-the-art cell development and environmental issues显示文摘 | MILES R W HYNES K M FORBES I | 2005 | Progress in Crystal Growth and Characterization of Materials2005，51，13： | 1 |
| 19 | Human lymphocyte stimula-tion with pouchitis flora is greater than with flora from a healthypouch but is suppressed by metronidazole显示文摘 | BELLA J NICHOLLS R J FORBES A | 2004 | Gut2004，53，： | 1 |
| 20 | Highly oriented and conducting ZnO:Ga layers grown by chemical spray pyrolysis 显示文摘 | Reddy K T R Reddy T B S Forbes I | 2002 | Surface and Coatings Technology2002，，1： | 1 |
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