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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Cervical spinal cord injury complicating ankylosing spondylitis 显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 3 | Effects of team inputsand intrateam processes on perceptions of team viabilityand member satisfaction in nascent ventures显示文摘 | FOO M D SIN H P YIONG L P | 2006 | StrategicManagement Journal2006，27，4： | 1 |
| 4 | Purification and characterisation of epithiospecifier protein from Brassica napus : enzymic intramolecular sulphur addition within alkenyl thiohydroximates derived from alkenyl glucosinolate hydrolysis 显示文摘 | Foo H L Gronning L M Goodenough L | 2000 | FEBS Letters2000，468，： | 1 |
| 5 | A sensor fault detection and isolation method in interior permanent-magnet synchronous motor drives based on an extended Kalman filter显示文摘 | Foo G H B Zhang X Vilathgamuwa D M | 2013 | IEEE Transactions on Industrial Electronics2013，60，8： | 1 |
| 6 | Simplified apoptotic cascades 显示文摘 | MOVASSAGH M FOO R S | 2008 | Heart Fail Rev2008，13，： | 1 |
| 7 | Transplanted human fetal neural stem cells survive,migrate,anddifferentiate in ischemic rat cerebral cortex显示文摘 | Kelly S Bliss TM Shah AK Sun GH Ma M Foo WC | 2004 | Proc Natl AcadSci U S A2004，101，11： | 1 |
| 8 | Feasibility of Integrating High-Spatial-Resolution 3D Breath-hold Coronary MR Angiography with Myocardial Perfusion and Viability Examinations显示文摘 | Ho VB Saranathan M | 2005 | Radiology2005，235，3： | 1 |
| 9 | Optical vortex coronagraph显示文摘 | Foo G Palacios D M Swartzlander G A | 2005 | Opt Lett2005，30，24： | 1 |
| 10 | Boundary element method analysis of the potential field associated with a corroding electrode显示文摘 | CHERRY FOO B W SIAUW M | 1986 | Corrosion1986，42，11： | 1 |
| 11 | Direct torque control of an IPM- synchronous motor drive at very low speed using a sliding-mode stator flux observer显示文摘 | FOO G H B RAHMAN M F | 2000 | IEEE Trans on Power Electronics2000，25，4： | 1 |
| 12 | Surplus diagram and cascade analysis technique for targeting property-based material reuse network 显示文摘 | Foo D C Y Kazantzi V EI-Halwagi M M | 2006 | Chemical Engineering Science2006，61，8： | 1 |
| 13 | Active suspension control of flexible-bodied railway vehicle using electrohydraulic and electromagnetic actuators显示文摘 | FOO E GOODALL R M | 2000 | Control Engineering Practice2000，，8： | 1 |
| 14 | Direct torque control of an IPM-synchronous motor drive at very low speed using a sliding-modestator flux observer显示文摘 | Foo G H B Rahman M F | 2010 | IEEE Transactions on Power Electronics2010，25，4： | 1 |
| 15 | Characterizing the stiffness of human Prostates using acoustic radiation force 显示文摘 | Zhai L John M Foo WC | 2010 | Ultrason Ima- ging2010，32，4： | 1 |
| 16 | Cervical spinal cord injury complicating ankylosing spondylitis显示文摘 | Foo D Sarkarati M Marcelino V | 1985 | Paraplegia1985，23，6： | 1 |
| 17 | Active suspension control of flexible-bedied railway vehicle using electro-hydraulic and electromagnetic actuators显示文摘 | Foo E Goodall R M | 2000 | Control Engineering Practice2000，，8： | 1 |
| 18 | The clinical utility of brain natriuretic peptide in paediatric left ventrieular failure 显示文摘 | Mangat J Carter C Riley G Foo Y Burch M | 2009 | Eur J Heart Fail2009，11，1： | 1 |
| 19 | Effect of time, dose and fractionation on temporal lobe necrosis following radiotherapy for nasopharyngeal carcinoma显示文摘 | Lee A W M Foo W Chuppeu R | 1998 | Int J Ratiat Oncol Biol Phys1998，40，： | 1 |
| 20 | Sensor-less direct torque and flux-controlled IPM synchronous motor drive at very low speed without signal injection 显示文摘 | FOO G RAHMAN M F | 2010 | IEEE Control Automation and Systems2010，5，7： | 1 |
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