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| 1 | Contrast-enhanced ultrasound in diagnosis and characterization of focal hepatic lesions显示文摘The extensive use of imaging techniques in differential diagnosis of abdominal conditions and screening of hepatocellular carcinoma in patients with chronic hepatic diseases,has led to an important increase in identification of focal liver lesions.The development of contrastenhanced ultrasound(CEUS) opens a new window in the diagnosis and follow-up of these lesions.This technique offers obvious advantages over the computed tomography and magnetic resonance,without a decrease in its sensitivity and specificity.The new second generation contrast agents,due to their intravascular distribution,allow a continuous evaluation of the enhancement pattern,which is crucial in characterization of liver lesions.The dual blood supply in the liver shows three different phases,namely arterial,portal and late phases.The enhancement during portal and late phases can give important information about the lesion's behavior.Each liver lesion has a different enhancement pattern that makes possible an accurate approach to their diagnosis.The role of emerging techniques as a contrastenhanced three-dimensional US is also discussed.In this article,the advantages,indications and technique employed during CEUS and the different enhancement patterns of most benign and malignant focal liver lesions are discussed. | Inés Gómez Molins Juan Manuel Fernández Font Juan Carrero álvaro Jose Luís Lledó Navarro Marta Fernández Gil Conrado M Fernández Rodríguez | 2010 | World Journal of Radiology2010，2，12： | 14 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Spectral classification of water masses under the influence of the Amazon River plume显示文摘The large amount of dissolved and particulate material discharged by the Amazon River into the Equatorial Atlantic Ocean cause distinct spectral response of its waters as compared to the nearby ocean waters. This paper shows the application of K-means clustering algorithm for classifying water masses in the region under the Amazon River plume influence according to their spectral behavior. Salinity and temperature data from 67 oceanographic stations were related to Sea-viewing Wide Field-of-view Sensor (SeaWiFS) remote sensing reflectances values and the following bio-optical products: (i) chlorophyll-a concentration, (ii) water attenuation coefficient and (iii) absorption coefficient for dissolved and detrital material. Four different water masses were identified such as: (1) oceanic water, (2) intermediate oceanic water, (3) intermediate river plume water and (4) Amazon River plume water. The spectral behavior of these water masses allowed concluding that the main active optical component of the waters in the region is the colored dissolved organic matter originated mostly from the Amazon River. | Gustavo Souto Fontes Molleri Milton Kampel Evlyn Mrcia Leo de Moraes Novo | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 4 | Clusters of Clinical and immunologyic features in systemic lupus erythematosus:analysis of 600 patients from a single center显示文摘 | FONT J CERVERA R RAMOS-CASALS M | 2004 | Semin Arthritis Rheum2004，33，4： | 1 |
| 5 | Using 3D structures and their virtual representation as a tool for restoring opencast mines and quarries 显示文摘 | Pinto V Font X Salgot M | 2002 | Engineering Geology2002，63，12： | 1 |
| 6 | Effect of Fatty Acid Addition on the Properties of Biopolymer Films Based on Lipophilic Maize Starch and Gelatin 显示文摘 | F M FAKHOURI L C B FONTES L H INNOCENTINI- MEI | 2009 | Starch-Starke2009，，61： | 1 |
| 7 | The overlap of Sjsgren' s syndrome with other systemic autoimmune diseases 显示文摘 | Ramos-Casals M Brito - Zeron P Font J | 2007 | Semin Arthritis Rheum2007，36，4： | 1 |
| 8 | An imprinted antisense RNA overlaps UBE3A and a second maternally expressed transcript 显示文摘 | Rougeulle C Cardoso C Fontes M | 1998 | Nat Genet1998，19，1： | 1 |
| 9 | Determination of organochlorine pesticide residues in honey from the central zone of Portugal and the Valencian community of Spain 显示文摘 | Blasco C Lino CM Pico Y Pena A Font G Silveira M I N | 2004 | Journal of Chromatography A2004，1049，12： | 1 |
| 10 | Overexpression of FABP 7 in Down Syndrome Fetal Brain Is Associated with PKNOX1 Gene-dosage Imbalance 显示文摘 | Sanchez Font M F Bosch Comas A Marfany G | 2003 | Nuclei Acids Res2003，31，11： | 1 |
| 11 | Competitive adsorption of zinc,cadmium,copper and lead in three highly weathered Brazilian soils显示文摘 | Fontes M P F Matos A F Costa L M | 2000 | Commun Soil Sci Plant Anal2000，31，： | 1 |
| 12 | A new method for pattern recognition in load profiles to support decision-making in the management of the electric sector显示文摘 | Ferreira A M S Cavalcante C A M T Fontes C H O | 2013 | International Journal of Electrical Power&Energy Systems2013，53，： | 1 |
| 13 | Producao de biomassa e rizomas e incidência de 'Metsubure' em tarosubmetido a doses de potássio corn e sem adicao de cálcio显示文摘 | Pereira F H F Puiatti M Fontes P C R | 2006 | Horticultura Brasileira2006，24，1： | 1 |
| 14 | Deternination of penicillin-G (PG-G) in commercialised milk by reverse phase high performance liquid chromatography显示文摘 | Fontes E M martins S Carrapico B | 1996 | Toxicology Letters1996，，88： | 1 |
| 15 | Selectivity sequence and competitive adsorption of heavy metals by Brazilian soils显示文摘 | Gomes P C Fontes M P F Costa L M | 2001 | Soil Sci Soc Am J2001，65，： | 1 |
| 16 | Treat- ment of complex proximal humeral fractures with minimally inva- sive fixation of the humeral head combined with flexible intramed- ullary wire fixation-introduction of a new treatment concept 显示文摘 | Khodadadyan-Klostermann C Raschke M Fontes R | 2002 | Langenbecks Arch Surg2002，387，34： | 1 |
| 17 | Plant defense and antimicrobial peptides显示文摘 | CASTRO M S FONTES W | 2005 | Protein Pept Lett2005，12，1： | 1 |
| 18 | Column in the Solid-phase Extraction of Pesticides from Water显示文摘 | Viana ERedondo M J Font G Disks Versus | 1996 | J Chromate-grapey A1996，733，12： | 1 |
| 19 | Mycophenolate mofetil in patients with hepatitis C virus infection 显示文摘 | Ramos- Casals M Font J | 2005 | Lupus2005，14，1： | 1 |
| 20 | Kinetics of insoluble-substrate fermentation in mixed continuous-flow systems 显示文摘 | Font R Lopez J M | 1990 | Chemical Engineering Science1990，45，10： | 1 |
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