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| 1 | Histologic features and genomic alterations of primary colorectal adenocarcinoma predict growth patterns of liver metastasis显示文摘BACKGROUND Different histological growth patterns(HGPs)of colorectal carcinoma(CRC)liver metastasis are associated with patients’prognosis and response to antiangiogenic therapy.However,the relationship between HGPs of liver metastasis and clinicopathological and genomic characteristics of primary cancer has not been well established.AIM To assess whether certain clinicopathological and genomic features of primary CRC could predict the HGPs of liver metastasis.METHODS A total of 29 patients with paired resections of both primary CRC and liver metastasis were divided into two groups:A(15 cases with desmoplastic liver metastasis)and B(14 cases with replacement liver metastasis).Clinical information was obtained from patients’charts.Mismatch repair proteins,BRAFV600E,and PD-L1 were evaluated by immunohistochemistry.Five cases were selected randomly from each group for whole exome sequencing(WES)analysis.RESULTS In the primary tumor,expanding growth pattern,low tumor budding score(TBS),and Crohn’s disease-like response(CDR)were associated with desmoplastic liver metastasis and better overall survival,whereas infiltrating growth pattern alone of primary carcinoma could predict the replacement liver metastasis and worse overall survival(P<0.05).On WES analysis,primary carcinoma with desmoplastic liver metastasis showed mutations in APC(4/5);TP53(3/5);KRAS,PIK3CA,and FAT4(2/5);BRCA-1,BRCA2,BRAF,and DNAH5(1/5),whereas primary carcinoma with replacement liver metastasis showed mutations in APC and TP53(3/5);KRAS,FAT4,DNH5,SMAD,ERBB2,ERBB3,LRP1,and SDK1(1/5).CONCLUSION The HGPs,TBS,and CDR of primary CRC as well as the presence of specific genetic mutations such as those in PIK3CA could be used to predict the HGPs of liver metastasis,response to therapy,and patients’prognosis. | Jing-Bo Wu Ali Lopez Sarmiento Pierre-Olivier Fiset Anthula Lazaris Peter Metrakos Stephanie Petrillo Zu-Hua Gao | 2019 | World Journal of Gastroenterology2019，25，26： | 5 |
| 2 | The pharmacokinetics of the new short acting opioid remifentanil in healthy adult male volunteer显示文摘 | Egan TD Lemmens HJM Fiset P | 1993 | Aneesthesiology1993，79，5： | 1 |
| 3 | Automatic Road Extraction Using Fuzzy Mask Concepts显示文摘 | Solaiman B Fiset R Cavayas F | 1998 | IEEE Geoscience and Remote Sensing Symposium Proceedings1998，2，： | 1 |
| 4 | The influence of niobium on fracture toughness and abrasion resistance in high-chromium white cast irons显示文摘 | Fiset M Peev K Radulovic M | 1994 | Journal of Materials Science Letters1994，29，12： | 1 |
| 5 | The pharmacokinetics of the newshort-acting opioid remifentanil (GI87084B) in healthy adult male显示文摘 | Egan TD Lemmens H J Fiset P | 1993 | Anesthesiology1993，79，： | 1 |
| 6 | Fretting fatigue in electrical transmission lines显示文摘 | Z R Zhou A Cardou M Fiset | 1994 | Wear1994，173，： | 1 |
| 7 | Characterization and performance of laser melted AZ91D and AM60B显示文摘 | D Dube' M Fiset A Couture I Nakatsugawa | 2001 | Materials Science and Engineering2001，，299： | 1 |
| 8 | Brain imaging in research onanesthetic mechanisms:studies with propofol显示文摘 | Fiset P Plourde G Backman SB | 2005 | Prog Brain Res2005，150，6： | 1 |
| 9 | Double-layer capacitance of waste coffee ground activated carbons in an organic electrolyte 显示文摘 | THOMAS E R DENISA H J FISET E | 2009 | Electrochem Commun2009，11，5： | 1 |
| 10 | Women's decision-making needs regarding place of care at end of life显示文摘 | Murray MA O'Connor AM Fiset V | 2003 | Journal of Palliative Care2003，19，3： | 1 |
| 11 | hnRNP AI may interact simultaneously with telomeric DNA and the human telomerase rna in vitro 显示文摘 | Fiset S Chabot B | 2001 | Nucleic Acids Res2001，29，11： | 1 |
| 12 | Improvements in the metallograph of as-cast AZ91 alloy显示文摘 | MALTAISA A DUBE D FISET M | 2004 | Materials Characterization2004，52，： | 1 |
| 13 | Effect of lubricant in electrical conductor fretting fatigue显示文摘 | Zhou Z R Fiset M Cardou A | 1995 | Wear1995，189，： | 1 |
| 14 | The pharmacokinetics of the newshort - acting opioid remifentanil (GI87084B) in healthy adult male显示文摘 | Egan TD Lemmens HJ Fiset P | 1997 | West J Med1997，166，3： | 1 |
| 15 | Characterization and performance of laser melted AZ91D and AM60B显示文摘 | Dube D Fiset M Couture A | 2001 | Mater Sci Eng2001，299，： | 1 |
| 16 | The prevalence andpractice management consequences of dental fear in a major UScity显示文摘 | Milgrom Peter Fiset L Melnicks | 1988 | J Am Dent Assoc1988，116，6： | 1 |
| 17 | The pharmacokinetics of the new short-acting opioid remifentanil(GI87084B) in healthy adult male显示文摘 | Egan T D Lemmens H J Fiset P | 1993 | Anesthesiology1993，79，5： | 1 |
| 18 | Characterization and performance of laser melted AZ91D and AM60B显示文摘 | DUBE D FISET M COUTURE A | 2001 | Materials Science Engineering2001，299，： | 1 |
| 19 | The pharmacokinetics of the new short-acting opioid remifentanil(GI87084B)in healthy adult male volunteers显示文摘 | Lemmens HJ Fiset P | 1993 | Anesthesiology1993，79，： | 1 |
| 20 | Dose-dependent effects of propofol on the central processing of the thermal pain 显示文摘 | Hofbauer RK Fiset P | 2004 | Anesthesiology2004，100，： | 1 |
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