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| 1 | IMbrave150研究:免疫抑制剂治疗首次取得晚期肝细胞癌一线治疗成功显示文摘【据The New England Journal of Medicine 2020年5月报道】题:阿特朱单抗联合贝伐单抗在无法手术切除的晚期肝细胞癌中的疗效(作者Finn RS等)索拉非尼和仑伐替尼是目前晚期肝细胞癌(HCC)的标准一线治疗方案,可适当提高患者总生存率,但不良反应较多。PD-1抑制剂、阿特朱单抗(PD-L1抑制剂)以及贝伐单抗在Ⅰb期和Ⅱ期临床试验中显示出良好的客观缓解率。该研究探索了阿特朱单抗联合贝伐单抗对比单药索拉非尼治疗无法手术切除的晚期HCC的疗效和安全性。 | 刘昊天 钟鉴宏 FINN RS QIN S IKEDA M | 2020 | 临床肝胆病杂志2020，36，9： | 460 |
| 2 | Clarifying sub-genomic positions of QTLs for flowering habit and fruit quality in U.S. strawberry (Fragaria×ananassa) breeding populations using pedigree-based QTL analysis显示文摘The cultivated strawberry(Fragaria×ananassa)is consumed worldwide for its flavor and nutritional benefits.Genetic analysis of commercially important traits in strawberry are important for the development of breeding methods and tools for this species.Although several quantitative trait loci(QTL)have been previously detected for fruit quality and flowering traits using low-density genetic maps,clarity on the sub-genomic locations of these QTLs was missing.Recent discoveries in allo-octoploid strawberry genomics led to the development of the IStraw90 single-nucleotide polymorphism(SNP)array,enabling high-density genetic maps and finer resolution QTL analysis.In this study,breeder-specified traits were evaluated in the Eastern(Michigan)and Western(Oregon)United States for a common set of breeding populations during 2 years.Several QTLs were validated for soluble solids content(SSC),fruit weight(FWT),pH and titratable acidity(TA)using a pedigree-based QTL analysis approach.For fruit quality,a QTL for SSC on linkage group(LG)6A,a QTL for FWT on LG 2BII,a QTL for pH on LG 4CII and two QTLs for TA on LGs 2A and 5B were detected.In addition,a large-effect QTL for flowering was detected at the distal end of LG 4A,coinciding with the FaPFRU locus.Marker haplotype analysis in the FaPFRU region indicated that the homozygous recessive genotype was highly predictive of seasonal flowering.SNP probes in the FaPFRU region may help facilitate marker-assisted selection for this trait. | Sujeet Verma Jason D Zurn Natalia Salinas Megan M Mathey Beatrice Denoyes James F Hancock Chad E Finn Nahla V Bassil Vance M Whitaker | 2017 | Horticulture Research2017，4，1： | 10 |
| 3 | The importance of avoiding unnecessary right ventricular pacing in clinical practice显示文摘Symptomatic bradycardia is effectively treated with the implantation of a cardiac pacemaker. Although a highly successful therapy, during recent years there has been a focus on the negative effects associated with longterm pacing of the apex of the right ventricle(RV). It has been shown in both experimental and clinical studies that RV pacing leads to ventricular dyssynchrony, similar to that of left bundle branch block, with subsequent detrimental effects on cardiac structure and function, and in some cases adverse clinical outcomes such as atrial fibrillation, heart failure and death. There is substantial evidence that patients with reduced left ventricular function(LVEF) are at particular high risk of suffering the detrimental clinical effects of long-term RV pacing. The evidence is, however, incomplete, coming largely from subanalyses of pacemaker and implantable cardiac defibrillator studies. In this group of patients with reduced LVEF and an expected high amount of RV pacing, biventricular pacing(cardiac resynchronization therapy) devices can prevent the negative effects of RV pacing and reduce ventricular dyssynchrony. Therefore, cardiac resynchronization therapy has emerged as an attractive option with promising results and more clinical studies are underway. Furthermore, specific pacemaker algorithms, which minimize RV pacing, can also reduce the negative effects of RV stimulation on cardiac function and may prevent clinical deterioration. | Finn Akerstrm Miguel A Arias Marta Pachón Jesús Jiménez-López Alberto Puchol Justo Juliá-Calvo | 2013 | World Journal of Cardiology2013，5，11： | 3 |
| 4 | Subcutaneous implantable defibrillator: State-of-the art 2013显示文摘The subcutaneous implantable cardioverter-defibrillator(S-ICD)has recently been approved for commercial use in Europe,New Zealand and the United States.It is comprised of a pulse generator,placed subcutaneously in a left lateral position,and a parasternal subcutaneous lead-electrode with two sensing electrodes separated by a shocking coil.Being an entirely subcutaneous system it avoids important periprocedural and long-term complications associated with transvenous implantable cardioverter-defibrillator(TV-ICD)systems as well as the need for fluoroscopy during implant surgery.Suitable candidates include pediatric patients with congenital heart disease that limits intracavitary lead placements,those with obstructed venous access,chronic indwelling catheters or high infection risk,as well as young patients with electrical heart disease(e.g.,Brugada Syndrome,long QT syndrome,and hypertrophic cardiomyopathy).Nevertheless,given the absence of intracavitary leads,the S-ICD is unable to offer pacing(apart from shortterm post-shock pacing).It is therefore not suitable in patients with an indication for antibradycardia pacing or cardiac resynchronization therapy,or with a history of repetitive monomorphic ventricular tachycardia that would benefit from antitachycardia pacing.Current data from initial clinical studies and post-commercialization'real-life'case series,including over 700 patients,have so far been promising and shown that the S-ICD successfully converts induced and spontaneous ventricular tachycardia/ventricular fibrillation episodes with associated complication and inappropriate shock rates similar to that of TV-ICDs.Furthermore,by using far-field electrograms better tachyarrhythmia discrimination when compared to TV-ICDs has been reported.Future results from ongoing clinical studies will determine the S-ICD system’s long-term performance,and better define suitable patient profiles. | Finn Akerstrm Miguel A Arias Marta Pachón Alberto Puchol Jesús Jiménez-Lópezl | 2013 | World Journal of Cardiology2013，5，9： | 2 |
| 5 | Pathology of drug-elu-ting stents in humans:delayed healing and late thrombotic risk显示文摘 | Finn AV Farb A | 2006 | J Am CoIl Cardiol2006，48，1： | 1 |
| 6 | Click chemistry: diverse chemical function from a few good reactions显示文摘 | KOLB H C FINN M G SHARPLESS K B | 2001 | Angew Chem Int Ed2001，40，11： | 1 |
| 7 | L-lactide macromonomer synthesis initiated by new cyclic tinalkoxides functionalized for brushlike structures 显示文摘 | Ryner M Finne A Albertsson A C | 2001 | Macromolecules2001，34，21： | 1 |
| 8 | Reliability and va- lidity of cervical auscultation: a controlled comparison using videofluoroscopy 显示文摘 | Leslie P Drinnan M Finn P | 2004 | Dysphagia2004，19，4： | 1 |
| 9 | Seismic Response and Liq- uefaction of Sands显示文摘 | Finn W D Byrne P M Martin G R | 1976 | Journal 05 Geotechnical Engineering Di vision ASCE1976，102，8： | 1 |
| 10 | Concept of vulnerable/unstable plaque显示文摘 | Finn AV Nakano M Narula J | 2010 | Arterioscler Thromb Vase Biol2010，30，7： | 1 |
| 11 | The MAFT architecture for distributed fault - tolerance 显示文摘 | Kieckhafer R M Walter C J Finn A M | 1988 | IEEE Trans Computers1988，37，4： | 1 |
| 12 | Use of coupled explicit - implicit solver for calculating springback in automotive body panels显示文摘 | FINN M J GALLBRAITH P C | 1995 | J Mater Processing Tech1995，50，： | 1 |
| 13 | Cu(])-aza(bisoxazoline)-catalyzed asymmetric benzoylations显示文摘 | GISSIBL A FINN M G REISER O | 2005 | Organic Letters2005，7，12： | 1 |
| 14 | Vascular responses to drug eluting stents:Importance of delayed healing显示文摘 | Finn AV Nakazawa G Joner M | 2007 | Arterioscler hromb asc Biol2007，27，7： | 1 |
| 15 | On 'water' : unique reactivity of organic compounds in aqueous suspension 显示文摘 | NARAYAN S MULDOON J FINN M G | 2005 | Angewandte Chemie International Edition2005，44，22： | 1 |
| 16 | Coronary responses and differential mechanisms of late stentt thrombosis attributed to first-generation sirelimus- and paclitaxel-eluting stents显示文摘 | Nakazawa G Finn AV Vorpahl M | 2011 | J Am Coil Cardiol2011，57，4： | 1 |
| 17 | Click Chemistry:Diverse chemical cunction froma few good reactions显示文摘 | Finn M GSharpless K B | 2001 | Angew Chem lnt Ed2001，40，： | 1 |
| 18 | Adaptive detection mode with threshold control as a function of spatially sampled clutter- level estimates 显示文摘 | Finn H M Johnson R S | 1968 | RCA Review1968，29，9： | 1 |
| 19 | Adaptive detection mode with threshold control as a function of spatially sampled clutter-level estimates显示文摘 | Finn H M Johnson R S | 1968 | RCA Review1968，29，： | 1 |
| 20 | Pathology of drug-eluting stents in humans:Delayed healing and late thrombotic risk显示文摘 | Joner M Finn AV Farb A | 2006 | J Am Coll Cardiol2006，48，1： | 1 |
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