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| 1 | Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies显示文摘Colorectal cancer(CRC)is one of the cancer models and most of the carcinogenic steps are presently well understood.Therefore,successful preventive measures are currently used in medical practice.However,CRC is still an important public health problem as it is the third most common cancer and the fourth most frequent cause of cancer death worldwide.Nowadays,pathologic stage is a unique and well-recognized prognostic indicator,however,more accurate indicators of the biologic behavior of CRC are expected to improve the specificity of medical treatment.Angiogenesis plays an important role in the growth and progression of cancer but its role as a prognostic factor is still controversial.Probably the most important clinical implication of tumor angiogenesis is the development of anti-angiogenic therapy.The goal of this review is to critically evaluate the role of angiogenic markers,assessed by either endoglin-related microvessel density or expression of vascular endothelial growth factor family members in the CRC setting and discuss the role of these angiogenic markers in antiangiogenic therapies. | Sandra F Martins Rui M Reis Antonio Mesquita Rodrigues Fátima Baltazar Adhemar Longatto Filho | 2011 | World Journal of Clinical Oncology2011，2，6： | 9 |
| 2 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 3 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 4 | Net requirements of calcium, magnesium, sodium, phos- phorus, and potassium for growth of Nellore X Red Angus bulls, steers, and heifers显示文摘 | Chizzotti M L Filho S D C V Tedeschi L O | 2009 | Livestock Science2009，124，1： | 1 |
| 5 | Nanocasted oxides for gas phase glycerol conversion显示文摘 | LIMA C L VASCONCELOS S J S FILHO J M | 2011 | Appl Catal A: General2011，599，： | 1 |
| 6 | A randomized controlled trial comparing vaginal misoprostol versus Foley catheter plus oxytocin for labor induction 显示文摘 | MORAES FILHO O B ALBUQUERQUE R M CECATYI J G | 2010 | Acta Obstetricia et Gyriecologica Scandinavica2010，89，8： | 1 |
| 7 | Responses of Stylosanthes humilis (Fabaceae) populations to saline stress显示文摘 | Lovato M B De Lemos Filho J P Martins P S | 1999 | Environmental and Experimental Botany1999，41，： | 1 |
| 8 | Inflammatory response to different endodontic irrigating solutions 显示文摘 | TANOMARU FILHO M LEONARDO M R SILVA L A | 2002 | Int Endod J2002，35，9： | 1 |
| 9 | Chemo-enzymatic synthesis of the chiral side-chain of statins:application of an alcohol dehydrogenase catalyzed ketone reduction on a large scale 显示文摘 | Wolberg M Filho M V Bode S | 2008 | Bioprocess Biosyst Eng2008，31，： | 1 |
| 10 | Microstructure,mechanical Properties and wearresistance of high speedsteel rolls for hot rolling mills 显示文摘 | Carvalho M A De Xavier R R Filho C S P | 2002 | I& SM2002，29，1： | 1 |
| 11 | 0ptimization of mass concrete construction using genetic algorithms显示文摘 | Fairbairn E M R Silvoso M M Filho R D | | 0，，23： | 1 |
| 12 | Information Asymmetry and Traceability Incentives for Food Safety 显示文摘 | Resende - Filho M A Hurley T M | 2012 | International Journal of Production Economics2012，139，2： | 1 |
| 13 | An automated system for liquid - liquid extraction based on a new micro - batch extraction chamber with on - line detection Preconcentration and determination of copper ( Ⅱ ) 显示文摘 | DINIZ M C T FILHO O F ROHWEDDER J J R | 2004 | Anal Chim Acta2004，525，2： | 1 |
| 14 | Activity Based Costing For Production Learning显示文摘 | Pessanha Filho R C Espozel etc | 1999 | Int J Production Economics1999，，62： | 1 |
| 15 | Evidences for a multiple sex chromosome system with female heterogamety in Apareiodon affinis (Pisces:Parodontidae)显示文摘 | Filho O M Bertollo L A C Junior P M G | 1980 | Caryologia1980，，33： | 1 |
| 16 | Changes in fruit maturity indic along the harvest season in ' Algerie' loquat显示文摘 | Pinillos V Hueso J J Filho J M | 2011 | Sdentia Hortieulturae2011，129，4： | 1 |
| 17 | On systems of elliptic equations involving subcritical or critical Sobolev exponents显示文摘 | Alves C O Filho D C de M Souto M A S | 2000 | Nonlinear Analysis2000，42，： | 1 |
| 18 | A study on the modification of mesoporous mixed oxides supports for dry reforming of methane by Pt or Ru 显示文摘 | Davi C Carvalho Helvio Silvester A de Souza Josu M Filho | 2014 | Applied Catalysis A : General2014，47，： | 1 |
| 19 | Comparison of three single-phase PLL algorithms for UPS applications显示文摘 | Santos Filho R M Seixas P F Cortizo P C | 2008 | IEEE Transactions on Industrial Electronics2008，55，8： | 1 |
| 20 | Multiple sex chromosomes in the genus Hoplias(Pisces:Erythrinidae)显示文摘 | Bertollo L A C Takahashi C S Filho O M | 1983 | Cytologia1983，，48： | 1 |
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