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| 1 | Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract显示文摘Metabotropic glutamate receptor subtype 5(mGluR5) is a Group I mGlu subfamily of receptors coupled to the inositol trisphosphate/diacylglycerol pathway. Like other m Glu R subtypes, mGluR5 s contain a phylogenetically conserved, extracellular orthosteric binding site and a more variable allosteric binding site, located on the heptahelical transmembrane domain. The mGluR5 receptor has proved to be a key pharmacological target in conditions affecting the central nervous system(CNS) but its presence outside the CNS underscores its potential role in pathologies affecting peripheral organs such as the gastrointestinal(GI) tract and accessory digestive organs such as the tongue, liver and pancreas. Following identification of mGluR5s in the mouth, various studies have subsequently demonstrated its involvement in mechanical allodynia, inflammation, pain and oral cancer. mGluR5 expression has also been identified in gastroesophageal vagal pathways. Indeed, experimental and human studies have demonstrated that mGluR5 blockade reduces transient lower sphincter relaxation and reflux episodes. In the intestine, mGluR5s have been shown to be involved in the control of intestinal inflammation, visceral pain and the epithelial barrier function. In the liver, mGluR5s have a permissive role in the onset of ischemic injury in rat and mice hepatocytes. Conversely, livers from mice treated with selective negative allosteric modulators and mGluR5 knockout mice are protected against ischemic injury. Similar results have been observed in experimental models of free-radical injury and in vivo mouse models of acetaminophen intoxication. Finally, mGluR5s in the pancreas are associated with insulin secretion control. The picture is, however, far from complete as the review attempts to establish in particular as regards identifying specific targets and innovative therapeutic approaches for the treatment of GI disorders. | Andrea Ferrigno Clarissa Berardo Laura G Di Pasqua Veronica Siciliano Plinio Richelmi Mariapia Vairetti | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Liver plays a central role in asymmetric dimethylargininemediated organ injury显示文摘Asymmetric-dimethylarginine(ADMA) competes with L-arginine for each of the three isoforms of nitric oxide synthase:endothelial;neuronal;inducible.ADMA is synthesized by protein methyltransferases followed by proteolytic degradation.ADMA is metabolized to citrulline and dimethylamine,by dimethylarginine dimethylaminohydrolase(DDAH) and enters cells through cationic amino-acid transporters extensively expressed in the liver.The liver plays a crucial role in ADMA metabolism by DDAH-1 and,as has been recently demonstrated,it is also responsible for ADMA biliary excretion.A correlation has been demonstrated between plasma ADMA levels and the degree of hepatic dysfunction in patients suffering from liver diseases with varying aetiologies:plasma ADMA levels are increased in patients with liver cirrhosis,alcoholic hepatitis and acute liver failure.The mechanism by which liver dysfunction results in raised ADMA concentrations is probably due to impaired activity of DDAH due to severe inflammation,oxidative stress,and direct damage to DDAH.High plasma ADMA levels are also relevant as they are associated with the onset of multiorgan failure(MOF).Increased plasma concentration of ADMA was identified as an independent risk factor for MOF in critically-ill patients causing enhanced Intensive Care Unit mortality:a significant reduction in nitric oxide synthesis,leading to malperfusion in various organs,eventually culminating in multi organs dysfunction. | Andrea Ferrigno Laura G Di Pasqua Clarissa Berardo Plinio Richelmi Mariapia Vairetti | 2015 | World Journal of Gastroenterology2015，21，17： | 2 |
| 3 | Haemostatic abnormalities in lung cancer: prognostic implications显示文摘 | Buccheri G Ferrigno D Ginardi C | 1997 | Eur J Cancer1997，33，1： | 1 |
| 4 | Lung tumor markers in onlogy practice:a study of TPA and CA125显示文摘 | Buccheri G Ferrigno D | 2002 | Br J Cancer2002，87，10： | 1 |
| 5 | Vinorelbine in elderly patients with inoperable non-small cell lung carcinoma :a phase Ⅱ study 显示文摘 | Buechcfi G Ferrigno D | 2000 | Cancer2000，88，12： | 1 |
| 6 | Clinical equivalence of two cytokeratin markers in non-small cell lung cancer:A study of tissue polypeptide antigen and cytokeratin 19 fragments显示文摘 | Buccheri G Torchio P Ferrigno D | 2003 | Chest2003，124，2： | 1 |
| 7 | Lung tumor markers in oncology practice: a study of TPA and CA125 显示文摘 | Buccheri G Ferrigno D | 2002 | Br J Cancer2002，87，10： | 1 |
| 8 | Plasma levels of D-dimer in lung carcinoma: clinical and prognostic significance 显示文摘 | Buccheri G Torchio P Ferrigno D | 2003 | Cancer2003，97，12： | 1 |
| 9 | Prognositic significance of blood coagulation tests in lung cancer显示文摘 | FERRIGNO D BUCCHERI G RICCA I | 2001 | Eur Respir J2001，17，： | 1 |
| 10 | Clinical equivalence of two cytokeratin markers in non-small cell lung cancer:a study of tissue poly peptide antigen and cytokeratin 19 fragments显示文摘 | Buccheri G Torchio P Ferrigno D | 2003 | Chest2003，124，2： | 1 |
| 11 | Plasma levels of D-dimer in lung carcinoma:clinical and prognostic significance显示文摘 | BUCCHERI G TORCHIO P FERRIGNO D | 2003 | Cancer2003，97，： | 1 |
| 12 | Karnofsky and ECOG performance status scoring in lung cancer:a prospective,longitudinal study of 536 patients from a single institution显示文摘 | Buccheri G Ferrigno D Tamburini M | | 0，，07： | 1 |
| 13 | Prognostic significance of blood coagultion tests in lung cancer 显示文摘 | Ferrigno D Buccheri G Ricca I | 2001 | Eur Respir J2001，17，4： | 1 |
| 14 | Weeldy chemotherapy with cisplatin and paclitaxel in advanced NSCIC: a phase Ⅱ study 显示文摘 | Buccheri G Ferrigno D Giordano MC | 2006 | Monaldi Arch Chest Dis2006，65，2： | 1 |
| 15 | Weekly chemotherapy with cis-- plafin and pachtaxelin advanced NSC1C: a phase II study显示文摘 | Buccheri G Ferrigno D Giordano MC | 2006 | Monaldi Arch Chest Dis2006，65，2： | 1 |
| 16 | Lung tumor markers in onlogy practice:A study of TPA and CA125显示文摘 | Buccheri G Ferrigno D | | 0，，： | 1 |
| 17 | Weekly chemotherapy with cis- platin and paclitaxel in advanced NSCIC: a phase II study显示文摘 | Buccheri G Ferrigno D Giordanom C | 2006 | Monaldi Arch Chest Dis2006，65，2： | 1 |
| 18 | Weekly chemotherapy with cisplatin and paelitaxel in advanced NSC1C:a phaae Ⅱ study显示文摘 | Buccheri G Ferrigno D Giordano MC | 2006 | Monaldi Arch Cheat Dis2006，65，2： | 1 |
| 19 | Lung matrix metallo- proteiuase activation following partial hepatic ischemia/reperfusion injury in rats 显示文摘 | Palladini G Ferrigno A Rizzo V | 2014 | Scientific World Journal2014，，： | 1 |
| 20 | A Biaxial Probe for Nondestructive Testing on Conductive Materials显示文摘 | Bernieri A Betta G Ferrigno L | 2004 | IEEE Transactions on Instrumentation and Measurement2004，53，3： | 1 |
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