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| 1 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 2 | Histological and molecular classification of gliomas显示文摘Rev Neurol (Paris). 2008 June-July;164(6-7):505-515. Epub 2008 Jun 10.Gliomas are the most frequent tumors of the central nervous system. The WHO classification, based on the presumed cell origin,distinguishes astrocytic,oligodendrocytic and mixed gliomas. A grading system is based on the presence of the following criteria: in- | Figarella-Branger D Colin C Coulibaly B Quilichini B Maues De Paula A Fernandez C Bouvier C | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 3 | Cadmium inhibition of a structural wheat peroxidase显示文摘 | Converso D A Fernandez M E Tomaro M L | 2000 | J Enzy Inhib2000，15，： | 2 |
| 4 | Tip grafts in closed rhiiloplasty:insertion and fixation made easy显示文摘 | FERNANDEZ D E da SIL VA CARVALHO G | 2008 | Plast Reconstr Surg2008，121，3： | 1 |
| 5 | Incidence on power system dynamics of high penetration of fixed speed and doubly fed wind energy systems-study of the spanish case显示文摘 | Fernandez J L Beato D | 2002 | IEEE Transactions on Power Systems2002，17，4： | 1 |
| 6 | Determinants of innovation through a knowledge -based theory lens显示文摘 | Aranda D A Molina- Fernandez L M | 2002 | Industrial Management Data Systems2002，102，56： | 1 |
| 7 | Transition to androgen-independence in prostate cancer 显示文摘 | Navarro D Luzardo OP Fernandez L | 2002 | J Steroid Biochem Mol Biol2002，81，3： | 1 |
| 8 | Struc-ture of the FoxMl DNA-recognition domain bound to a pro-moter sequence显示文摘 | Little D R Alvarez Fernandez M Stein A | 2010 | Nucl Acids Res2010，38，13： | 1 |
| 9 | Soil and sediment phosphorus fractions in a forested watershed at Acadia National Park, ME, USA 显示文摘 | Sanclemants M D Fernandez I J Norton S A | 2009 | Forest Ecology and Management2009，258，： | 1 |
| 10 | Diagnosis and management of intramural ectopic pregnancy显示文摘 | Bannon K Fernandez C Rojas D et td | 2013 | I Minim Invasive Gynecol2013，20，5： | 1 |
| 11 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCl solution显示文摘 | Vanessa Vasconcelos Torres Roberto Salgado Amado Camila Faia de Sá Tatiana Lopez Fernandez Carlos Alberto da Silva Riehl Alexandre Guedes Torres Eliane D’Elia | 2011 | Corrosion Science2011，，7： | 1 |
| 12 | Uniportal videoassisted thoracoscopic bronchial sleeve lobectomy:first report显示文摘 | Gonzalez-Rivas D Fernandez R Fieira E | 2013 | J Thorac Cardiovasc Surg2013，145，6： | 1 |
| 13 | Esterifieation of ethylene -vinyl alcohol copolymers in homogeneous phase using N, N' - dimethylpropyleneurea as solvent 显示文摘 | FERNaNDEZ M J FERNaNDEZ M D | 2005 | Polymer2005，46，： | 1 |
| 14 | The effect of RN gene on yields and quality of extended cooked cured hams显示文摘 | Gariepy C Godbout D Fernandez X | 1999 | J Meat Science1999，52，： | 1 |
| 15 | Tobacco,alcohol, and illicit drug use in adolescents with diabetes mellitus显示文摘 | Martinez A A Araneda J C Fernandez D | 2007 | Pediatr Diabetes2007，8，5： | 1 |
| 16 | Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs显示文摘 | Sanguinetti MC Chen J Fernandez D | 2005 | Novartis Found Symp2005，266，： | 1 |
| 17 | Lignin-based formulations to prevent pesticides pollution 显示文摘 | HERRERA F J G FERNANDEZ I D PRADAS E G | 2009 | Journal of Hazardous Materials2009，168，： | 1 |
| 18 | An adaptation of the vector-space model for ontology-based information retrieval显示文摘 | CASTELLS P FERNANDEZ M VALLET D | 2007 | IEEE transactions on knowledge and data engineering2007，19，2： | 1 |
| 19 | Micropropa- gated banana infected with Meloidogyne javanica re- sponds to Glomus intraradices and phosphorus显示文摘 | Pinochet Fernandez C Jaizme M D | 1997 | Hort- science1997，32，： | 1 |
| 20 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HC1 solution 显示文摘 | TORRESS V V AMADO R S de sAC F FERNANDEZ T L da SILVA RIEHI C A TORRES A G D'ELIA E | 2011 | Corrosion Science2011，53，： | 1 |
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