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| 1 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 2 | Shared Control of Highly Automated Vehicles Using Steer-By-Wire Systems显示文摘A shared control of highly automated Steer-by-Wire system is proposed for cooperative driving between the driver and vehicle in the face of driver's abnormal driving. A fault detection scheme is designed to detect the abnormal driving behaviour and transfer the control of the car to the automatic system designed based on a fault tolerant model predictive control(MPC) controller driving the vehicle along an optimal safe path.The proposed concept and control algorithm are tested in a number of scenarios representing intersection, lane change and different types of driver's abnormal behaviour. The simulation results show the feasibility and effectiveness of the proposed method. | Chao Huang Fazel Naghdy Haiping Du Hailong Huang | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 8 |
| 3 | Differential reactivity of mouse monoclonal anti-HBs antibodies with recombinant mutant HBs antigens显示文摘AIM: To investigate the reactivity of a panel of 8 mouse anti-hepatitis B surface antigen (HBsAg) monoclonal antibodies (mAbs) using a collection of 9 recombinant HBsAg mutants with a variety of amino acid substitutions mostly located within the “a” region.METHODS: The entire HBs genes previously cloned into a mammalian expression vector were transiently transfected into COS7 cells. Two standard unmutated sequences of the ayw and adw subtypes served as controls. Secreted mutant proteins were collected and measured by three commercial diagnostic immunoassays to assess transfection efficiency. Reactivity of anti-HBs mAbs with mutated HBsAgs was determined by sandwich enzyme-linked immunosorbent assay (ELISA).RESULTS: Reactivity of anti-HBs mAbs with mutated HBsAgs revealed different patterns. While three mutants reacted strongly with all mAbs, two mutants reacted weakly with only two mAbs and the remaining proteins displayed variable degrees of reactivity towards different mAbs. Accordingly, four groups of mAbs with different but overlapping reactivity patterns could be envisaged. One group consisting of two mAbs (37C5-S7 and 35C6-S11) was found to recognize stable linear epitopes conserved in all mutants. Mutations outside the “a” determinant at positions 120 (P→S), 123(T→N) and 161(M→T) were found to affect reactivity of these mAbs.CONCLUSION: Our findings could have important implications for biophysical studies, vaccination strategies and immunotherapy of hepatitis B virus (HBV) mutants. | Azam Roohi Yaghoub Yazdani Jalal Khoshnoodi Seyed Mohammad Jazayeri William F Carman Mahmood Chamankhah Manley Rashedan Fazel Shokri | 2006 | World Journal of Gastroenterology2006，12，33： | 4 |
| 4 | Knowledge management and the entrepreneur:Insights from Ikujiro Nonaka's Dynamic Knowledge Creation model(SECI)显示文摘A key goal of knowledge management(KM)is to foster innovation through the ceation of new knowledge.Surprisingly,there is little research on KM in the context of entrepre-neurship,a domain where innovation is considered essential.This paper extends estab-lished theories and frameworks for KM to the understudied context of KM in small and medium entrepreneurial firms,particularly young startups.Translating KM fr ameworks,such as the widely studied SECI model,into the entrepreneurial domain could eventually help startups in their quest for sustainability and growth.The SECI model is an aspir ational process with which to build new knowledge,including the explicit knowledge assets that startups commonly lack.However,an aspiration is only useful if the subject knows where he or she stands in relation to it.This study focuses on understanding whether entre-preneurial activities embed into,and can further enable,the'virtuous'knowledge-creation cycle.The secondary objective of this paper is to acknowledge Ikujiro Nonaka's contribution to western and eastern KM theories,and extend his seminal theories into other domains,such as small and medium enterprises.This work pilots the use of a content analysis technique largely used in psychology to analyze the connection between entrepreneurship and KM.With this method,the study highlights how the four phases of the SECI model apply to startup firms in a business incubator in the United States.It provides insights into the knowledge-creation process of entrepreneurs,and suggests how entrepreneurs can improve startup survival through greater awareness and use of KM in their business planning and operational activities. | Cesar Bandera Fazel Keshtkar Michael R.Bartolacci Shiromani Neerudu Katia Passerini | 2017 | International Journal of Innovation Studies2017，1，3： | 4 |
| 5 | Cerebral state index versus Glasgow coma scale as a predictor for in-hospital mortality in brain-injured patients显示文摘ObjectiveTo 在预言尖锐伤害大脑的 patients.MethodsIn 的医院分泌物地位上比较格拉斯哥昏迷规模(GCS ) 和服的州的索引(CSI ) 的价值没收到 sedatives, GCS 和 CSI 的 60 个伤害大脑的病人每天在开始的 10 期间被测量;住院的天。预示的截止的点的结果被 GCS 和关于承认的时间和第三天住院操作特征(巨鸟) 曲线的 CSI 使用接收装置计算。为两个索引的敏感,特性和另外的预兆的价值是 calculated.ResultsOf 60 个估计的病人,有的 14 个病人温和,中等的有的 13 个病人和 33 个病人有严重损害。在学习的功课期间, 17 个病人(28.3%) 处于他们的状况败坏了并且死。在在住院期间死亡了的病人的吝啬的 GCS 和 CSI 比从医院被解除的那些显著地低。GCS < 4.5 并且 CSI < 64.5 在创伤的大脑损害病人与更高的死亡风险在承认的时候被联系, GCS 比 CSI 更敏感在这些病人预言在里面医院死亡。为住院的第一天,在巨鸟曲线下面的区域为 GCS 是 0.947, 0.732 为在 ICU 承认的 CSI.ConclusionGCS 分数是在里面医院死亡的一个好预言者。GCS < 4.5 并且 CSI < 64.5 在创伤的大脑损害病人与更高的死亡风险在承认的时候被联系, GCS 是比在在这些病人预言死亡的 CSI 更敏感的。 | Mehrdad Mahdian Mohammad Reza Fazel Esmaeil Fakharian Hossein Akbari Soroush Mahdian | 2014 | Chinese Journal of Traumatology2014，17，4： | 3 |
| 6 | 儿童和青少年进食障碍显示文摘进食障碍是一组疾病,是与饮食、保持体型、体重相关的不良观念伴随的行为,包括节食、暴饮暴食、锻炼过度、呕吐和使用泻药。尽管男性青少年和成人也有发生,但是进食障碍在青少年女性中更常见(图1)。进食障碍患者有高致死率和致残率,但是广泛证据显示,许多患者要么没有就诊,要么没有接受治疗。最近的指南强调了针对儿童和青少年进食障碍进行早期干预的重要性;为了达到更好的治疗效果,治疗开始得越早越好。 | Helen Bould Claudia Newbegin Anne Stewart Alan Stein Mina Fazel 张春雨(译) | 2018 | 英国医学杂志中文版2018，21，8： | 2 |
| 7 | A three dimensional CFD simulation and optimization of direct DME synthesis in a fixed bed reactor显示文摘In this study, a comprehensive three-dimensional dynamic model was developed for simulating the flow behavior and catalytic coupling reactions for direct synthesis of dimethyl ether(DME) from syngas including CO2 in a fixed bed reactor at commercial scale under both adiabatic and isothermal conditions. For this purpose, a computational fluid dynamic(CFD) simulation was carried out through which the standard k-ε model with 10% turbulence tolerations was implemented. At first, an adiabatic fixed bed reactor was simulated and the obtained results were compared with those of an equivalent commercial slurry reactor. Then the concentration and temperature profiles along the reactor were predicted. Consequently, the optimum temperature, pressure, hydrogen to carbon monoxide ratio in the feedstock and the reactor height under different operation conditions were determined. Finally, the results obtained from this three-dimensional dynamic model under appropriate industrial boundary conditions were compared with those of others available in literature to verify the model. Next, through changing the boundary conditions, the simulation was performed for an isothermal fixed bed reactor. Furthermore, it was revealed that, under isothermal conditions, the performed equilibrium simulations were done for a single phase system. Considering the simultaneous effects of temperature and pressure, the optimum operation conditions for the isothermal and adiabatic fixed bed reactors were investigated. The results of the H2+CO conversions indicated that, under isothermal condition, higher conversion could be achieved, in compared with that under adiabatic conditions. Then, the effects of various operating parameters, including the pressure and temperature, of the reactor on the DME production were examined. Ultimately, the CFD modeling results generated in the present work showed reasonable agreement with previously obtained data available in the literature.EnvironmenEtanl vpiorollnumtioennt aaln dp oiltlsu tpiroenv eanntdio ints aprere mveanjtoiro np raorbel emmasj | Fazel Moradi Mohammad Kazemeini Moslem Fattahi | 2014 | Petroleum Science2014，11，2： | 2 |
| 8 | Five New MVL Current Mode Differential Absolute Value Circuits Based on Carbon Nano-tube Field Effect Transistors(CNTFETs)显示文摘Carbon Nano-Tube Field Effect Transistors(CNTFETs) are being widely studied as possible successors to silicon MOSFETs.Using current mode has many advantages such as performing sum operation by means of a simple wired connection.Also,direction of the current can be used to exhibit the sign of digits.It is expected that the advantages of current mode approaches will become even more important with increased speed requirements and decreased supply voltage.In this paper,we present five new circuit designs for differential absolute value in current mode logic which have been simulated by CNTFET model.The considered base current for this model is 2 μA and supply voltage is 0.9 V.In all of our designs we used N-type CNTFET current mirrors which operate as truncated difference circuits.The operation of Differential Absolute Value circuit calculates the difference between two input currents and our circuit designs are operate in 8 logic levels. | Mojtaba Jamalizadeh Fazel Sharifi Mohammad Hossein Moaiyeri Keivan Navi Omid Hashemipour | 2010 | Nano-Micro Letters2010，2，4： | 2 |
| 9 | The role of nasogastric intubation on postoperative gastrointestinal function in patients with obstructive jaundice显示文摘 | Jangjoo A Mohammadipoor F Fazel A | 2012 | Indian J Surg2012，74，37： | 1 |
| 10 | Protective Role of Gallic Acid on Sodium Fluoride Induced Oxidative Stress in Rat Brain显示文摘 | Seyed Fazel Nabavi Solomon Habtemariam Mahtab Jafari | 2012 | Bulletin of Environmental Contamination and Toxicology2012，89，1： | 1 |
| 11 | Acute pancreatitis in children显示文摘 | DeBanto JR Goday PS Pedroso MR Iftikhar R Fazel A Nayyar S | 2002 | Am J Gastroenterol2002，97，7： | 1 |
| 12 | Quasi-monoenergetic laser-plasma acceleration of electrons to 2 GeV显示文摘 | Wang X Zgadzaj R Fazel N | 2013 | Nature com- munications2013，4，： | 1 |
| 13 | Robust trans-mission of MELP-compressed speech:an iilustratice example of joint source-channel decoding显示文摘 | TAHERCH FAZEL TOMAS FUJA | 2003 | IEEE Commun2003，51，6： | 1 |
| 14 | Current role of medical treatment and invasive management in carotid atheroselerotic disease显示文摘 | Fazel D Johnson K | 2008 | Proc (Bayl Univ Med Cent)2008，21，2： | 1 |
| 15 | Image analysis and reconstruction using complex Gabor wavelets显示文摘 | FAZEL R R KINSNER W | 2000 | IEEE Transactions on Signal Processing2000，3，1： | 1 |
| 16 | Guaranteed minimum- rank solutions of linear matrix equations via nuclear norm minimization显示文摘 | Recht B Fazel M Parrilo P A | 2010 | SIAM Review2010，52，3： | 1 |
| 17 | A Fuzzy Rule-Based Expert System forEvaluating Intellectual Capital 显示文摘 | Moliatnmad Hossein Fazel Zarandi Neda Mohammadhasan Susan Bastani | 2012 | Advances in Fuzzy Sys-tems2012，15，5： | 1 |
| 18 | Current role of medical treatment and invasive management in carotid atherosclerotic disease显示文摘 | Fazel P Johnson K | 2008 | Proc (Bayl Univ Med Cent)2008，21，2： | 1 |
| 19 | Robust transmission of MELPcompressed speech:An illustrative example of joint sourcechannel decoding显示文摘 | Tahereh Fazel Thomas Fuja | 2003 | IEEE Transactions on Communications2003，51，6： | 1 |
| 20 | Fuzzy agent-based expert system for steel making process显示文摘 | Fazel Zarandi M H Ahmadpour P | 2009 | Expert Systems with Applications2009，36，5： | 1 |
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