|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 2 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 3 | Frequency domain equalization for single-carrier broadband wireless systems 显示文摘 | FALCONER D ARIYAVISITAKUL S L BENYAMIN- SEEYAR A | 2002 | IEEE Communications Magazine2002，40，4： | 1 |
| 4 | Nucleotide sequence, transcriptional analysis,and expression of genes encoded within the form I CO2 fixation operon of Rhodobacter sphaeroides显示文摘 | Gibson J L Falcone D L Tabita F R | 1991 | J Biol Chem1991，266，14： | 1 |
| 5 | Effect of sili- con oxide thickness on the direct synthesis of dimethyldi- chlorosilane 显示文摘 | Seaf Yilmaz Nieole Floquet John L Falconer | 1996 | Journal of Catalysis1996，159，： | 1 |
| 6 | Frequency domain equalization for single-carrier broadband wireless systems显示文摘 | FALCONER David ARIYAVISITAKUL S L | 2002 | IEEE Communications Magazine2002，40，4： | 1 |
| 7 | Interpreting unary, binary, and ternary mixture permeation across a SAPO-34 membrane with loading-dependent Maxwell-Stefan diffusivities 显示文摘 | Li S Falconer J L Noble R D | 2007 | J Phys Chem C2007，111，： | 1 |
| 8 | Ovarian cancer risk after salpingectomy: a nationwide population-based study 显示文摘 | Falconer H Yin L Grtinberg H | 2015 | J Natl Cancer Inst2015，107，2： | 1 |
| 9 | Transparent thin-film TiO2 photocatalysts with high activity 显示文摘 | Blount M C Kim D H Falconer J L | 2001 | Environ Sci Technol2001，35，14： | 1 |
| 10 | Transient measurement of lattice oxygen in photocatalytic decomposition of formic acid on TiO_2显示文摘 | Gun Dae Lee John L Falconer | | 0，，： | 1 |
| 11 | Allostatie load is associated with chronic conditions in the Boston Puerto Rican health study显示文摘 | Mattei J Demissie S Falcon L | 2010 | Soe Sci Med2010，70，： | 1 |
| 12 | Concentration and enantiomeric ratios of organochlorine pesticides in soils from the U S cornbelt显示文摘 | Leone A D Falconer R L | 1998 | Environ Sci Tech Nol1998，，32： | 1 |
| 13 | Effects of simvastatin on cell viability and proinflammatory pathways in lung adenocarcinoma cells exposed to hydrogen peroxide显示文摘 | Gallelli L Falcone D Scaramuzzino M | 2014 | BMC Pharmacol Toxicol2014，15，： | 1 |
| 14 | Frequency domain equalization for singlecarrier broadband wireless systems 显示文摘 | Falconer D Ariyavisitakul S L Benyamin-Seeyar A | 2002 | IEEE Communications Magazine2002，40，4： | 1 |
| 15 | Separation of light gas mixtures using SAPO-34membranes显示文摘 | Poshusta J C Tuan V A Pape E A Noble R D Falconer J L | 2000 | AIChE Journal2000，46，4： | 1 |
| 16 | An unusual cause of facial swelling: primary extranodal non-Hodgkin lymphoma of the masseter muscle显示文摘 | Guastafierro S Falcone U Petrieeione L | 2011 | Am J Med Sci2011，341，： | 1 |
| 17 | 显示文摘 | KimD H Falconer J L | 2001 | Environ Sci Techno2001，35，14： | 1 |
| 18 | Silent myocardial ischemia in diabetic and nondiabetic patients with coronary artery disease显示文摘 | Falcone C Nespoli L Geroldi D | 2003 | Int J Cardiol2003，90，23： | 1 |
| 19 | An error indicator for the element free Galerkin method 显示文摘 | GAVETE L FALCON S RUIZ A | 2001 | European Journal Mechanics - A/Solids2001，20，3： | 1 |
| 20 | Separation of 1,3-propanediolfrom glycerol and glucose using a ZSM-5 zeolite membrane显示文摘 | LI S TUAN V A FALCONER J L | 2001 | J Membr Sci2001，191，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员