|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lack of Efficacy of Bevacizumab Plus Irinotecan in Children with Recurrent Malignant Glioma and Diffuse Brainstem Glioma:A Pediatric Brain Tumor Consortium Study显示文摘PURPOSE:A phase Ⅱ study of bevacizumab(BVZ) plus irinotecan(CPT-11) was conducted in children with recurrent malignant glioma(MG) and intrinsic brainstem glioma(BSG).PATIENTS AND METHODS:Eligible patients received two doses of BVZ | Gururangan S Chi SN Young Poussaint T Onar-Thomas A Gilbertson RJ Vajapeyam S Friedman HS Packer RJ Rood BN Boyett JM Kun LE | 2010 | 中国神经肿瘤杂志2010，8，2： | 7 |
| 2 | Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2. | 杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH | 2004 | Journal of Microbiology and Immunology2004，2，4： | 5 |
| 3 | In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells. | JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH | 2006 | Journal of Microbiology and Immunology2006，4，2： | 3 |
| 4 | 转染嵌合性T细胞受体基因小鼠T淋巴细胞的体外抗肿瘤作用显示文摘目的:研究小鼠T淋巴细胞在转染嵌合性T细胞受体基因后的体外抗肿瘤作用。方法:应用重组DNA技术,将HER2特异性嵌合性T-细胞受体构建入逆转录病毒载体;转入包装细胞后,收集病毒上清,转染小鼠T淋巴细胞,转基因后的小鼠T淋巴细胞分别与HER2阳性(SK-OV-3)或阴性(MCF-7)的肿瘤细胞系共培养,检测其细胞因子γ干扰素释放,51Cr释放法检测CTL评价其抗肿瘤效应。结果:所构建载体经酶切鉴定符合要求,乒乓法转染包装细胞系GP+E86,检测病毒滴度为1.2×106,Retronectin结合离心法转染经抗CD3/CD28单抗活化的小鼠T淋巴细胞,转染效率可达50%以上;转染嵌合性T细胞受体基因的T淋巴细胞与HER2阳性或阴性的肿瘤细胞系共培养后可检测到HER2特异性的细胞因子γ干扰素释放,51Cr释放法测CTL可见转染嵌合性T细胞受体基因T淋巴细胞对HER2阳性的肿瘤细胞具显著杀伤效应。结论:转染嵌合性T细胞受体基因的小鼠T淋巴细胞在体外可通过细胞因子释放和CTL效应发挥显著的抗肿瘤作用。 | 杨建民 Michael S Friedman 李峤 James J Mule Alfred E Chang Kevin T McDonagh | 2006 | 中国肿瘤生物治疗杂志2006，13，4： | 2 |
| 5 | Propping and Tunneling显示文摘 | E Friedman S Johnson and T Mitton | 2003 | Journal of Comparative Economic2003，31，4： | 1 |
| 6 | Propping and tunneling显示文摘 | Friedman E Johnson S Mitton T | 2003 | Journal of Comparative Economics2003，31，4： | 1 |
| 7 | Evaluation of coefficients for the weighted sum of gray gases model 显示文摘 | Smith T F Shen Z F Friedman J N | 1982 | ASMEJ Heat Transfer1982，，104： | 1 |
| 8 | Important causes of visual impairment in the world today显示文摘 | Congdon N G Friedman D S Lietman T | 2003 | JAMA2003，290，15： | 1 |
| 9 | The elements of statistical learning data mining, in ference and prediction 显示文摘 | HASTIE T TIBSHIRANI R FRIEDMAN J | 2005 | The mathematical intelli gencer2005，27，2： | 1 |
| 10 | Lumbar cauda equina syndrome associated with the use of Gelfoam: case report 显示文摘 | FRIEDMAN J WHITECLOUD T S 3rd | 2001 | Spine2001，26，： | 1 |
| 11 | Additive Logistic Regression: A Statistical View of Boosting显示文摘 | FRIEDMAN J HASTIE T | 2000 | The Annals of Statistics2000，28，1： | 1 |
| 12 | Pathwise coor dinate optimization显示文摘 | Friedman J Hastie T Holing H | 2007 | The Annals of Applied Statistics2007，1，2： | 1 |
| 13 | Pathwise coordinate optimization 显示文摘 | FRIEDMAN J HASTIE T HOFLING H | 2007 | The Annals of Applied Statistics2007，1，2： | 1 |
| 14 | Intravascular thrombosis in central nervous system malignancies: a potential role in astroeytoma progression to glioblastoma 显示文摘 | TEHRANI M FRIEDMAN T M OLSON J J | 2008 | Brain Pathol2008，18，2： | 1 |
| 15 | Multicast session membership size estimation显示文摘 | Friedman T Towsley D | 1999 | Proc of IEEE Infocom1999，2，3： | 1 |
| 16 | Propping and Tunneling 显示文摘 | Friedman E S Johnson T Mittton | 2003 | Journal of Comparative Economics2003，，31： | 1 |
| 17 | Propping and tunneling 显示文摘 | FriedmanE Johnson S Mitton T | 2003 | Journal of Comparative Economics2003，31，： | 1 |
| 18 | Lowering of plasma LDL cholesterol in hamsters by the tomato glycoalkaloid tomatine显示文摘 | Friedman M Fitch T E Yokoyama W E | 2000 | Food Chem Toxicol2000，38，7： | 1 |
| 19 | Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for2007 显示文摘 | Morgenthaler T Alessi C Friedman L | 2007 | Sleep2007，30，： | 1 |
| 20 | Fiber dissection technique:lateral aspect of the brain显示文摘 | Türe U Ya(s)argil MG Friedman AH | 2000 | Neurosurgery2000，47，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员