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| 1 | Late biliary complications in human alveolar echinococcosis are associated with high mortality显示文摘AIM:To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis(AE)under long-term chemotherapy with benzimidazoles.METHODS:Retrospective analysis of AE patients with biliary complications occurring more than three years after the diagnosis of AE.We compared characteristics of patients with and without biliary complications,analyzed potential risk factor for biliary complications and performed survival analyses.RESULTS:Ninety four of 148 patients with AE in Zurich had non-resectable AE requiring long-term benzimidazole chemotherapy,of which 26(28%)patients developed late biliary complications.These patients had a median age of 55.5(35.5-65)years at diagnosis of AE and developed biliary complications after 15(8.25-19)years of chemotherapy.The most common biliary complications during long-term chemotherapy were late-onset cholangitis(n=14),sclerosing cholangitis-like lesions(n=8),hepatolithiasis(n=5),affection of the common bile duct(n=7)and secondary biliary cirrhosis(n=7).Thirteen of the 26 patients had undergone surgery(including 12 resections)before chemotherapy.Previous surgery was a risk factor for late biliary complications in linear regression analysis(P=0.012).CONCLUSION:Late biliary complications can be observed in nearly one third of patients with non-resectable AE,with previous surgery being a potential risk factor.After the occurrence of late biliary complications,the median survival is only 3 years,suggesting that late biliary complications indicate a poor prognostic outcome. | Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann Rudolf W Ammann Stephan R Vavricka | 2014 | World Journal of Gastroenterology2014，20，19： | 5 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | Occurrence of 4-nonylphenol in rain and snow显示文摘 | Fries E Puttmann W | 2004 | Atmospheric environment2004，38，13： | 1 |
| 4 | Debt in industry equilibrium显示文摘 | Fries S Miller M Perraudin W | 1997 | Review of Financial Studies1997，10，1： | 1 |
| 5 | Minimum aberration 2k-p designs显示文摘 | Fries A Hunter W G | 1980 | Technometrics1980，22，： | 1 |
| 6 | Detrimental effects of epinephrine on microcirculatory blood flow in a porcine model of cardiac arrest显示文摘 | Fries M Tang W Chang YT | 2004 | Crit Care Med2004，32，12： | 1 |
| 7 | Anticancer therapy targeting the erbB family of receptor tyrosine kinases显示文摘 | Slichenmyer W J Fry D W | 2001 | Semin Oncol2001，28，16： | 1 |
| 8 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 9 | A comparison of active and passive smoking during pregnancy:long-term effects显示文摘 | Makin J Fried PA W atkinson B | 1991 | Neurotoxicol Teratol1991，13，： | 1 |
| 10 | Fast resonance-detection technique for single-frequency operation of injection-seeded Nd∶YAG lasers显示文摘 | HENDERSON S W YUEN E H FRY E S | 1986 | Opt Lett1986，11，11： | 1 |
| 11 | Spiritual Leadership as a Paradigm for Organizational Transformation and Re- covery from Extended Work Hours Cultures 显示文摘 | FRY L W COHEN M P | 2009 | Journal of Business Ethics2009，84，26： | 1 |
| 12 | Spiritual Leadership and Army Transformation : Theory, Measurement, and Establishing A Base- line 显示文摘 | Fry L W Vitucei S Cedillo M | 2005 | The Leadership Quarterly2005，16，5： | 1 |
| 13 | Renal artery aneurysms显示文摘 | Cerny J C Chang C Y Fry W J | 1968 | Arch Surg1968，96，： | 1 |
| 14 | Principle and simulation of JTIDS relative navigation显示文摘 | FRIED W R | 1978 | IEEE Trans on AES1978，14，1： | 1 |
| 15 | Prevalence,severity and importance of physical and emotional symptoms in chronic hemodialysis patients显示文摘 | W eisbord SD Fried LF Arnold RM | 2005 | J Am Soc Nephrol2005，16，： | 1 |
| 16 | Toward a Theory of Spiritual Leadership 显示文摘 | Fry L W | 2003 | Leadership Quarterly2003，14，6： | 1 |
| 17 | Isozyme characterization of sexual and asexual Phytohhthora infestans populations 显示文摘 | TOOLEY P W FRY W E VILIARREAL M J | 1985 | The Journal of Heredity1985，6，： | 1 |
| 18 | Peginterferon alfa -2a plus ribavirin for chronic hepatitis C virus infection 显示文摘 | Michael W Fried MD Mitchell L | 2002 | N Engl J Med2002，347，： | 1 |
| 19 | Measuring ^15N-NH4^+ in marine,estuarineand fresh waters:An adaption of the ammonia diffusionmethod for samples with low ammonium concentrations显示文摘 | Holmes R M McClelland J W Sigman D M Fry B Peterson B J | 1998 | Marine Chemistry1998，60，： | 1 |
| 20 | LSA and LSCA, 1956-1973: A Legislative History显示文摘 | Fry J W | 1975 | Library Trends1975，，24： | 1 |
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