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| 1 | Definition of the Portuguese frameworks with international relevance as an input for the European geological heritage characterisation显示文摘 | J. Brilha C. Andrade A. Azeredo F.J.A.S. Barriga M. Cachāo2 H. Couto P.P. Cunha J.A. Crispim P. Dantas L. V. Duarte M. C Freitas H.M. Granja M.H. Henriques P. Henriques L. Lopes J. Madeira J.M.X. Matos F. Noronha J. Pais J. Pifarra M.M. Ramalho J.M.R.S. Relvas A. Ribeiro A. Santos V.F.Santos P. Terrinha | 2005 | Episodes2005，28，3： | 5 |
| 2 | 二维导流管喷动床的流动特征显示文摘带导流管的二维喷动床(2-DSBDP)是传统喷动床的改进型式,矩形床内设置的与床同厚的垂直导流管可以控制固体颗粒的循环速率, 同时使下行区中的气固移动床维持平推流. 本文实验测定了不同表观气速、床层高度、固体颗粒与气体入口尺寸时, 二维导流管喷动床的床压降及相应的空隙率,藉以阐述2-DSBDP的流动特征. | 罗保林 Freitas L A P Lim C J Grace J R | 2000 | 化工冶金2000，21，4： | 5 |
| 3 | GISAID’s Role in Pandemic Response显示文摘GISAID is a global data science initiative and the primary source of genomic and associated metadata of all influenza viruses,Respiratory Syncytial Virus(RSV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pandemic coronavirus causing coronavirus disease 2019(COVID-19).GISAID’s publicly accessible data sharing platform enables collaboration of over 42,000 participating researchers from 198 nations and data generators from over 3,500 institutions across the globe.Since the first wholegenome sequences were made available by China CDC through GISAID on January 10. | Shruti Khare Céline Gurry Lucas Freitas Mark B Schultz Gunter Bach Amadou Diallo Nancy Akite Joses Ho Raphael TC Lee Winston Yeo GISAID Core Curation Team Sebastian Maurer-Stroh | 2021 | China CDC weekly2021，3，49： | 3 |
| 4 | Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease显示文摘This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's disease.The vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of mood.It can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous system.Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment responses.These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease.More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. | Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de Castro Brito Glauce Socorro de Barros Viana | 2023 | Neural Regeneration Research2023，18，12： | 2 |
| 5 | Structural phase relations in perovskite-structured BiFeO_(3)-based multiferroic compounds显示文摘In this review,the state of the art in understanding the structural phase relations in perovskite-structured BiFeO_(3)-based polycrystalline solid solutions is presented and discussed.Issues about the close relation between the structural phase and overall physical properties of the reviewed systems are pointed out and discussed.It is shown that,by adjusting the structural symmetric arrangement,the ferroelectric and magnetic properties of BiFeO_(3)-based polycrystalline solid solutions can be tuned to find specific multifunctional applications.However,an intrinsic mechanism linking structural arrangement and physical properties cannot be identified,revealing that this subject still deserves further discussion and investigation. | Valdirlei Fernandes FREITAS Gustavo Sanguino DIAS Otávio Algusto PROTZEK Diogo Zampieri MONTANHER Igor Barbosa CATELLANI Daniel Matos SILVA Luiz Fernando CÓTICA Ivair Aparecido dos SANTOS | 2013 | Journal of Advanced Ceramics2013，2，2： | 2 |
| 6 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 7 | Voidage and particle velocity profiles in a spout-fluid bed 显示文摘 | Pianarosa D L Freitas L Lim C J | 2000 | The Canadian Journal of Chemical Engineering2000，78，2： | 2 |
| 8 | Spray-drying of solid lipid nanopartictes (SLN)显示文摘 | Freitas C Muller R | 2008 | Fur J Pharm Biopharm2008，46，： | 1 |
| 9 | Procyanidins as antioxidants and tumor cell growth modulators 显示文摘 | Faria A Calhau C de Freitas V | 2006 | J Agric Food Chem2006，54，6： | 1 |
| 10 | Influence of the degree of polymerisation in the ability of catechins to act as anthocyanin copigments显示文摘 | Gonzilez-Manzano S Mateus N de Freitas V Santos-Buelga C | 2008 | European Food Research and Technology2008，227，： | 1 |
| 11 | Small-disturbance voltage stability of distribution systems with induction generators显示文摘 | FREITAS W DASILVA L C P MORELATO A | 2005 | IEEE Transactions on Power System2005，20，3： | 1 |
| 12 | Correlation between long - term stabili- ty of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase 显示文摘 | Freitas C Muller R | 1999 | Eur J Pharm1999，47，2： | 1 |
| 13 | A model for extremely heterogeneous clutter显示文摘 | FRERY A C MULLER H FREITAS C C | 1997 | IEEE Transactions on Geoscience and Remote Sensing1997，35，3： | 1 |
| 14 | Decomposing the decoupling of CO2 emissions and economic growth in Brazi显示文摘 | Freitas L C | 2011 | Ecological Economics2011，，6： | 1 |
| 15 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 16 | The polarimetrie G distribution for SAR data analysis 显示文摘 | Freitas C C Frery A C Correia A H | 2005 | Environmetries2005，16，1： | 1 |
| 17 | Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs显示文摘 | Freitas C F Faro R Dragosavac D | 2004 | Cardiovasc Pharmacol2004，43，1： | 1 |
| 18 | Neurite outgrowth is impaired on HSP70-positive astrocytes through a mechanism that requires NF-kappa B activation显示文摘 | de Freitas M S Spohr T C Benedito A B | 2002 | Brain Res2002，958，： | 1 |
| 19 | Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase 显示文摘 | Freitas C Muller R H | 1999 | EurJPharm Biopharm1999，47，2： | 1 |
| 20 | Source apportionment of fine and coarse particulate matter in a suburban area at the Western European Coast 显示文摘 | Almeida S M PioC A Freitas M C | 2005 | Atmospheric Environment2005，39，17： | 1 |
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