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| 1 | 中等收入国家年轻人脑卒中发病率增加:基于10年人口的研究显示文摘高收入国家年轻人脑卒中的发病率正在上升。然而,低收入和中等收入国家年轻人的脑卒中发病趋势仍未知。该研究旨在分析2005—2015年在巴西Joinville的年轻人的缺血性脑卒中(isehemic stroke,IS)和脑出血的发病趋势。 | 刘莉 叶鹏 Cabral NL Freire AT Conforto AB Dos Santos N Reis FI Nagel V Guesser VV Safanelli J Longo AL | 2017 | 中华高血压杂志2017，25，11： | 6 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 5 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 6 | Application of singular value decomposition to vertical seismic profiling显示文摘 | Freire S L M Ulrych T J | 1988 | Geophysics1988，53，6： | 1 |
| 7 | The essential oil of Eucalyptus tereticornis, and its constituents alpha-and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea 显示文摘 | Lima F J Brito T S Freire W B | 2010 | Fitoterapia2010，81，6： | 1 |
| 8 | Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia显示文摘 | Freire AT Melnyk V Kim M J | 2010 | Diagn Microbiol Infect Dis2010，68，2： | 1 |
| 9 | Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites显示文摘 | Freir D B Nicoll A J Klyubin I | | 0，，： | 1 |
| 10 | Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia 显示文摘 | Freire A T Melnyk V Kim M J | 2010 | Diagn Microbiol Infect Dis2010，68，2： | 1 |
| 11 | Geometrical nonlinearities on the static analysis of highly flexible steel cable stayed bridges 显示文摘 | Freire A Negrao J Lopes A | 2006 | Computers and Structures2006，84，32： | 1 |
| 12 | Split-step Fourier migration显示文摘 | Fokkema J T Freire R M | | Geophysics0，55，： | 1 |
| 13 | Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J | 2007 | Chest2007，131，4： | 1 |
| 14 | Stern - brocot trees in cascades of mixed - mode oscillations and canards in the extended Bonhoeffer - Van der pol and the fithugh - nagumo models of excitable systems 显示文摘 | FREIRE J G | 2011 | Physical Review Letters2011，375，7： | 1 |
| 15 | Design of europium(III) complexes with high quantum yield显示文摘 | Ricardo O. Freire Fabiana R. Gon?alves e. Silva Marcelo O. Rodrigues Maria E. de. Mesquita Nivan B. da Costa. Jùnior | 2005 | Journal of Molecular Modeling2005，，1： | 1 |
| 16 | Geometrical nonlinearities on the static analysis of highly flexible steel cable-stayed bridges 显示文摘 | Freire A M S Negrao J H O Lopes A V | 2006 | Computers and Struc- tures2006，，84： | 1 |
| 17 | Study of the diffusion coefficients of diphenylbutadiene and triclosan into and within meat显示文摘 | Sanches Silva A Freire J M C Losada P P | 2010 | European Food Research and Technology2010，230，6： | 1 |
| 18 | Early surgery for ruptured cerebral aneurysms: technical note显示文摘 | Sillero R O Sillero Filho V J Freire S B | 2007 | Arq Neuropsiquiatr2007，65，4： | 1 |
| 19 | CAD tools to optimize power MOSFET performance using channel reverse conduction显示文摘 | Castro Simas M I Freire J C | 1994 | IEEE Transactions on Power Electronics1994，9，5： | 1 |
| 20 | Structural assessment of minor axis steel joints using photoelasticity and finite elements 显示文摘 | Lima L R O Freire J L F Vellasco P C G S | 2009 | Journal of Constructional Steel Research2009，65，2： | 1 |
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