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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states显示文摘 | Schmid A W Freir D B Herron C E | 2008 | Brain research2008，1197，： | 1 |
| 3 | Nanoscale friction and wear mechanisms at the interface between a boron carbide film and an atomic force microscope tip 显示文摘 | PRIOLI R REIGADA D C FREIRE F L | 2000 | Journal of Applied Physics2000，87，3： | 1 |
| 4 | Production of Coated Papers with Improved Properties by Using a Water-soluble Chitosan Derivative显示文摘 | FERNANDES S C M FREIRE C S R SILVESTRE A J D | 2010 | Ind Eng Chem Res2010，49，14： | 1 |
| 5 | A New Procedure for Treatment of Oily Slurry Using Geotextile Filters 显示文摘 | Mendoncaa M B Cammarotab M C Freire B D | 2004 | Journal of Hazardous Materials2004，110，： | 1 |
| 6 | Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites显示文摘 | Freir D B Nicoll A J Klyubin I | | 0，，： | 1 |
| 7 | Fishing down Brazilian marine food webs,with emphasis on the east Brazil large marine ecosystem显示文摘 | FREIRE K M F PAULY D | 2010 | Fisheries Research2010，105，1： | 1 |
| 8 | Correlation between nano-scale friction and wear of boron carbide films deposited by dc-magnetron sputtering显示文摘 | Prioli R Reigada D C Freire F L | 1999 | Appl Phys Lett1999，75，9： | 1 |
| 9 | Part 3 : Burst tests of pipeline with extensive longitudinal metal loss 显示文摘 | Freire J L F Vieira R D Castro J T P | 2006 | Experimental Techniques2006，30，6： | 1 |
| 10 | Bloodstream infection caused by extensively drag-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia显示文摘 | Freire M P de Oliveira Garcia D Garcia C P | 2015 | Clin Microbiol Infect2015，，： | 1 |
| 11 | Applications and Market of PVC for Piping Industry显示文摘 | Martins J D Freire E Hemadipour H | | 0，，01： | 1 |
| 12 | Direct electron transfer: an approach for electrochemical biosensors with higher selectivity and sensitivity显示文摘 | FREIRE R S PESSOA C A MELLO L D | 2003 | J Braz Chem Soc2003，14，2： | 1 |
| 13 | A new procedure for treatment of oily slurry using geo- textile filters显示文摘 | MENDONCA M B CAMMAROTA M C FREIRE D D C | 2004 | Journal of Hazardous Materials2004，110，： | 1 |
| 14 | A review on hydrolytic enzymes in the treatment of wastewater with high oil and grease content显示文摘 | Cammarota M C Freire D M G | 2006 | Bioresource Technology2006，97，17： | 1 |
| 15 | A review on hydrolytic enzymes in the treatment of wastewater with high oil and grease content 显示文摘 | CAMMAROTA M C FREIRE D M G | 2006 | Bioresource Technology2006，97，17： | 1 |
| 16 | Experimental techniques in the field of pipeline integrity显示文摘 | Freire J L F Vieira R D Benjamin A C | 2003 | Experimental Techniques2003，，5： | 1 |
| 17 | G|ucocorticoid-induced myopathy 显示文摘 | PEREIRA R M FREIRE D E CARVALHO J | 2011 | Joint Bone Spine2011，78，1： | 1 |
| 18 | 显示文摘 | Tome L C Mecerreyes D Freire C S R | 2013 | Journal of Membrane Science2013，428，： | 1 |
| 19 | Dietary fat is as- sociated with metabolic syndrome in Japanese Brazilians显示文摘 | Freire R D Cardoso M A Gimeno S G | 2005 | Diabetes Care2005，28，7： | 1 |
| 20 | Burst tests of pipeline with extensive longitudinal metal loss显示文摘 | Freire J L F Vieira R D Benjamin A C | 2006 | ExperimentalTechniques2006，，11： | 1 |
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