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| 1 | The Need of Industry to Go FAIR显示文摘The industry sector is a very large producer and consumer of data,and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services.As many of the data sources needed are distributed and outside the company,FAIR data will have a major impact,both by reducing the existing internal data silos and by enabling the efficient integration with external(public and commercial)data.Many companies are still in the early phases of internal data”FAIRification”,providing opportunities for SMEs and academics to apply and develop their expertise on FAIR data in collaborations and public-private partnerships.For a global Internet of FAIR Data&Services to thrive,also involving industry,professional tools and services are essential.FAIR metrics and certifications on individuals,data,organizations,and software,must ensure that data producers and consumers have independent quality metrics on their data.In this opinion article we reflect on some industry specific challenges of FAIR implementation to be dealt with when choices are made regarding”Industry GOing FAIR”. | Herman van Vlijmen Albert Mons Arne Waalkens Wouter Franke Arie Baak Gerbrand Ruiter Christine Kirkpatrick Luiz Olavo Bonino da Silva Santos Bert Meerman Renger Jellema Derk Arts Martijn Kersloot Sebastiaan Knijnenburg Scott Lusher Rudi Verbeeck Jean-Marc Neefs | 2020 | Data Intelligence2020，2，1： | 4 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | A greedy Delaunay-based surface reconstruction algorithm显示文摘 | David Cohen-Steiner Frank Da | 2004 | The Visual Computer2004，，1： | 2 |
| 4 | Metageno- mic approaches for defining the pathogenesis of inflammatory bowel diseases显示文摘 | Peterson DA Frank DN Pace NR | 2008 | Cell Host Microbe2008，3，6： | 1 |
| 5 | Pregnancy affects cellular activity,but not tissue mechanical properties,in the healing rabbit medial collateral ligament显示文摘 | Hart DA Reno C Frank CB | 2000 | J Orthop Res2000，18，3： | 1 |
| 6 | Developmental origin of polycystic ovary syndrome A hypothesis显示文摘 | Abbott DH Dumesic DA Franks S | 2002 | J Endocrinol2002，174，1： | 1 |
| 7 | Plant rhizospheric N processes: what we don’t know and why we should care 显示文摘 | Frank DA Groffman PM | 2009 | Ecology2009，90，6： | 1 |
| 8 | Targeting the cytoplasmic and nuclear functionsof signal transducers and activators of transcription 3 for Cancertherapy显示文摘 | Germain D Frank DA | 2007 | Clin Cancer Res2007，13，19： | 1 |
| 9 | STAT5 activation contributes to growth and viability in Bcr/Abl transformed cells 显示文摘 | Sillaber C Gesbert F Frank DA | 2000 | Blood2000，95，6： | 1 |
| 10 | STAT5 activationcontributes to growth and viability in Bcr-Abl-transformed cells 显示文摘 | Sillaber C Gesbert F Frank DA | 2000 | Blood2000，95，6： | 1 |
| 11 | STAT signaling in the pathogenesis and treatment of cancer显示文摘 | | 1999 | Mol Med1999，5，： | 1 |
| 12 | The natural product HNK induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) ceils 显示文摘 | Battle TE Arbiser J Frank DA | 2005 | Blood2005，106，69： | 1 |
| 13 | STAT signaling in the pathogenesis and treatment of leukemias显示文摘 | Lin TS Mahajan S Frank DA | 2000 | Oncogene2000，19，15： | 1 |
| 14 | Interleukin 2 signaling involves the phosphorylation of Stat proteins显示文摘 | Frank DA Robertson MJ Bonni A | 1995 | Proc Nat Acad Sci USA1995，92，17： | 1 |
| 15 | Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancertherapy 显示文摘 | Germain D Frank DA | 2007 | Clin Cancer Res2007，13，19： | 1 |
| 16 | Level of prenatal cocaine exposure and scores on the Bayley Scales of Infant Development: modifying effects of caregiver, early intervention, and birth weight显示文摘 | Frank DA Jacobs RR Beeghly M | 2002 | Pediatrics2002，110，： | 1 |
| 17 | Developmental o- rigin of polycystic ovary syndrome A hypothesis显示文摘 | Abbott DH Dumesic DA Franks S | 2002 | J En- docrinol2002，174，1： | 1 |
| 18 | The role of STATs in apoptosis显示文摘 | Battle TE Frank DA | 2002 | Curr Mol Med2002，2，4： | 1 |
| 19 | Prevalence of intermittent claudication and risk factors for its develop- ment in patients on renal replacement therapy 显示文摘 | Webb AT Franks PJ Reaveley DA | 1993 | Eur J Vasc Surg1993，7，5： | 1 |
| 20 | STAT signaling in the pathogenesis and treatment of leukemias显示文摘 | Mahajan S Frank DA | 2000 | Oncogene2000，19，： | 1 |
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