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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 3 | The aroma of Brazilian ambarella fruit (Spondias cythereu Sonnerat) 显示文摘 | Fraga S R G Rezende C M | 2001 | Journal of Essential Oil Research2001，13，： | 1 |
| 4 | Multi-detection method for five common microalgal toxins based on the use of micro- spheres coupled to a flow-cytometry system显示文摘 | Fraga M Vilarifio N Louzao M C | 2014 | Analytica Chimi- ca Acta2014，850，： | 1 |
| 5 | Procyani- dins can interact with Caco-2 cell membrane lipid rafts: in- volvement of cholesterol显示文摘 | Verstraeten S V Jaggers G K Fraga C G | 2013 | Biochim Biophys Acta2013，1828，11： | 1 |
| 6 | Self-diffusion of liquid zinc显示文摘 | NACHTRIEB N H FRAGA E WAHL C | 1963 | J Phys Chem1963，67，11： | 1 |
| 7 | Plant polyphenols : how to translate their in vitro antioxidant actions to in vivo conditions 显示文摘 | Fraga C G | 2007 | IUBMB Life2007，59，45： | 1 |
| 8 | Two novel abietane dimers from transformed root cultures of Salvia broussonetii 显示文摘 | Fraga B M Dfaz C E L6pez-Rodrfguez M | 2014 | Tetrahedron Lett2014，55，： | 1 |
| 9 | Comparison be- tween warm blood and crystalloid cardioplegia during open heart surgery显示文摘 | Ferrira R Fraga C Carrasquedo F | 2003 | Int J Cardiol2003，90，23： | 1 |
| 10 | Curing kinetics of the epoxy system diglycidyl ether of bisphenol A/isophoronddiamine by Fourier transform infrared spectroscopy显示文摘 | Francisco Fraga Eva C Vazquez Eugenio Rodríguez-Núez | 2008 | Polym Adv Technol2008，19，： | 1 |
| 11 | Synthesis and pharmacological evaluation of novel heterotricyclic aeylhydrazone derivatives, designed as PAF antagonists显示文摘 | FRAGA A G M RODRIGUES C R MIRANDA A L P | 2000 | European Journal of Pharmaceutical Sciences2000，11，： | 1 |
| 12 | Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets显示文摘 | Cheng K Fraga D Zhang C | 2004 | Gene Ther2004，11，14： | 1 |
| 13 | Bronchoscope and tracheotomy removal of bronchial foreign body显示文摘 | Fraga J C Neto A M Seitz E | 2002 | J Pediatr Surg2002，37，8： | 1 |
| 14 | How Green is Your Hybrid? 显示文摘 | DE FRAGA C | 2007 | Royal Au- to2007，，4： | 1 |
| 15 | Inhibition of angiotensin converting enzyme activity by flavanol-rich foods 显示文摘 | Actis-Goretta L Ottaviani J Fraga C | 2006 | Journal of Agricultural and- Food Chemistry2006，54，： | 1 |
| 16 | Effects of continuous light exposure on antioxidant enzymes, porphyric enzymes and cellular damage in the Harderian gland of the Syrian hamster显示文摘 | Tomas Zapico C Coto Montes A Martinez Fraga J | 2003 | J Pineal Res2003，34，1： | 1 |
| 17 | Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets显示文摘 | Cheng K Fraga D Zhang C | 2004 | Gene Ther2004，11，14： | 1 |
| 18 | Ultrastructural evidence of increased tolerance of hibernating myocardium to cardioplegic ischemia-reperfusion injury显示文摘 | Milei J Fraga C G Grana D R | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 19 | Inhibition of anglotensin converting enzyme activity by flavanol-rich foods 显示文摘 | Actis-Goretta L Ottavlanl J I Fraga C G | 2006 | Journal of Agricultural and Food Chemistry2006，54，： | 1 |
| 20 | Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes显示文摘 | Oteiza P l Olin K L Fraga C G Keen CL | 1995 | Journal of Nutrition1995，，125： | 1 |
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