|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Combination therapy in chronic hepatitis B显示文摘 | Fournier C Zoulim F | 2008 | Gastroenterol Clin Biol2008，32，12： | 1 |
| 3 | X-ray spectroscopy with elliptical crystals and face-on framing cameras显示文摘 | Heeter R F Emig J A Fournier K B | 2004 | Review of Scientific Instruments2004，75，10： | 1 |
| 4 | A lowpower inductorless LNA with double enhancement in130 nm CMOS 显示文摘 | BELMAS F HAMEAU F FOURNIER J M | 2012 | IEEE J Sol Sta Circ2012，47，5： | 1 |
| 5 | The structural and radiative consistency of three -dimensional tree reconstruc- tions from terrestrial lidar显示文摘 | Coto J F Widlowski J L Fournier R A | 2009 | Remote Sensing of Environment2009，115，5： | 1 |
| 6 | Airway obstruction, chronic expectoration and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils显示文摘 | Stanescu D Fournier M Lebargy F | 1996 | Thoax1996，51，3： | 1 |
| 7 | Immunocytachemical detection of Ig-positive cells in blood,lymphoid organs and the gut associated lymphoid tissue of the burbot(Scophthalmus maximus)显示文摘 | FOURNIER B V QUENTEL C LAMOUR F | 2000 | Fish Shellfish Immunol2000，10，2： | 1 |
| 8 | Outcome and treatment of Bartonella endocarditis 显示文摘 | Raoult D Fournier P E Vandenesch F | 2003 | Arch Intern Med2003，163，： | 1 |
| 9 | Fast freeform reflector generation using source-target maps显示文摘 | FOURNIER F R CASSARLY W J ROLLAND J P | | 0，，05： | 1 |
| 10 | Unequal risks for hreast cancer associated with different hormone replacement therapies: re- suits from the E3N cohort study显示文摘 | Fournier A Berrino F Clavel-Chapelon F | 2008 | Breast Cancer Res Treat2008，107，1： | 1 |
| 11 | Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients显示文摘 | Nseir S Zerimech F Fournier C | 2011 | Am J Respir Crit Care Med2011，184，10： | 1 |
| 12 | Patient tolerance of transrectal ultrasound-guided biopsy of the prostate显示文摘 | Irani J Fournier F Bon D | 1997 | Br J Urol1997，79，4： | 1 |
| 13 | Fast freeform reflector generation using source-target maps显示文摘 | Fournier F R Cassarly W J Roll J P | 2010 | Optics Express2010，18，5： | 1 |
| 14 | Sable Circadian Mechanisms of Toxicity of Two Platinum Analogs (Cisplatin and Carboplatin) Despite Repeated Dosages in Mice 显示文摘 | Lévi F Fournier C | 1990 | J Pharmacol Exp Ther1990，255，2： | 1 |
| 15 | Simulation of Radon Transport through Building Materials: Influence of the Water Con- tent on Radon Exhalation Rate显示文摘 | Fournier F Groetz JE Jacob F | 2005 | Transp Porous Med2005，59，： | 1 |
| 16 | Immunocytochemical detection of Ig-positive cells in blood,lymphoid organs and the gut associated lymphoid tissue of the turbot (Scophthalmus maximus)显示文摘 | Fournier B V Quentel C Lamour A F | 2000 | Fish & Shellfish Immunology2000，10，2： | 1 |
| 17 | Excess dietary arginine affects urea excretion but does not improve N utilisation in rainbow trout Oncorhynchus rnykiss and turbot Psetta maxima 显示文摘 | FOURNIER V GOUILLOU-COUSTANS M F MtTAILLER R | 2003 | Aquaculture2003，217，234： | 1 |
| 18 | Patient tolerance of transrectal ultrasound-guided biopsy of the prostate显示文摘 | LRANI J FOURNIER F BON D | 1997 | Br J Urol1997，79，： | 1 |
| 19 | Adenoid cystic carcinoma of the breast: clinical, histological and immunohistochemical characterization 显示文摘 | Defaud-Henon F Tunon-de-Lara C Fournier M | 2010 | Ann Pathol2010，30，： | 1 |
| 20 | Chemical demilitarization: Disposing of the most hazardous wastes 显示文摘 | RIFE R THOMAS T NORBERG D FOURNIER R RINKER F BONOMO M | 1989 | Environmental Progress1989，8，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员