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| 1 | Current knowledge and future directions of TLR and NOD signaling in sepsis显示文摘The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack of normal immune homeostatic functions and excessive production of proinflammatory cytokines, which leads to multi-organ failure. The Toll-like receptor(TLR) family, one of whose members was initially discovered in Drosophila, performs an important role in the recognition of microbial pathogens. These pattern recognition receptors(PRRs), upon sensing invading microorganisms, activate intracellular signal transduction pathways. NOD signaling is also involved in the recognition of bacteria and acts synergistically with the TLR family in initiating an efficient immune response for the eradication of invading microbial pathogens. TLRs and NOD1/NOD2 respond to different pathogenassociated molecular patterns(PAMPs). Modulation of both TLR and NOD signaling is an area of research that has prompted much excitement and debate as a therapeutic strategy in the management of sepsis. Molecules targeting TLR and NOD signaling pathways exist but regrettably thus far none have proven efficacy from clinical trials. | Niamh M Foley Jian Wang H Paul Redmond Jiang-Huai Wang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，4： | 2 |
| 2 | Computed tomography angiography:principles and clinical applications显示文摘 | Foley WD Karcaaltincaba M | 2003 | J Comput Assist Tomogr2003，27，1： | 1 |
| 3 | ACE gene I/D polymorphism and sarcoidosis pulmonary disease sererity显示文摘 | Mcgrath DS Foley PJ Petrek M | 2001 | Am J Respir Crit Care Med2001，164，： | 1 |
| 4 | A randomized placebo -control trial of fluvastatin for prevention of restenoeie after successful coronary ballon angioplasty:final resuils of the fluvastatin angiographic restenosis(FLARE) trial显示文摘 | Serruys PW Foley DP Jackson G Bonnier H Macaya C Vrolix M | 1999 | Eur Heart J1999，20，： | 1 |
| 5 | Persistent inb i',ition of neoin- timal hyperplasia after sirolimus-eluting stent implantation :long-term (up to 2 years) clinical, angiographic ,and intravascular ultrasound follow-up显示文摘 | Degertekin M Serruys PW Foley DP | 2002 | Circulation2002，106，13： | 1 |
| 6 | Food animal associatedSalmonella chal lenges: pathogenicity and antimicrobial resistance 显示文摘 | Foley S L Lynne A M | 2008 | J Anita Sci2008，86，： | 1 |
| 7 | Rapid and sim- ple method for isolating malaria DNA from fingerprick samples of blood显示文摘 | Foley M Ranford-Cartwright LC Babiker HA | 1992 | Mol Biochemi Parasitol1992，53，12： | 1 |
| 8 | MAO-B inhibi- tors : multiple roles in the therapy of neurodegenerative dis- orders? 显示文摘 | Foley P Gerlach M Youdim M B | 2000 | Parkinsonism & Related Disorders2000，6，1： | 1 |
| 9 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 10 | Microendoscopic discectomy显示文摘 | Foley K Smith M | 1997 | Techn Neurosurg1997，3，： | 1 |
| 11 | Organizational learning and dynamic marketing capabilities: Implications for organizational performance 显示文摘 | Foley L M Vorhies D W Bush V D | 2005 | AMA Winter Educators'' Conference Proceedings2005，，16： | 1 |
| 12 | Rapid and simple method for isolating malaria DNA from fingerprick samples of blood显示文摘 | Foley M Ranford-Cartwright LC Babiker HA | 1992 | Mol Biochem Parasitol1992，70，： | 1 |
| 13 | In vitro propagation and transcriptional profiling of humanmammary stem/progeni- tor cells显示文摘 | Dontu G Abdallah W M Foley J M etal | 2003 | Genes Dev2003，17，10： | 1 |
| 14 | Human luminance pattern-vision mecha- nisms-masking experiments require a new model 显示文摘 | FOLEY J M | 1994 | Journal of the Optical Society of America a-Optics Image Science and Vision1994，11，6： | 1 |
| 15 | An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of phase II and III clinical trials 显示文摘 | Ligueros-Saylan M Foley JE Schweizer A | 2010 | Diabetes Obes Metab2010，12，6： | 1 |
| 16 | Knowing when to grow:signals regulating bud dormancy显示文摘 | HORVATH D P ANDERSON J V CHAO W S FOLEY M E | 2003 | Trends in Plant Science2003，8，： | 1 |
| 17 | The polymorphic nature of HIV type 1 env V4 affects the patterns of potential N-glycosylation sites in proviral DNA at the intrahost level显示文摘 | Belair M Dovat M Foley B | | 0，，2： | 1 |
| 18 | Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones,islet function,and postprandial glycemia in subjects with impaired glucose tolerance显示文摘 | Rosenstock J Foley J E Rendell M | 2008 | Diabetes Care2008，31，1： | 1 |
| 19 | Electrochemical reduc- tion of 5-chloro-2- (2,4-dichlorophenoxy)phenol (triclosan) in dimethylformamide显示文摘 | Knust K N Foley M P Mubarak M S | 2010 | Journal of Electroanalytical Chemistry2010，638，10： | 1 |
| 20 | Visualizing and modeling unstructured data显示文摘 | Foley T A Hagen H Nielson G M | 1993 | The Visual Computer International Journal of Computer Graphics1993，9，8： | 1 |
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