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| 1 | Coarctation of the aorta:Management from infancy to adulthood显示文摘Coarctation of the aorta is a relatively common form of congenital heart disease, with an estimated incidence of approximately 3 cases per 10000 births. Coarctation is a heterogeneous lesion which may present across all age ranges, with varying clinical symptoms, in isolation, or in association with other cardiac defects. The first surgical repair of aortic coarctation was described in 1944, and since that time, several other surgical techniques have been developed and modified. Additionally, transcatheter balloon angioplasty and endovascular stent placement offer less invasive approaches for the treatment of coarctation of the aorta for some patients. While overall morbidity and mortality rates are low for patients undergoing intervention for coarctation, both surgical and transcatheter interventions are not free from adverse outcomes. Therefore, patients must be followed closely over their lifetime for complications such as recoarctation, aortic aneurysm, persistent hypertension, and changes in any associated cardiac defects. Considerable effort has been expended investigating the utility and outcomes of various treatment approaches for aortic coarctation, which are heavily influenced by a patient's anatomy, size, age, and clinical course. Here we review indications for intervention, describe and compare surgical and transcatheter techniques for management of coarctation, and explore the associated outcomes in both children and adults. | Rachel D Torok Michael J Campbell Gregory A Fleming Kevin D Hill | 2015 | World Journal of Cardiology2015，7，11： | 27 |
| 2 | 利用RNA干扰技术抑制水稻淀粉极限糊精酶基因表达显示文摘构建了含极限糊精酶基因片段反向重复结构的RNAi载体,抑制水稻籽粒中极限糊精酶基因表达获得了极限糊精酶基因功能缺失突变体。经酶切及序列测定证实,成功地构建了胚乳特异表达启动子启动的水稻极限糊精酶基因反向重复结构RNAi载体;通过根癌农杆菌(Agrobacterium tumefaciens)介导水稻(Oryza sativa sp.japonica)转化,经PCR及Southern杂交检测,获得28个水稻转基因再生株系;以极限糊精酶抗体对转基因株系胚乳发育期籽粒蛋白质进行Western杂交,并经SDS-PAGE极限糊精酶活性检测,结果显示,该反向重复结构在胚乳发育期表达,减少了极限糊精酶的积累,获得了不同沉默效果的转基因株系。转化株系012的极限糊精酶活性只有野生型的10%,表明该载体可有效地抑制水稻胚乳中极限糊精酶的活性。 | 黄冰艳 李忠谊 吉万全 海燕 Fleming J Morell M Rahman S | 2007 | 农业生物技术学报2007，15，1： | 13 |
| 3 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 4 | An overview of evolutionary algorithm in multi-objective optimization显示文摘 | Fonseca C M Fleming P J | 1995 | Evolutionary Computation1995，3，1： | 1 |
| 5 | Safety and tolerability of BufferGel,a novel vaginal microbicide,in women in the United显示文摘 | Peipert J Fleming T | 2001 | Clin Infect Dis2001，32，3： | 1 |
| 6 | An overview of evolutionary algorithms in multi-objective optimization显示文摘 | Fonseca C M Fleming P J | 1995 | Evolutionary Computation1995，3，1： | 1 |
| 7 | A program for longitu- dinal load analysis of electric transmission lines显示文摘 | Fleming J F Athins R S Mozer J D | 1978 | Comput- ers and Structures1978，9，3： | 1 |
| 8 | Prospective Memory Rehabilitation for Adults with Traumatic Brain Injury:A Compensatory Training Programme显示文摘 | FLEMING JM SHUM D STRONG J | 2005 | Brain Injury (S0269-9052)2005，19，1： | 1 |
| 9 | IGF-I dif- ferentially regulates IGF-binding protein expression in primary mammary fibroblasts and epithelial cells 显示文摘 | Fleming J M Leibowitz B J Kerr D E | 2005 | J Endocrinol2005，186，1： | 1 |
| 10 | Effect of proline onthe antimicrobial mechanism of buforin D 显示文摘 | Xie Y Fleming E Chen J | 2011 | Peptides2011，32，4： | 1 |
| 11 | Dis- tributed aero-engine control systems architecture selectio- nusing multi-objective optimization显示文摘 | Thompson H A Chipperfiled A J Fleming P J | 1999 | Control Engineer- ing Practice1999，7，5： | 1 |
| 12 | Auditor Industry Specialization, Auditor Changes, and Accounting Restatements显示文摘 | Romanus RN Maher J J Fleming DM | 2008 | Accounting Horizons2008，22，4： | 1 |
| 13 | Fuzzy scheduling control of a gas turbine aero-engine:a multiobjective approach显示文摘 | Chipperfield A J Bica B Fleming P J | 2002 | IEEE Transactions on Industrial Electronics2002，49，3： | 1 |
| 14 | Observations on the junction of the fresh waters of rivers with the salt water of the sea显示文摘 | Fleming J | | Transactions of the Royal Society of Edinburgh0，8，： | 1 |
| 15 | Treatment of older patients with head and neck cancer: a review 显示文摘 | VanderWalde NA Fleming M Weiss J | 2013 | Onco- logist2013，18，5： | 1 |
| 16 | Comparison of in- dividual,group and combined intervention formats in a randomized controlled trial for facilitating goal attain- ment and improving psychosocial function following ac- quired brain injury显示文摘 | Ownsworth T Fleming J Shum D | 2008 | J Rehabil Med2008，40，2： | 1 |
| 17 | Unbalance Response Prediction for Rotors on Ball Bearings Using Speed and Load Dependent Nonlinear Bearing Stiffness 显示文摘 | Fleming D P Poplawski J V | 2005 | International Journal of Rotating Machinery2005，，1： | 1 |
| 18 | Improved procedures for the reductive coupling of carbonyls to olefins and for the reduction of diols to olefins显示文摘 | McMurry J E Fleming M P | 1976 | J Org Chem1976，41，5： | 1 |
| 19 | Nonlinear static analysis of cable-stayed bridge structures 显示文摘 | Fleming J F | 1979 | Computers and Structures1979，10，： | 1 |
| 20 | Effect of tension and placement of a prosthetic anterior cruciate ligament of the anteroposterior laxuty of the knee 显示文摘 | Fleming B Beynnon B Howe J | 1992 | Orthopaedic Research1992，10，： | 1 |
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