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| 1 | Aetiology of idiopathic granulomatous mastitis显示文摘Idiopathic granulomatous mastitis is a rare chronic inflammatory lesion of the breast that can clinically and radiographically mimic breast carcinoma. The most common clinical presentation is an unilateral, discrete breast mass, nipple retraction and even a sinus formation often associated with an inflammation of the overlying skin. The etiology of idiopathic granulomatous mastitis is still obscure. Its treatment remains controversial. The cause may be the autoimmune process, infection, a chemical reaction associated with oral contraceptive pills, or even lactation. Various factors, including hormonal imbalance, autoimmunity, unknown microbiological agents, smoking and α 1-antitrypsin deficiency have been suggested to play a role in disease aetiology. In this review, causing factors in the aetiology of idiopathic granulomatous mastitis are reviewed in detail. | Fatih Altintoprak Taner Kivilcim Orhan Veli Ozkan | 2014 | World Journal of Clinical Cases2014，2，12： | 52 |
| 2 | 深度残差网络的多光谱遥感图像显著目标检测显示文摘本文侧重于介绍智能化摄影测量深度学习的深度残差方法。显著目标检测致力于自动检测和定位图像中人最感兴趣的目标区域。多波段遥感图像因其更加丰富的光谱信息和揭示观测目标物理属性的能力在目标检测中获得重要应用。传统的显著目标检测方法通过手工设计特征,计算图像各像素或者超像素与邻域像素或者超像素之间的对比度检测显著目标。随着深度学习的巨大发展,特别是全卷积神经网络的引入,基于深度卷积网络的显著目标检测算法取得重要进步。然而,由于数据获取和标记的困难,多波段遥感图像显著目标检测的研究依然主要采用手工设计特征。本文研究基于深度卷积神经网络的多波段遥感图像显著目标检测算法,提出一种基于深度残差网络的自上而下的多光波段遥感图像显著目标检测网络,该网络可以有效挖掘深度残差网络不同层次上的显著性特征,以端对端方式实现显著目标检测。为了应对多波段遥感图像数据量有限、无法训练深度残差网络的问题,本文提出通过浅层神经网络从RGB图像直接生成多波段遥感图像,实现光谱方向的超分辨率。在现有多波段遥感图像和可见光图像显著目标检测数据集上的试验结果超过当前最好方法10%以上,验证了本文方法的有效性。 | 戴玉超 张静 Fatih PORIKLI 何明一 | 2018 | 测绘学报2018，47，6： | 16 |
| 3 | Ultrasound guided percutaneous cholecystostomy in high-risk patients for surgical intervention显示文摘AIM: To assess the efficacy and safety of ultrasound guided percutaneous cholecystostomy (PC) in the treatment of acute cholecystitis in a well-defined high risk patients under general anesthesia. METHODS: The data of 27 consecutive patients who underwent percutaneous transhepatic cholecystostomy for the management of acute cholecystitis from January 1999 to June 2003 was retrospectively evaluated. All of the patients had both clinical and sonographic signs of acute cholecystitis and had comorbid diseases. RESULTS: Ultrasound revealed gallbladder stones in 25 patients and acalculous cholecystitis in two patients. Cholecystostomy catheters were removed 14-32 d (mean 23 d) after the procedure in cases where complete regression of all symptoms was achieved. There were statistically significant reductions in leukocytosis, (13.7 × 103 ± 1.3 × 103 μg/L vs 13 × 103 ± 1 × 103 μg/L, P < 0.05 for 24 h after PC; 13.7 × 103 ± 1.3 × 103 μg/L vs 8.3 × 103 ± 1.2 × 103 μg/L, P < 0.0001 for 72 h after PC), C -reactive protein (51.2 ± 18.5 mg/L vs 27.3 ± 10.4 mg/L, P < 0.05 for 24 h after PC; 51.2 ± 18.5 mg/L vs 5.4 ± 1.5 mg/L, P < 0.0001 for 72 h after PC), and fever (38 ± 0.35℃ vs 37.3 ± 0.32℃, P < 0.05 for 24 h after PC; 38 ± 0.35℃ vs 36.9 ± 0.15℃, P < 0.0001 for 72 h after PC). Sphincterotomy and stone extraction was performed successfully with endoscopic retrograde cholangio-pancreatography (ERCP) in three patients. After cholecystostomy, 5 (18%) patients underwent delayed cholecystectomy without any complications. Three out of 22 patients were admitted with recurrent acute cholecystitis during the follow-up and recoveredwith medical treatment. Catheter dislodgement occurred in three patients spontaneously, and two of them were managed by reinsertion of the catheter. CONCLUSION: As an alternative to surgery, percutan- eous cholecystostomy seems to be a safe method in critically ill patients with acute cholecystitis and can be performed with low mortality and morbidity. Delayed cholecystectomy and ERCP, if needed, can be performed after the acute period has been resolved by percutaneous cholecystostomy. | Huseyin Bakkaloglu Hakan Yanar Recep Guloglu Korhan Taviloglu Fatih Tunca Murat Aksoy Cemalettin Ertekin Arzu Poyanli | 2006 | World Journal of Gastroenterology2006，12，44： | 15 |
| 4 | Salient Object Detection from Multi-spectral Remote Sensing Images with Deep Residual Network显示文摘alient object detection aims at identifying the visually interesting object regions that are consistent with human perception. Multispectral remote sensing images provide rich radiometric information in revealing the physical properties of the observed objects, which leads to great potential to perform salient object detection for remote sensing images. Conventional salient object detection methods often employ handcrafted features to predict saliency by evaluating the pixel-wise or superpixel-wise contrast. With the recent use of deep learning framework, in particular, fully convolutional neural networks, there has been profound progress in visual saliency detection. However, this success has not been extended to multispectral remote sensing images, and existing multispectral salient object detection methods are still mainly based on handcrafted features, essentially due to the difficulties in image acquisition and labeling. In this paper, we propose a novel deep residual network based on a top-down model, which is trained in an end-to-end manner to tackle the above issues in multispectral salient object detection. Our model effectively exploits the saliency cues at different levels of the deep residual network. To overcome the limited availability of remote sensing images in training of our deep residual network, we also introduce a new spectral image reconstruction model that can generate multispectral images from RGB images. Our extensive experimental results using both multispectral and RGB salient object detection datasets demonstrate a significant performance improvement of more than 10% improvement compared with the state-of-the-art methods. | Yuchao DAI Jing ZHANG Mingyi HE Fatih PORIKLI Bowen LIU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 14 |
| 5 | Rare etiology of mechanical intestinal obstruction: Abdominal cocoon syndrome显示文摘Abdominal cocoon syndrome is a rare cause of intestinal obstruction with unknown etiology. Diagnosis of this syndrome, which can be summarized as the small intestine being surrounded by a fibrous capsule not containing the mesothelium, is difficult in the preoperative period. A 47-year-old male patient was referred to the emergency department with complaints of abdominal pain, nausea, and vomiting for two days. The abdominal computed tomography examination detected dilated small intestinal loops containing air-fluid levels clustered in the left upper quadrant of the abdomen and surrounded by a thick, saclike, contrast-enhanced membrane. During exploratory surgery, a capsular structure was identified in the upper left quadrant with a regular surface that was solid-fibrous in nature. Ab-dominal cocoon syndrome is a rarely seen condition, for which the preoperative diagnosis is difficult. The combination of physical examination and radiological signs, and the knowledge of 'recurrent characteristics of the complaints' that can be learned by a careful history, may be helpful in diagnosis. | Yener Uzunoglu Fatih Altintoprak Omer Yalkin Yasemin Gunduz Guner Cakmak Orhan V Ozkan Fehmi Celebi | 2014 | World Journal of Clinical Cases2014，2，11： | 13 |
| 6 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 7 | A fast and efficient coordinated vehicle-to-grid discharging control scheme for peak shaving in power distribution system显示文摘This study focuses on the potential role of plugin electric vehicles(PEVs) as a distributed energy storage unit to provide peak demand minimization in power distribution systems. Vehicle-to-grid(V2 G) power and currently available information transfer technology enables utility companies to use this stored energy. The V2 G process is first formulated as an optimal control problem.Then, a two-stage V2 G discharging control scheme is proposed. In the first stage, a desired level for peak shaving and duration for V2 G service are determined off-line based on forecasted loading profile and PEV mobility model. In the second stage, the discharging rates of PEVs are dynamically adjusted in real time by considering the actual grid load and the characteristics of PEVs connected to the grid. The optimal and proposed V2 G algorithms are tested using a real residential distribution transformer and PEV mobility data collected from field with different battery and charger ratings for heuristic user case scenarios. The peak shaving performance is assessed in terms of peak shaving index and peak load reduction. Proposed solution is shown to be competitive with the optimal solution while avoiding high computational loads. The impact of the V2 G management strategy on the system loading at night is also analyzed by implementing an off-line charging scheduling algorithm. | Nuh ERDOGAN Fatih ERDEN Mithat KISACIKOGLU | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，3： | 12 |
| 8 | Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic options显示文摘Retinopathy of prematurity (ROP), a retinal vascular disease of premature infants, continues to be a major cause of preventable childhood blindness all over the world. The incidence of ROP varies among countries, being influenced by the quality of the level of neonatal intensive care. Here, we discuss the potential treatments that are now available or will soon or probably be available for ROP. Although ablation of the avascular retina with laser photocoagulation remains the current gold standard and well established therapy for ROP, some new therapeutic options including angiostatic therapies are being explored based on our knowledge of the pathophysiology of the ROP and complications and efficacy of laser treatment. However, prevention of the development of severe ROP and screening for ROP seem to be the best strategy in avoiding visual impairment caused by ROP in premature infants. New therapeutic interventions including vascular endothelial growth factor antibody administration, gene therapy and supplemental therapies should be supported with evidence-based data for the treatment of ROP. | Fatih Mehmet Mutlu Umit Serdar Sarici | 2013 | International Journal of Ophthalmology(English edition)2013，6，2： | 11 |
| 9 | Planned second-look laparoscopy in the management of acute mesenteric ischemia显示文摘AIM: To investigate the role of second-look laparoscopy in patients with acute mesenteric ischemia (AMI).METHODS: Between January 2000 and November 2005, 71 patients were operated for the treatment of AMI. The indications for a second-look were low flow state, bowel resection and anastomosis or mesenteric thromboembolectomy performed during the first operation. Regardless of the clinical course of patients, the second-look laparoscopic examination was performed 72 h post-operatively at the bed side in the ICU or operating room.RESULTS: The average time of admission to the hospital after the initiation of symptoms was 3 d (range, 5 h-9 d). In 14 patients, laparotomy was performed. In 11 patients, small and/or large bowel necrosis was detected and initial resection and anastomosis were conducted. A low flow state was observed in two patients and superior mesenteric artery thromboembolectomy with small bowel resection was performed in one patient. In 13 patients, a second-look laparoscopic examination revealed normal bowel viability, but in one patient, intestinal necrosis was detected. In two of the patients, a third operation was necessary to correct anastomotic leakage. The overall complication rate was 42.8%, and in-hospital mortality rate was 57.1% (n = 6).CONCLUSION: Second-look laparoscopy is a minimally invasive, technically simple procedure that is performed for diagnostic as well as therapeutic purposes. The simplicity and ease of this method may encourage wider application to benefit more patients. However, the timing of a second-look procedure is unclear particularly in a patient with anastomosis. | Hakan Yanar Korhan Taviloglu Cemalettin Ertekin Beyza Ozcinar Fatih Yanar Recep Guloglu Mehmet Kurtoglu | 2007 | World Journal of Gastroenterology2007，13，24： | 11 |
| 10 | H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A retrospective study显示文摘AIM: To identify and evaluate the relative impact of H pylori infection and other risk factors on the occurrence of gastric ulcer (GU), duodenal ulcer (DU) and gastritis in Turkish patients. METHODS: A total of 4471 patients (48.3% female) out of 4863 attended the Samatya hospital in Istanbul (June 1999 - October 2003) were included. The records of H pylori status (CLO-test), endoscopic f indings of GU, DU and gastritis, personal habits (smoking, alcohol intake) and medication [non-steroidal anti-inflammatory drugs (NSAIDs), aspirin intake] were analyzed using multi-way frequency analysis. RESULTS: We have found that GU in the presence of H pylori had significant association with aspirin (P = 0.0001), alcohol (P = 0.0090) and NSAIDs (P = 0.0372). DU on the other hand had significant association with aspirin/ smoking/NSAIDs (P = 0.0259), aspirin/alcohol (P = 0.0002) and aspirin/smoking (P = 0.0233), also in the presence of H pylori. In the absence of H pylori GU had significant association with alcohol/NSAIDs (P = 0.0431), and NSAIDs (P = 0.0436). While DU in the absence of H pylori had significant association with smoking/alcohol/ NSAIDs (P = 0.0013), aspirin/NSAIDs (P = 0.0334), aspirin/alcohol (P = 0.0360). CONCLUSION: In the presence of H pylori, aspirin, alcohol and NSAIDs intake act as an independent risk factors that had an augmenting impact on the occurrence of GU and only together on the occurrence of DU in Turkish patients. | Barik A Salih M Fatih Abasiyanik Nizamettin Bayyurt Ersan Sander | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 11 | Moheli岛快速灭源灭疟法实施1年报告(英文)显示文摘【目的】探讨在Moheli岛实施快速灭源灭疟法(FEMSE)治疗疟疾的效果。【方法】采用FEMSE法制定统一的疟疾治疗方案,对疟原虫诊断阳性者,按Artequick-Primaquine(青蒿素-哌喹-伯氨喹)标准方案(2d为1疗程)给予治疗:成人首剂2片,24h后再服2片,1疗程总量4片。儿童带虫率<10%的地区全民服药1次;儿童带虫率≥10%的村进行两次全民服药,相隔42 d。主要观察服药率及人群带虫率。【结果】服药率:第1次全民服药人数合计32 519人(同期登记总人口数为37243人,367个6个月以内的婴儿未参与服药),服药率为88.2%;第2次全民服药人数合计35 370人(同期登记总人口数为37 112人,335个6个月以内的婴儿未参与服药),服药率为96.2%。人群带虫率:全民服药前人群带虫率为22.95%(281/1 224),全民服药后2个月带虫率降为1.41%(28/1 987),4个月带虫率降为0.33%(8/2 458),下降幅度为98.56%。【结论】全民服药后4个月人群带虫率从22.95%下降到0.33%,表明采用FEMSE法服用Artequick-Primaquine清除体内疟原虫能够在短时间内使人群带虫率迅速下降,且未见明显的不良反应。在巩固阶段若能有效地组织监督实施清除疟疾的计划,可使人群带虫率和发病率进一步下降。 | 李国桥 宋健平 邓长生 Moussa Mohamed Ahamada MSA Mliva Fatihou Oithik 陈沛泉 谈博 | 2010 | 广州中医药大学学报2010，27，1： | 10 |
| 12 | 帕罗西汀与达帕西汀的对比,治疗早泄的新的选择性5-羟色胺再摄取抑制剂显示文摘达帕西汀氢氯化物是一种选择性5-羟色胺再摄取抑制剂,也是第一种被批准可以按需服用治疗早泄的药物。本文目的为研究按需服用达帕西汀(30mg和H60mg)和每日服用帕罗西汀(20mg)对早泄的疗效。研究募集了150名患者进行了长达1个月的研究。患者被分成3组,每组50人。第一组按需服用达帕西汀30mg。第二组按需服用达帕西汀60mg。第三组每日服用帕罗西汀20mg。治疗结束后,我们的结果检测值相对于基准阴道内射精潜伏期(IELT)延长了。与基准IELT相比,帕罗西汀组、30mg达帕西汀组和60mg达帕西汀组的治疗后IELT分别延长了117%(P〈0.01),117%(P〈0.01)和170%(P〈0.01)。30mg达帕西汀组和帕罗西汀组的IELT增幅相同(P〉0.05),而60mg达帕西汀组的IELT增幅明显高于30mg达帕西汀组(P〈0.05和帕罗西汀组P〈0.01)。性交前1~3小时服用达帕西汀60mg是针对早泄的非常有效的治疗方法。然而,与当前普遍使用的帕罗西汀相比,达帕西汀30mg疗效并不显著。 | Abdulmuttalip Simsek Sinan Levent Kirecci Onur Kucuktopcu Faruk Ozgor Mehmet Fatih Akbulut Omer Sarilar Unsal Ozkuvanci Zafer Gokhan Gurbuz | 2014 | Asian Journal of Andrology2014，16，5： | 10 |
| 13 | Effect of Heat Treatment on Microstructure,Mechanical Properties and Fracture Behaviour of Ship and Dual Phase Steels显示文摘Grade A(GA)and high strength steel DH36 ship steels possessing different chemical compositions were used,and strength properties of GA steel and DH36 steel were compared.Additionally,4 types of dual phase(DP)steels with different martensite volume fractions(MVFs)were produced from GA steel by means of heat treatment and they were compared with other steels through conducting microstructure,microhardness,tensile and impact tests.The fracture surfaces of specimens(DH36,GA and DP steels)exposed to tensile and Charpy impact tests were investigated by scanning electron microscope.Furthermore,it was found that the specimens quenched from 800 and 900 ℃ had better strength than DH36 steel.The tensile test results indicated that the tensile strength of DP steel water quenched from 900 ℃ was 3 times that of GA steel and twice that of DH36 steel. | Fatih Hayat Hüseyin Uzun | 2011 | Journal of Iron and Steel Research(International)2011，18，8： | 9 |
| 14 | Examining the whole bowel, double balloon enteroscopy: Indications, diagnostic yield and complications显示文摘Double balloon enteroscopy(DBE) is an advanced type of endoscopic procedure which brings the advantage of reaching the whole small bowel using anterograde or the retrograde route. This procedure is both diagnostic and interventional for a variety of small intestinal diseases, such as vascular lesions, tumors, polyps and involvement of inflammatory bowel diseases.Main indication is the diagnosis and treatment of mid-gastrointestinal bleeding according to the recent published data all over the world. The complication rates seem to be higher than conventional procedures but growing experience is lowering them and improving the procedure to be safe and well tolerated. This review is about the technique, indications, diagnostic importance and complications of DBE according to the literature growing since 2001. | Fatih Saygili Saba Mukaddes Saygili Erkin Oztas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 9 |
| 15 | Association of CagA and VacA presence with ulcer and non-ulcer dyspepsia in a Turkish population显示文摘AIM: The mostly known genotypic virulence features, of H. pyloriare cytotoxin associated gene A (ragA) and Vacuolating cytotoxin gene A (VacA). We investigated the association of these major virulence factors with ulcer and non-ulcer dyspepsia in our region.METHODS: One hundred and forty two dyspeptic patients were studied (average age 44.8±15.9 years, range 15-87years, 64 males and 78 females). Antral and corpus biopsies were taken for detecting and genotyping of H. pylori. 107patients who were H. pylori positive by histological assessment were divided into three groups according to endoscopic findings: Duodenal ulcer (DU), gastric ulcer (GU)and non-ulcer dyspepsia (NUD). The polymerase chain reaction (PCR) was used to detect CagA and VacA genes of H.pylori using specific primers.RESULTS: H.pyloriwas isolated from 75.4 % (107/142) of the patients. Of the 107 patients, 66 (61.7 %) were cagApositive and 82 (76.6 %) were Vacl-positive. CagA gene was positively associated with DU and GU (P<0.01, P<0.02),but not with NUD (P>0.05). Although VacA positivity in ulcer patients was higher than that in NUD group, the difference was not statistically significant (P>0.05).CONCLUSION: There is a significantly positive association between CagA genes and DU and GU. The presence of VacA is not a predictive marker for DU, GU, and NUD in our patients. | Kantarceken Bulent Aladag Murat Atik Esin Koksal Fatih Harputluoglu MMMurat Harputluoglu Hakan Karincaoglu Melih Ares Mehmet Yildirim Bulent Hilmioglu Fatih | 2003 | World Journal of Gastroenterology2003，9，7： | 8 |
| 16 | Catalytic performance of Cu-and Zr-modified beta zeolite catalysts in the methylation of 2-methylnaphthalene显示文摘2,6-Dimethylnaphthalene(2,6-DMN) is a commercially important chemical for the production of polyethylenenaphthalate and polybutylene naphthalate. However, its complex synthesis procedure and high production cost significantly reduce the use of 2,6-DMN. In this study, the synthesis of 2,6-DMN was investigated with methylation of 2-methylnaphthalene(2-MN) over metal-loaded beta zeolite catalysts including beta zeolite, Cu-impregnated beta zeolite and Zr-impregnated beta zeolite. The experiments were performed in a fixed-bed reactor at atmospheric pressure under a nitrogen atmosphere. The reactor was operated at a temperature range of 400–500 °C and varying weight hourly space velocity between 1 and 3 h^(-1).The results demonstrated that 2,6-DMN can be synthesized by methylation of 2-MN over beta type zeolite catalysts.Besides 2,6-DMN, the product stream also contained other DMN isomers such as 2,7-DMN, 1,3-DMN, 1,2-DMN and 2,3-DMN. The activity and selectivity of beta zeolite catalyst were remarkably enhanced by Zr impregnation, whereas Cu modification of beta zeolite catalyst had an insignificant effect on its selectivity. The highest conversion of 2-MN reached81%, the highest ratio of 2,6-DMN/2,7-DMN reached 2.6 and the highest selectivity of 2,6-DMN was found to be 20% by using Zr-modified beta zeolite catalyst. | Fatih Gülec Farooq Sher Ali Karaduman | 2019 | Petroleum Science2019，16，1： | 8 |
| 17 | Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells:An experimental study显示文摘AIM:To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat model.· METHODS:Forty female,Wistar rats were randomized in 4 groups in the study.Subcutaneous ERT (17β-estradiol,10g/kg/day) was administered to the first group without ovariectomy and to the second group with ovariectomy for three months.Third group had only ovariectomy and fourth group had sham operation.All rats were sacrificed in estrous cycles determined by vaginal smear test and their right eyes were enucleated at the end of the third month.Enucleated eyes were analyzed by immunohistochemical method for expressions of caspase-3,bcl-2,VEGF and TUNEL assay.· RESULTS:Caspase-3 expression of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.005),and group 2 (P =0.007).TUNEL score of conjunctival epithelium was significantly higher in group 3 than group 1 (P =0.006).TUNEL score of corneal epithelium was significantly higher in group 3 than group 2 (P =0.012),and group 4 (P =0.002).There was no significant difference between groups in that bcl-2 and VEGF expressions.· CONCLUSION:We determined increased apoptosis in ocular surface epithelial cells in ovariectomized rats.ERT and endogen estrogen decreased the apoptosis,and did not result in difference in VEGF expression between the groups.Estrogen may be beneficial for the treatment of apoptosis-mediated ocular surface disorders such as dry eye.Further studies are needed on this subject for a better understanding of the role of estrogen and to provide a new insight for treatment and prevention of apoptosis-mediated ocular surface disorders. | Fatih zcura Sema Oru Dndar Emel Dikicioglu etin Nahit Beder Mehmet Dndar | 2012 | International Journal of Ophthalmology(English edition)2012，5，1： | 7 |
| 18 | Determining Crop and Pan Coefficients for Cauliflower and Red Cabbage Crops Under Cool Season Semiarid Climatic Conditions显示文摘The aim of this study was to estimate the evapotranspiration of cauliflower and red cabbage crops grown under cool season semiarid climatic conditions from Class A pan evaporation. Actual evapotranspiration (ETc) of cauliflower and red cabbage crops was calculated according to the water balance approach. Reference evapotranspiration (ETo) was calculated with FAO Penman-Monteith equation. Pan evaporation (Epan) was measured by using Class A pan. Seasonal ETc was determined as 475 mm for cauliflower and 556 mm for red cabbage. Seasonal pan coefficient (kp = ETo/Epan) was determined as 0.82, and the seasonal crop coefficient (kc = ETc/ETo) was determined as 0.84 for cauliflower and 0.83 for red cabbage. So the evapotranspiration of cauliflower and red cabbage crops was estimated as 70% Class A pan evaporation. | Ustun Sahin Yasemin Kuslu Talip Tunc Fatih Mehmet Kiziloglu | 2009 | Agricultural Sciences in China2009，8，2： | 7 |
| 19 | Comparing Properties of Adhesive Bonding,Resistance Spot Welding,and Adhesive Weld Bonding of Coated and Uncoated DP 600 Steel显示文摘Zinc coated dual phase 600 steel(DP 600 grade)was investigated,utilisation of which has gradually increased with each passing day in the automotive industry.The adhesive bonding(AB),resistance spot welding(RSW),and adhesive weld bonding(AWB)joints of the zinc coated DP 600 steel were investigated.Additionally,the zinc coating was removed using HCL acid in order to investigate the effect of the coating.The microstructure,tensile shear strengths,and fracture properties of adhesive bonding(AB),resistance spot welding(RSW),and adhesive weld bonding(AWB)joints of the coated and uncoated DP 600 steel were compared.In addition,a mechanical-electrical-thermal coupled model in a finite element analysis environment was utilised.The thermal profile phenomenon was calculated by simulating this process.The results of the tensile shear test indicated that the tensile load bearing capacity(TLBC)values of the coated specimens among the three welding methods were higher than those of the uncoated specimens.Additionally,the tensile strength of the AWB joints of the coated and uncoated specimens was higher than that of the AB and RSW joints.It was determined that the fracture behaviours and the deformation caused were different for the three welding methods. | Fatih Hayat | 2011 | Journal of Iron and Steel Research(International)2011，18，9： | 7 |
| 20 | Intestinal obstruction due to phytobezoars: An update显示文摘The term bezoar refers to an intraluminal mass in the gastrointestinal system caused by the accumulation of indigestible ingested materials, such as vegetables, fruits, and hair. Bezoars are responsible for 0.4%-4% of cases of mechanical intestinal obstruction. The clinical findings of bezoar-induced ileus do not differ from those of mechanical intestinal obstruction due to other causes. The appearance and localization of bezoars can be established with various imaging methods. Treatment of choice depends on the localization of the bezoar which makes the clinical findings. | Enis Dikicier Fatih Altintoprak Orhan Veli Ozkan Orhan Yagmurkaya Mustafa Yener Uzunoglu | 2015 | World Journal of Clinical Cases2015，3，8： | 7 |
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