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| 1 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 2 | Frequency and prognostic role of mucosal healing in patients with Crohn's disease and ulcerative colitis after one-year of biological therapy显示文摘AIM:To assess the endoscopic activity before and after a one-year period of biological therapy and to evaluate the frequency of relapses and need for retreatment after stopping the biologicals in patients with Crohn’s disease(CD)and ulcerative colitis(UC).METHODS:The data from 41 patients with CD and 22 patients with UC were assessed.Twenty-four CD patients received infliximab,and 17 received adalimumab.The endoscopic severity of CD was quantified with the simplified endoscopic activity score for Crohn’s disease in CD and with the Mayo endoscopic subscore in UC.RESULTS:Mucosal healing was achieved in 23 CD and7 UC patients.Biological therapy had to be restarted in78%of patients achieving complete mucosal healing with CD and in 100%of patients with UC.Neither clinical remission nor mucosal healing was associated with the time to restarting the biological therapy in either CD or UC.CONCLUSION:Mucosal healing did not predict sustained clinical remission in patients in whom the biological therapies had been stopped. | Klaudia Farkas Péter László Lakatos Mónika Szcs va Pallagi-Kunstár Anita Bálint Ferenc Nagy Zoltán Szepes Noémi Vass Lajos S Kiss Tibor Wittmann Tamás Molnár | 2014 | World Journal of Gastroenterology2014，20，11： | 2 |
| 3 | Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease显示文摘AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC) (n = 15) patients with a known previous (AZA) hypersensitivity reaction were studied prospectively. The 6-MP doses were gradually increased from 0.5 up to 1.0-1.5 mg/kg per day. Clinical activity indicies (CDAI/CAI), laboratory variables and daily doses of oral 5-ASA, corticosteroids, and 6-MP were assessed before and in the first, sixth and twelfth months of treatment. RESULTS: In 9 patients, 6-MP was withdrawn in the first 2 wk due to an early hypersensitivity reaction. Medication was ineffective within 6 mo in 6 CD patients, and myelotoxic reaction was observed in two. Data were evaluated at the end of the sixth month in 12 (8 UC, 4 CD) patients, and after the first year in 9 (6 UC, 3 CD) patients. CDAI decreased transiently at the end of the sixth month, but no significant changes were observed in the CDAI or the CAI values at the end of the year. Leukocyte counts (P = 0.01), CRP (P = 0.02), and serum iron (P = 0.05) values indicated decreased inflammatory reactions, especially in the UC patients at the end of the year, making the possibility to taper oral steroid doses. CONCLUSION: About one-third of the previously AZA- intolerant patients showed adverse effects on taking 6MP. In our series, 20 patients tolerated 6MP, but it was ineffective in 8 CD cases, and valuable mainly in ulcerative colitis patients. | Ferenc Nagy Tamás Molnár Zoltán Szepes Klaudia Farkas Tibor Nyári János Lonovics | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 4 | NR2B subunit selective NMDA antagonists inhibit neurotoxic effect of alcohol - withdrawal in primary cultures of rat cortical neurones 显示文摘 | Nagy J Horvath C Farkas S | 2004 | Neurochem Int2004，44，1： | 1 |
| 5 | Reduction of endogenous transforming growth factors β prevents ontogenetic neuron death显示文摘 | Krieglstein K Richter S Farkas L | 2000 | Nat Neurosci2000，3，11： | 1 |
| 6 | Competition in patchy environment with cross diffusion显示文摘 | ALY S FARKAS M | 2004 | Nonlinear Analysis:Real World Applications2004，5，4： | 1 |
| 7 | Predictive validity of end- points used in electrophysiological modelling of migraine in the tri- geminovascular system显示文摘 | Farkas B Kardos P Orosz S | 2015 | Brain Res2015，1625，： | 1 |
| 8 | Noroviruses bind to human ABO,Lewis,and secretor histo-blood group antigens:identification of 4 distinct strain-specific patterns显示文摘 | Huang P Farkas T Marionneau S | 2003 | J Infect Dis2003，188，1： | 1 |
| 9 | Effect of thermal treatment on moisture transport during steam cooking of skipjack tuna (Katsuwonas pelamis)显示文摘 | BELL J W FARKAS B E HALE S A | 2001 | J Food Scie2001，66，2： | 1 |
| 10 | Effects of common laser treatments on hyaluronic acid fillers in a porcine model 显示文摘 | Farkas JP Richardson JA Brown S | 2008 | Aesthet Surg2008，28，5： | 1 |
| 11 | Competition in patchy environment with cross diffusion 显示文摘 | Aly S Farkas M | 2004 | Nonlinear Analysis: Real World Applications2004，5，4： | 1 |
| 12 | Improvement of Functionality and Reliability by Inductive HTS Fault Current Limiter Units显示文摘 | Gyore A Semperger S Farkas L | 2005 | IEEE Transactions on Applied Superconductivity2005，15，2： | 1 |
| 13 | Dislocation activity and nano-void formation near crack tips in nanocrystalline ni显示文摘 | FARKAS D VAN P S DERLET P M | 2005 | Acta Materialia2005，53，： | 1 |
| 14 | Effects of cyclooxygenase (COX) inhibition on memory impairment and hippocampal damage in the early period of cerebral hypoperfusion in rats 显示文摘 | Institoris A Farkas E Berczi S | 2007 | Eur J Pharmacol2007，574，1： | 1 |
| 15 | Simultaneous, live imaging of cortical spreading depres- sion and associated cerebral blood flow changes, by combining voltage-sensitive dye and laser speckle contrast methods 显示文摘 | Obrenovitch TP Chen S Farkas E | 2009 | Neuroimage2009，45，： | 1 |
| 16 | Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion显示文摘 | Eszter Farkas ádám Institóris Ferenc Domoki András Mihály Paul G.M Luiten Ferenc Bari | 2004 | Brain Research2004，，2： | 1 |
| 17 | Calcium isotopic fractionation between clinopy- roxene and orthopyroxene from mantle perido- tites显示文摘 | HUANG S C FARKAS J JACOBSEN S B | 2010 | Earth & Planetary Science Letters2010，292，34： | 1 |
| 18 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 19 | Noroviruses bind to human ABO, Lewis, and secretor histo-blood group antigenss identification of 4 distinct strain-specific patterns 显示文摘 | Huang P Farkas T Marionneau S | 2003 | J Infect Dis2003，188，1： | 1 |
| 20 | Stable calcium isotopic compositions of Hawaiian shield lavas: Evidence for recycling of ancient marine carbonates into the mantle显示文摘 | HUANG S C FARKAS J JACOBSEN S B | 2011 | Geochim Cosmochim Acta2011，75，17： | 1 |
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