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| 1 | Recent advances in bone regeneration using adult stem cells显示文摘Bone is a highly vascularized tissue reliant on the close spatial and temporal association between bloodvessels and bone cells. Therefore, cells that participate in vasculogenesis and osteogenesis play a pivotal role in bone formation during prenatal and postnatal periods. Nevertheless, spontaneous healing of bone fracture is occasionally impaired due to insufficient blood and cellular supply to the site of injury. In these cases, bone regeneration process is interrupted, which might result in delayed union or even nonunion of the fracture. Nonunion fracture is difficult to treat and have a high financial impact. In the last decade, numerous technological advancements in bone tissue engineering and cell-therapy opened new horizon in the field of bone regeneration. This review starts with presentation of the biological processes involved in bone development, bone remodeling, fracture healing process and the microenvironment at bone healing sites. Then, we discuss the rationale for using adult stem cells and listed the characteristics of the available cells for bone regeneration. The mechanism of action and epigenetic regulations for osteogenic differentiation are also described. Finally, we review the literature for translational and clinical trials that investigated the use of adult stem cells(mesenchymal stem cells, endothelial progenitor cells and CD34+ blood progenitors) for bone regeneration. | Hadar Zigdon-Giladi Utai Rudich Gal Michaeli Geller Ayelet Evron | 2015 | World Journal of Stem Cells2015，7，3： | 9 |
| 2 | DNA methylation of RASSF1A, HIN-I, RAR beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma显示文摘 | Fackler M J McVeigh M Evron E | 2003 | Int J Cancer2003，107，6： | 1 |
| 3 | Remifentanil: a novel systemic analgesic for labor pain显示文摘 | EVRON S GLEZERMAN M SADAN O | 2005 | Anesth Analg2005，100，1： | 1 |
| 4 | Predistention of the epidural space before catheter insertion reduces the incidence of intravascular epidural catheter insertion显示文摘 | EVRON S GLADKOV V SESSLER D I | 2007 | Anesth and Analg2007，105，2： | 1 |
| 5 | Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specifit promoter methylation显示文摘 | Loeb DM Evron E Patel CB | 2001 | Cancer Res2001，61，3： | 1 |
| 6 | Point mutation and homozygous de-letion of PTEN/MMAC1 in primary bladder cancers显示文摘 | Evron E Okami K | 1998 | Oncogene1998，16，24： | 1 |
| 7 | Nasal versus oral fiberoptic intubation via a cuffed oropharyngeal airway ( COPA ) during spontaneous ventilation 显示文摘 | Ezri T Szmuk P Evron S | 2004 | J Clin Anesth2004，16，7： | 1 |
| 8 | 'An ounce of prevention is worth a pound of cure': the case for and against GnRH -agonist for fertility preservation显示文摘 | Blumenfeld Z Katz G Evron A | 2014 | Ann Oncol2014，25，9： | 1 |
| 9 | Wilms' tumor suppressor gene(WT1) is expressed in primary breast tumors despite tumor-specif-ic promoter methylation 显示文摘 | Loeb DM Evron E Patel CB | 2001 | Cancer Res2001，61，3： | 1 |
| 10 | A brief history of tracheostomy and tracheal intubation, from the Bronze Age to the Space Age显示文摘 | Peter Szmuk Tiberiu Ezri Shmuel Evron Yehudah Roth Jeffrey Katz | 2008 | Intensive Care Medicine2008，，2： | 1 |
| 11 | Synaptogenesis and myopathy under acetylcholinesterase overexpression显示文摘 | Lev-Lehman E Evron T Broide RS | 2000 | J Mol Neurosck2000，14，12： | 1 |
| 12 | Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR 显示文摘 | Evron E Dooley WC Umbricht CB | 2001 | Lancet2001，357，9265： | 1 |
| 13 | Imbalance of immune responses in patientswith chronic and widespread fungal skin infection显示文摘 | Leibovici V Evron R Axelrod O | 1995 | Clin Exp Dermatol1995，20，5： | 1 |
| 14 | Detection of breast cancer cells in ductal lavage fluid by methylation-specific PCR显示文摘 | Evron E Dooley WC Umbricht CB | 2001 | Lancet2001，357，9265： | 1 |
| 15 | Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers显示文摘 | Evron E Okami K | 1998 | Oncogene1998，16，24： | 1 |
| 16 | Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast显示文摘 | Kominsky SL Argani P Korz D Evron E Raman V Garrett E | 2003 | Oncogene2003，22，13： | 1 |
| 17 | Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers显示文摘 | Cairns P Evron E Okami K | 1998 | Oncogene1998，16，24： | 1 |
| 18 | Remifentanil:A novel systemic analgesic for labor pain显示文摘 | Evron S Glezerman M Sadan O | 2005 | Anesth Analg2005，100，： | 1 |
| 19 | Tissue response to sur- gical energy devices 显示文摘 | Courtney KP Gregory WH Evron D | 2008 | Urology2008，71，4： | 1 |
| 20 | Severe peripheral arteriospasm following oxytocin administration显示文摘 | Evron S Ariely S Agasi M | 1986 | Am Obstet Gynecol1986，155，： | 1 |
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