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| 1 | Diagnostic non-invasive model of large risky esophageal varices in cirrhotic hepatitis C virus patients显示文摘AIM To build a diagnostic non-invasive model for screening of large varices in cirrhotic hepatitis C virus(HCV) patients. METHODS This study was conducted on 124 post-HCV cirrhotic patients presenting to the clinics of the Endemic Medicine Department at Mansoura University Hospital for evaluation before HCV antiviral therapy: 78 were Child A and 46 were Child B(score ≤ 8). Inclusion criteria for patients enrolled in this study was presence of cirrhotic HCV(diagnosed by either biopsy or fulfillment of clinical basis). Exclusion criteria consisted of patients with other etiologies of liver cirrhosis, e.g., hepatitis B virus and patients with high MELD score on transplant list. All patients were subjected to full medical record, full basic investigations, endoscopy, and computed tomography(CT), and then divided into groups with no varices, small varices, or large risky varices. In addition, values of Fibrosis-4 score(FIB-4), aminotransferase-to-platelet ratio index(APRI), and platelet count/splenic diameter ratio(PC/SD) were also calculated.RESULTS Detection of large varies is a multi-factorial process, affected by many variables. Choosing binary logistic regression, dependent factors were either large or small varices while independent factors included CT variables such coronary vein diameter, portal vein(PV) diameter, lieno-renal shunt and other laboratory noninvasive variables namely FIB-4, APRI, and platelet count/splenic diameter. Receiver operating characteristic(ROC) curve was plotted to determine the accuracy of non-invasive parameters for predicting the presence of large esophageal varices and the area under the ROC curve for each one of these parameters was obtained. A model was established and the best model for prediction of large risky esophageal varices used both PC/SD and PV diameter(75% accuracy), while the logistic model equation was shown to be(PV diameter ×-0.256) plus(PC/SD ×-0.006) plus(8.155). Values nearing 2 or more denote large varices.CONCLUSION This model equation has 86.9% sensitivity and 57.1% specificity, and would be of clinical applicability with 75% accuracy. | Hatem Elalfy Walid Elsherbiny Ashraf Abdel Rahman Dina Elhammady Shaker Wagih Shaltout Ayman Z Elsamanoudy Bassem El Deek | 2016 | World Journal of Hepatology2016，8，24： | 5 |
| 2 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 3 | An irmnunogenicity stud)' of a newl~ fusion protein Can-FnBP vaccinated against Staphylococcus aureus irffeetions in a mice model 显示文摘 | ZHOU H XIONG Z Y ZHENG Y X el al | 2006 | Vaccine2006，24，： | 1 |
| 4 | A fuzzy cluste-ring-based niching approach to multimodal function optimization显示文摘 | El IMRANI A BOUROUMI A El ABIDINE Z H | 2000 | Journal of Cognitive System Research2000，1，2： | 1 |
| 5 | Fusion cross-sections for inertial fusion energy 显示文摘 | Li X Z Liu B Chen S el at | 2004 | Laser and Particle Beam2004，22，： | 1 |
| 6 | Fecal Incontinence in Hospitalized Patients Who Are Aeutely Ill显示文摘 | Bliss D Z Johnson S Savik K el al | 2000 | Nurs Res2000，49，2： | 1 |
| 7 | Single-center review of fluoroscopy-guided percutaneous nephrostomy performed by uro- logic surgeons 显示文摘 | RANA AM ZAID1 Z EL -KHALID S | 2007 | J Endourol2007，21，： | 1 |
| 8 | A comparative biomechanical investigation of anterior lumbar interbody cages:central and bilateral approaches显示文摘 | Hoffer Z Nydegger T el al | 2000 | J Bone Joint Surg Am2000，82，3： | 1 |
| 9 | Magnetic properties improvement in Fe3O4 nanoparticles 显示文摘 | WANG J ZHANG K PENG Z M el al | 2004 | Journal of Crystal Growth2004，266，： | 1 |
| 10 | Na- tion-wide analysis of outcomes of bowel preparation in colon- surgery显示文摘 | Moghadamyeghaneh Z Hanna MH Carmichael JC et el | 2015 | J Am Coil Surg2015，220，5： | 1 |
| 11 | Single-center review of fluoroscopy-guided percutaneous nephrostomy performed by urologic surgeons 显示文摘 | RANA AM ZAIDI Z EL KHALID S | 2007 | J Endourol2007，21，7： | 1 |
| 12 | 显示文摘 | Luboshitzky R Lavie L Shen - Orr Z el al | 2005 | Obes Res2005，13，4： | 1 |
| 13 | Laparoscopic splenectomy and azygoportal disconnection for bleeding varices with hypersplenism 显示文摘 | Wang Y D Ye H Ye Z Y el al | 2008 | J Laparoendosc Adv Surg Tech A2008，18，： | 1 |
| 14 | Exploring women's paychoneuroendocrine responses to cancer threat:insights from a computer-based guided imngery tesk显示文摘 | Ma Z Faber A Dubé L et el | 2007 | Can J Nurs Res2007，39，1： | 1 |
| 15 | Immunohistochemical profiling of Wnt,NF-κB,Stat3 and Notch signaling in human epidermal tumors显示文摘 | Liu Z Li Y Kong Q el al | 2008 | J Dermatol Sci2008，52，2： | 1 |
| 16 | Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: pharmacoki- netics and anti-tumor effects 显示文摘 | LI Y P PEI Y Y ZHOU Z H el al | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 17 | Microstructure and meechanical property of stripin Fe- 23 Mn- 3Si- 3 AI TWIP steed by twinroll eating 显示文摘 | Wang S H I iu Z Y Zhang w N el al | 2009 | ISlj Int2009，49，： | 1 |
| 18 | T-cell metabolism in autoimmune disease 显示文摘 | Yang Z Matteson EL Goronzy JJ | 2015 | Arthritis Res Ther2015，17，： | 1 |
| 19 | The Arabidopsis phytochrome B gene influcences growth of apple rootstock M26显示文摘 | Holefors A Xue Z T Zhu L H el al | 2000 | Plant Cell Rep2000，19，： | 1 |
| 20 | Update on diabetic neuropat hy 显示文摘 | Simmons Z Feldman EL | 2002 | Curr Opin Neurol2002，15，5： | 1 |
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