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| 1 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 2 | Matrix Metalloproteinases and Their Role in Pancreatic Cancer:a Review of Preclinical Studies and Clinical Trials显示文摘 | Bloomston M Zervos EE Rosemurgy AS 2nd | 2002 | Ann Surg Oncol2002，9，7： | 1 |
| 3 | Protective effect of green tea polyphenlo ( - ) epigallocatechin - 3 - gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates显示文摘 | L EE S R M KJ SUH S I | 2003 | J Phytother Res2003，17，3： | 1 |
| 4 | Liver transplantasion in pations with non- biliary cirrhosis:prognostic valuc of preoperative factors显示文摘 | Gonzale EE Rimola A Navasa M ct al | 1998 | J Hepatol1998，28，： | 1 |
| 5 | Single access site laparoscopic radical nephrectomy: initial clinical experience显示文摘 | PONSKY LE CHERULLO EE SAWYER M | 2008 | J Endourol2008，22，： | 1 |
| 6 | Development and regeneration of the nervous system: a role for neurosteroids 显示文摘 | Schumacher M Robel P Baulieu EE | 1996 | Dev Neurosci1996，18，12： | 1 |
| 7 | Neurosteroids with spercial reference to the effect of progesterone on mylination in peripberal nerves 显示文摘 | Baulieu EE Schumacher M | 1997 | Mult Scler1997，3，： | 1 |
| 8 | Honey thermal treatment effects on hydroxymethylfurfural content 显示文摘 | Tosi E Ciappini M E' EE | 2002 | Food Chem2002，，77： | 1 |
| 9 | Differential sensitivityof thick and thin fibers to HIV and therapy-induced neuropathy显示文摘 | Kokotis P Schmelz M Skopelitis EE | 2007 | Auton Neurosci2007，136，12： | 1 |
| 10 | Esophageal variceal hemorrhage presenting as sudden death in outpatients 显示文摘 | Tsokos M Turk EE | 2002 | Arch Pathol Lab Med2002，126，10： | 1 |
| 11 | Addition of Matrix Metalloproteinase Inhibition to Conventional Cytotoxic Therapy Reduces Tumor Implantation and Prolongs Survival in a Murine Model of Human Pancreatic Cancer 显示文摘 | Hag M Shafii A Zervos EE | 2000 | Cancer Res2000，60，12： | 1 |
| 12 | Sequence and localization of the mouse sperm autoantigenic protein, Sp17 显示文摘 | Kong M Richardson RT Widgren EE | 1995 | Biol Reprod1995，53，3： | 1 |
| 13 | Osseous Reconstruction Using a Membrane Barrier Following Marginal Mandibulectomy:An Animal Pilot Study显示文摘 | Peled M Machtei EE Rachmiel A | 2007 | J Periodontol2007，73，12： | 1 |
| 14 | Organ injury scaling,Ⅱ:Pancreas,duodenum,small bowel,colon,and retum显示文摘 | Moore EE Cogbill TH Malangoni M A | 1990 | J Trauma1990，30，11： | 1 |
| 15 | Morbidity and mor- tality rates in elderly patients undergoing percutaneous coronary transluminal angioplasty 显示文摘 | Lindsay J Jr Reddy ~M Pinnow EE | 1994 | Am Heart J1994，128，： | 1 |
| 16 | The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers显示文摘 | Noel EE Yeste-Velasco M Mao X | 2010 | Am J Pathol2010，176，6： | 1 |
| 17 | Hyperhomocystein-emia,folateo and B12 vitamin in Iranian patients with acute is-chemic stroke显示文摘 | Omrani HQ Shandiz EE Qabai M | 2011 | ARYA Atheroscler2011，7，3： | 1 |
| 18 | Prognostic factor and life expectancy of patients with acquired immunodeficiency syndrom and Pneumocystis carinii Pneumonia显示文摘 | Brenner M Ognibene OP Lake EE | 1987 | Am Rev Respir Dis1987，136，： | 1 |
| 19 | Unconstrained stereoscopic matching of lines 显示文摘 | Raymond van Ee Schora Clifton M | 2000 | Vision Research (S0042-6989)2000，40，2： | 1 |
| 20 | The importance of central compartment elective Lymph node excision in the staging and treatment of papillary thyroid cancer显示文摘 | Shindo M Wu JC Park EE | 2006 | Arch Otolaryngol Head Neck Surg2006，132，6： | 1 |
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