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| 1 | 欧洲血管外科学会指南:第二部分——颈动脉狭窄患者的诊断和检查显示文摘在此,我们呈献颈动脉狭窄患者脑血管事件二级预防的欧洲血管外科学会指南,包括降脂治疗、抗血小板治疗以及其他危险因素控制。这些推荐均基于现有的临床试验证据。对颈动脉病患者需要采取积极的预防性治疗。我们还讨论了颈动脉狭窄的诊断和分级。 | Christos D. Liapis Sir Peter F. Bell Dimitri P. Mikhailidis Juharli Sivenius Andrew Nicolaides Jose Femandes e Fernandes Giorgio Biasi Ears Norgrer 赵颖(译) 谭泽锋(译) 徐安定(译) | 2011 | 国际脑血管病杂志2011,19,7: | 9 |
| 2 | 虚拟制造环境中虚拟手的行为构造显示文摘为了实现虚拟制造环境中智能高效的虚拟手,改善目前主流的依赖对用户手抓握动作跟踪的状况,提出一种适用于虚拟制造环境的虚拟手自主行为构造方法.通过在虚拟手结构模型上增加感知环设计,构建虚拟手的感知能力;结合文中提出的虚拟手三阶段感知算法实现虚拟手的自适应行为机制,极大地减轻了操作者的认知和操作负载;通过构造虚拟手手势集和手势状态转换模型,实现了虚拟手在复杂零件表面的连续抓握操作.文中还重点研究了复杂零件表面虚拟手的连续抓握的行为机制和相关算法.实验结果表明,文中的虚拟手具有很好的几何真实感和行为真实感;提出的方法具有良好的可用性、可靠性和实时性. | 蔡娴娟 程成 Alhazmi Marwah Mostafa Hamdy Salem MongHeng Ear | 2015 | 计算机辅助设计与图形学学报2015,27,3: | 8 |
| 3 | A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure显示文摘5q-syndrome is a distinct form of myelodysplastic syndrome(MDS) where a deletion on chromosome 5 is the underlying cause.MDS is characterized by bone marrow failures,including macrocytic anemia.Genetic mapping and studies using various models support the notion that ribosomal protein S14(RPS14) is the candidate gene for the erythroid failure.Targeted disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal proteins.However,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment option.To better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 gene.This model mirrors the anemic phenotype seen in 5q-syndrome.Moreover,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes p53-dependent.Finally,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype. | Jason Ear Jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin | 2016 | Journal of Genetics and Genomics2016,43,5: | 5 |
| 4 | RNA methylation regulates hematopoietic stem and progenitor cell development显示文摘Methylation of adenosine base on the nitrogen-6 position(N6-methyladenosine,m^6A)is the most common and abundant modification on mRNA transcripts.This post-transcriptional modification was first described in the 1970s in hepatoma cells(Desrosiers et al.,1974).Since its discovery,m^6A has been found to occur on many prokaryotic,eukaryotic,and viral RNA | Jason Ear Shuo Lin | 2017 | Journal of Genetics and Genomics2017,44,10: | 3 |
| 5 | Porous poly (L-lactide)films obtained by immersion precipitation process: morphology,Phase separation and culture of VERO cell 显示文摘 | Zoppi RA Ciontant S Duek EAR | 1999 | Polymer1999,40,: | 1 |
| 6 | Helical CT Pneumocolon to Assess Colonic Tumor:Radiologic-pathologic Correlation显示文摘 | Harvey CJ Amin Z Eare CM | 1998 | AJR1998,170,6: | 1 |
| 7 | Effect of white-water contamination on newsprint properties显示文摘 | earing J T Barbe M C Ouchi M D | 1985 | Journal of Pulp and Paper Science1985,11,4: | 1 |
| 8 | Anesthesia for noncar- diac surgery in adults with congenital heart disease 显示文摘 | Cannesson M Earing MG Collange V | 2009 | Anesthesiolo- gy2009,111,2: | 1 |
| 9 | Expression ofGIV/Girdin,a metastasis-related protein,predicts patientsurvival in colon cancer 显示文摘 | Garcia-Marcos M Jung BH Ear J | 2011 | FASEB J2011,25,2: | 1 |
| 10 | Cytokine generation, promoter activation, and oxidant-independent NF-KB activation in a transfectable human neutrophilic cellular model 显示文摘 | EAR T MCDONALD P P | 2008 | BMC Immunol2008,9,: | 1 |
| 11 | Bacteriologic localization pattern in bacterial prostatitis and urethritis显示文摘 | M eares E M Stamey T A | 1968 | Invest Uro11968,5,: | 1 |
| 12 | Inflammatory cytokine expression is independent of the c-Jun n-terminal kinase/AP-1 signaling cascade in human neutrophils 显示文摘 | CLOUTIER A EAR T BORISSEVITCH O | 2003 | The Journal of Immunology2003,171,: | 1 |
| 13 | A GDI(AGS3)and aGEF(GIV)regulate autophagy by balancing G protein activity andgrowth factor signals显示文摘 | Garcia-Marcos M Ear J Farquhar MG | 2011 | Mol Biol Cell2011,22,5: | 1 |
| 14 | Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils 显示文摘 | CLOUTIER A EAR T BLAIS-CHARRON E | 2007 | J Leukoc Biol2007,81,2: | 1 |
| 15 | Genomes on line database (GOLD): A monitor of genome projects world-wide显示文摘 | Bernal A Ear U Kyrpides N | 2001 | Nucleic Acids Res2001,29,1: | 1 |
| 16 | Expression of GIV/Gird-in,a metastasis-related protein,predicts patient sur-vival in colon cancer显示文摘 | Garcia-Marcos M Jung B H Ear J | | 0,,02: | 1 |
| 17 | Mild Haemostatic Problems Associated with Congenital Heterozygous α2-Antiplasmin Deficiency显示文摘 | Leebeek FWG Stibbe J Knot EAR | 1998 | Thrombosis Haemostasis1998,79,1: | 1 |
| 18 | Expression of GIV/Girdin, a Metastasis-related protein, predicts patient survival in colon cancer 显示文摘 | Garcia-Marcos M Jung BH Ear J | 2011 | FASEB J2011,25,2: | 1 |
| 19 | The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin显示文摘 | Bhattacharyya A Ear US Koller BH | 2000 | J Biol Chem2000,275,23: | 1 |
| 20 | Journal of Clinical Nursing 5,1317-23显示文摘 | Carter B Commentary on Shields Pratt J - Hunter J(2006) Family centred eare=a review of qualitative studies | 2008 | J Clin Nuts2008,17,15: | 1 |