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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Sellar repair in endoscopic endonasal transsphenoidal surgery: results of 170cases 显示文摘 | Cavallo LM Esposito F | 2002 | Neurosurgery2002，51，6： | 1 |
| 3 | Laparoscopic treatment of congeni- tal ingui-nal hernia in children 显示文摘 | Montupet P Esposito C | 1999 | Pediatr Surg1999，34，3： | 1 |
| 4 | Predictive value of MRI vertebral end-plate signal changes (Modie) on outcome of surgically treated degenerative disc disease显示文摘 | Esposito P Pinheiro-Franeo JL Froelieh S | 2006 | Neuroehirurgie2006，52，： | 1 |
| 5 | Preparation and mechanical properties of edible pectin-soy flour films obtained in the absence or presence of transglutminase显示文摘 | Mariniello L Pierro P D Esposito C | 2003 | J Biotechnol2003，102，： | 1 |
| 6 | Lipoprotein metabolism during normal pregnancy显示文摘 | Brizzi P Tonolo G Esposito F | 1999 | Am J Obstet Gynecol1999，181，2： | 1 |
| 7 | Lipoma of the infiundibulum: a case report 显示文摘 | Esposito S Nardi P | 1987 | J Neurosurg1987，67，： | 1 |
| 8 | Cranio- pharyngiomas显示文摘 | CAPPABIANCA P CAVALLO L M ESPOSITO F | 2008 | J Neurosurg2008，109，1： | 1 |
| 9 | The efficacy of hor- izontal and vertical bone augmentation procedures for dental implants-a Cochrane systematic review 显示文摘 | Esposito M Grusovin MG Felice P | 2009 | Eur J Oral Implan- tol2009，2，3： | 1 |
| 10 | Effect of naloxone on morphine- induced changes in striatal dopamine metabolism and glutamate,ascorbic acid and uric acid release in freely moving rats显示文摘 | Enrico P Mura MA Esposito G | 1998 | Brain Res1998，797，1： | 1 |
| 11 | Sellar repair in endoscopic endonasal transsphenoidal surgery: results of 170 cases 显示文摘 | Cappabianca P Cavailo LM Esposito F | 2002 | Neurosurgery2002，51，： | 1 |
| 12 | Metabolic syn- drome and risk of cancer:a systematic review and meta- analysis显示文摘 | Esposito K Chiodini P Colao A | 2012 | Diabetes Care2012，35，11： | 1 |
| 13 | Labile plasma iron in iron overload:redox activity and susceptibility to chelation显示文摘 | Esposito BP Breuer W Sirankapracha P | 2003 | Blood2003，102，： | 1 |
| 14 | Speech-driven facial animation with realistic dynamics 显示文摘 | GUTIERREZ-OSUNA R KAKUMANU P ESPOSITO A | 2005 | IEEE Trans on Multimedia2005，7，1： | 1 |
| 15 | Impact of seropositivity to Chlamydia pneumoniae and anti - hHSP60 on cardiovascular events in hemodialysis patients显示文摘 | Esposito P | 2011 | Cell Stress Chaperones2011，16，2： | 1 |
| 16 | Culture conditions allow selection of different mesenchymal progenitors from adult mouse bone marrow显示文摘 | Esposito MT Di Noto R Mirabelli P | 2009 | Tissue Eng Part A2009，15，： | 1 |
| 17 | Covariance versus component-based estimations of performance in green supply chain management显示文摘 | De Giovanni P Esposito Vinzi V | 2012 | International Journal of Production Economics2012，135，2： | 1 |
| 18 | Olive oil and health: Summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008显示文摘 | J. López-Miranda F. Pérez-Jiménez E. Ros R. De Caterina L. Badimón M.I. Covas E. Escrich J.M. Ordovás F. Soriguer R. Abiá C. Alarcón de la Lastra M. Battino D. Corella J. Chamorro-Quirós J. Delgado-Lista D. Giugliano K. Esposito R. Estruch J.M. Fernandez- | 2009 | Nutrition Metabolism and Cardiovascular Diseases2009，，4： | 1 |
| 19 | Sellar/ tuberculum approach显示文摘 | CAPPABIANCA P CAVALLO L M ESPOSITO I | 2012 | Karer Publishers2012，26，： | 1 |
| 20 | Enamel matrix derivative for periodontal tissue regeneration in treatment of intrabony defects: a Cochrane systematic review显示文摘 | Esposito M Coulthard P Thomsen P | 2004 | J Dent Educ2004，68，8： | 1 |
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