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| 1 | Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence显示文摘AIM: To investigate biological prevention with flavonoids the recurrence risk of neoplasia was studied in patients with resected colorectal cancer and after adenoma polypectomy. METHODS: Eighty-seven patients, 36 patients with resected colon cancer and 51 patients after polypectomy, were divided into 2 groups: one group was treated with a flavonoid mixture (daily standard dose 20 mg apigenin and 20 mg epigallocathechin-gallat, n = 31) and compared with a matched control group (n = 56). Both groups were observed for 3-4 years by surveillance colonoscopy and by questionnaire. RESULTS: Of 87 patients enrolled in this study, 36 had resected colon cancer and 29 of these patients had surveillance colonoscopy. Among the flavonoid-treated patients with resected colon cancer (n = 14), there was no cancer recurrence and one adenoma developed. In contrast the cancer recurrence rate of the 15 matched untreated controls was 20% (3 of 15) and adenomas evolved in 4 of those patients (27%). The combined recurrence rate for neoplasia was 7% (1 of 14) in the treated patients and 47% (7 of 15) in the controls (P = 0.027). CONCLUSION: Sustained long-term treatment with a flavonoid mixture could reduce the recurrence rate of colon neoplasia in patients with resected colon cancer. | Harald Hoensch Bertram Groh Lutz Edler Wilhelm Kirch | 2008 | World Journal of Gastroenterology2008，14，14： | 12 |
| 2 | Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas显示文摘AIM:To investigate the metabolic enzymatic capacity of the colon mucosa to detoxify noxious carcinogenic compounds.METHODS:We investigated the activity of 2 conjugating enzymes-the microsomal uridine glucuronosyltransferase(UGT)and the cytosomal glutathione S-transferase(GST)in the uninvolved mucosa of the colon transversum and sigmoideum in patients with adenomatous polyps and colorectal cancer.Biopsies were taken from the mucosa during colonoscopies which were done for clinical(diagnostic)reasons.After storage,the biopsy material was homogenized and after differential centrifugation the enzyme assays were performed with 4-nitrophenol(UGT)and 1-chloro 2,4-dinitrobenzene(GST)as substrates.RESULTS:About 48 patients were included of which28 had adenomas and 20 had colorectal carcinomas confirmed by histopathology.Enzyme activities were expressed as nmol/mg per minute protein for the GST and as pmol/mg per minute protein for the UGT.Analysis of variance(F-test)indicated that both enzymes were more widely distributed in adenoma than in cancer patients.The means±SD were smaller for cancer patients:GST for adenomas 268±152 vs 241±69 for carcinomas and UGT for adenomas 197±200 vs 150±86 for carcinomas.CONCLUSION:Compared to patients with adenomatous colon polyps those with colorectal carcinoma exhibited a lower capacity of detoxifying enzyme metabolism and their activities clustered over a smaller range. | Harald P Hoensch Hennie MJ Roelofs Lutz Edler Wilhelm Kirch Wilbert HM Peters | 2013 | World Journal of Gastroenterology2013，19，36： | 3 |
| 3 | Public procurement and innovation—Resurrecting the demand side显示文摘 | Jakob Edler Luke Georghiou | 2007 | Research Policy2007，，7： | 2 |
| 4 | Bilateral optic neuritis evolved during tamoxifen treatment显示文摘 | Edler F Eyben V | 1986 | Cancer1986，58，： | 1 |
| 5 | Truncated hepatitis B virus RNA in human hepatocellular carcinoma: Its representation in patients with advancing age 显示文摘 | Beerheide W Zhou G Tang Y Edler L Schroeder CH | 1999 | Intervirology1999，42，： | 1 |
| 6 | “Changes in the strategic management of technology:results of a global benchmark survey”显示文摘 | Edler Jakob Frieder Meyer-Krahmer and Guido Reger (2002) | 2002 | R&D Management2002，32，2： | 1 |
| 7 | Angiopoietin-2 levels are as- sociated with disease progression in metastatic malignant melanoma 显示文摘 | Helfrich I Edler L Sucker A | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 8 | Changes in the strategic management of technology: results of a global ben- chamarking study显示文摘 | EDLER F M KRAHME G R | 2002 | RD Management2002，，32： | 1 |
| 9 | A boronic acid chalcone analog of combretastatin A-4 as a potent anti- proliferation agent 显示文摘 | Kong Y Wang K Edler M C | 2010 | Bioorg Med Chem2010，18，： | 1 |
| 10 | Motives to Patent: Empirical Evidence from Germany 显示文摘 | Blind K Edler J Frietsch R | 2006 | Research Policy2006，35，5： | 1 |
| 11 | Estradiol modulates anhedonia and behavioral despair in rats and negative affect in a subgroup of women at high risk for postpartum depression显示文摘 | Crystal Edler Schiller Michael W. O’Hara David R. Rubinow Alan Kim Johnson | 2013 | Physiology & Behavior2013，，： | 1 |
| 12 | The role of reproductive hormones in postpar- tum depression显示文摘 | Crystal Edler Schiller Samantha Meltzer-Brody David R Rubinow | 2015 | CNS spectrums2015，20，1： | 1 |
| 13 | Public procurement and innovation-Resurrecting the demand side显示文摘 | Jakob Edler Luke Georghiou | 2007 | Research Policy2007，36，9： | 1 |
| 14 | Outcome measurement in the correction of mandibular asymmetry 显示文摘 | Edler R Wertheim D Greenhill D | 2004 | Am J Orthod Dentofacial Orthop2004，125，4： | 1 |
| 15 | Public procurement and in novation-resurrecting the demand side显示文摘 | EDLER J GEORGHIOU L | 2007 | Researeh Policy2007，36，： | 1 |
| 16 | The use of vacuum-formed splints for temporary intermaxillary fixation in the management of unilateral condylar fractures显示文摘 | Nightingale C Edler R | 2001 | Br J Oral Maxillofac Surg2001，39，4： | 1 |
| 17 | Comparison of radiographic and photographic measurement of mandibular asymmetry显示文摘 | Edler R Wertheim D Greenhill D | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 18 | Investigation of Pd-C Cells to Improve Thermocouple Calibration显示文摘 | Pearce J V Edler F Elliott C J | 2011 | Metrologia2011，48，5： | 1 |
| 19 | Inhibition of tubulin polymerization by vitilevuamide, a bieyclic marine peptide, at a site distinct from colchicine, the vinca alka- loids, and dolastatin 10 显示文摘 | Edler M C Fernandez A M Lassota P | 2002 | Biochem Pharmacol2002，63，4： | 1 |
| 20 | Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10 显示文摘 | EDLER M C FERNANDEZ A M LASSOTA P | 2002 | Biochem Pharmacol2002，63，4： | 1 |
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