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| 1 | MICROSTRUCTURAL MODEL OF GATORIZED WASPALOY IN THE ISOTHERMAL FORGING PROCESS显示文摘A microstructural model, which was to predict the evolution of microstructure of Gatorized Waspeloy in the isothermal forcing process, was developed in terms of dynamic recrystallization and grain growth. Three steps of experiment were conducted during developing the model: (1) .Specimens were compressed in M FS testing machine; (2) Dynamic recrystallization and grain growth were discussed; (3) Dynamic recrys- tallization model and grain growth mode were set up. The agreement of simulated results and experimental data is fine. | J.P. Hu (Chongqing Iron and Steel Designing Research Institute, Chongqing 400013, China) J. Y. Zhuang, J.H. Du, Q. Deng, D. Feng and Z. Y. Zhong (Central Iron and Steel Research Institute, Beijing 100081, China) P. Janschek and J. Kramer (Thyssen Umformte | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，3： | 61 |
| 2 | Biofeedback therapy for chronic pelvic pain syndrome显示文摘Aim: To evaluate the efficacy of biofeedback therapy in patients with chronic pelvic pain syndrome(CPPS). Methods: From November 2001 to April 2002, patients visiting the Urological Outpatient Clinic of this Hospital were evaluated by means of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI)and classified by the NIH classification standard. Sixty-two patients of CPPS category Ⅲ were involved in this study. All patients had been treated by conventional approaches such as antibiotics and alpha-blockers for more than half a year without any improvement. The expressed prostatic secretion results were as follows: WBC 5 to 9/high power field, lipid +-+++ and bacterial culture negative. Their NIH-CPSI were 12-40. All the 62 cases complained of micturitional irritation (frequency, urgency, splitted stream and sense of residual urine), 32 cases, of pain or discomfort at the testicular, penile, scrotal, pelvic or rectal region and 13 cases, of white secretion-dripping. The patients were treated by the Urostym Biofeedback equipment (Laborie Co., Canada) 5 times a week for 2 weeks with a stimulus intensity of 15 mA-23 mA and duration of 20 minutes. Results: Sixty patients were significantly improved or cured, while no significant improvement in the remaining 2. No apparent side effect was observed. The NIH-CPSI dropped to 6 to 14 with an average reduction of 21 (P<0.01). In the 60 improved cases, pain was relieved after 2-3treatment courses and other symptoms disappeared after 4-5 courses. Conclusion: Biofeedback therapy is a safe and effective treatment for CPPS. Large randomized clinical trials are needed to confirm its efficacy and to explore the mechanism of action. ( Asian J Androl 2003 Jun; 5:155-158 ) | Zhang-Qun YE, Dan CAI, Ru-Zhu LAN, Guang-Hui DU, Xiao-Yi YUAN, Zhong CHEN, Yang-Zhi MA, You-Ming HU, Gui-Yun ZENGDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430030, China | 2003 | Asian Journal of Andrology2003，5，2： | 25 |
| 3 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 4 | Fundamental Theories and Key Technologies for Smart andOptimal Manufacturing in the Process Industry显示文摘Given the significant requirements for transforming and promoting the process industry, we present themajor limitations of current petrochemical enterprises, including limitations in decision-making, produc-tion operation, efficiency and security, information integration, and so forth. To promote a vision of theprocess industry with efficient, green, and smart production, modern information technology should beutilized throughout the entire optimization process for production, management, and marketing. To focuson smart equipment in manufacturing processes, as well as on the adaptive intelligent optimization of themanufacturing process, operating mode, and supply chain management, we put forward several key scien-tific problems in engineering in a demand-driven and application-oriented manner, namely:intelligentsensing and integration of all process information, including production and management information; collaborative decision-making in the supply chain, industry chain, and value chain, driven by knowledge; cooperative control and optimization of plant-wide production processes via human-cyber-physical in-teraction; and Q life-cycle assessments for safety and environmental footprint monitoring, in addition totracing analysis and risk control. In order to solve these limitations and core scientific problems, we furtherpresent fundamental theories and key technologies for smart and optimal manufacturing in the processindustry. Although this paper discusses the process industry in China, the conclusions in this paper can beextended to the larocess industry around the world. | Feng Qian Weimin Zhong Wenli Du | 2017 | Engineering2017，3，2： | 23 |
| 5 | Role of Notch signaling pathway in gastric cancer: A meta-analysis of the literature显示文摘AIM: To perform a meta-analysis to quantitatively summarize the evidence for the association between the Notch signaling pathway and gastric cancer(GC).METHODS: An electronic search of the MEDLINE, EMBASE and Chinese National Knowledge Infrastructure,which contain articles published from 1966 onwards,was conducted to select studies for this meta-analysis. RESULTS: Fifteen studies with a total of 1547 gastric cancer cases and 450 controls were included in this meta-analysis. Overall, the expression of Notch1,Notch2, Delta-like 4 and Hes1 was significantly higher in tumor tissues of GC compared to normal tissues.Specifically, stratified analyses showed that significantly increased expression of Notch1 was associated with non-cardia location, > 5 cm size, diffuse type, positive lymphovascular invasion and distal metastasis. Statistically significant higher expression of Notch3 was found in diffuse type GC. Jagged1 was also significantly over-expressed in diffuse type and poor differentiation type of GC. DLL4 was significantly over-expressed in advanced T stage, N stage and TNM stage in GC patients. However, the stratified analysis showed that there was no statistically significant difference in Hes1 expression between different subgroups. Sporadic reports showed that Notch1 and Jagged1 were independent poor prognostic predictors in GC.CONCLUSION: The Notch signaling pathway plays an important role in tumor progression of gastric cancer. | Xiao Du Zhong Cheng Yi-Han Wang Zi-Heng Guo Si-Qin Zhang Jian-Kun Hu Zong-Guang Zhou | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 6 | Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients显示文摘AIM: To compare apelin-13, a ligand of G-proteincoupled receptor which has been shown to be involved in retinal angiogenesis, and vascular endothelial growth factor(VEGF) serum levels in type 2 diabetes mellitus(T2DM) with or without retinopathy, and to investigate the relationship between the serum concentration of apelin-13 and diabetes retinopathy.METHODS: Sixty-nine patients with T2 DM were enrolled.Of the 69 patients, 16 had proliferative diabetic retinopathy(PDR group), 23 had non-PDR(NPDR group)and 30 had no retinopathy(T2DM group). Subjects' information, including demographics, medical history,and use of medications were recorded. Their serum samples were collected for measuring the levels of C-reactive protein(CRP), serum lipid and glycosylated hemoglobin. Apelin-13 and VEGF serum levels were measured by enzyme-linked immunosorbent assay.Kruskal-Wallis test and one-way ANOVA were used to compare the differences among these groups. Chi-square test was used to assess categorical variables.Correlations between variables were investigated by Spearman rho correlation test and stepwise regression analysis. All statistical analyses were performed through SPSS 17.0 software.RESULTS: Sex, age, body mass index(BMI), blood pressure, CRP, hemoglobin A1c(Hb A1c) have no significantly difference in the three groups. Serum level of apelin-13 was significantly elevated in PDR group as compared with T2 DM group(P =0.041). Differences of VEGF serum concentration in the three groups were statistically significant(P =0.007, P =0.007 and P <0.001,respectively). Spearman rho correlation test showed that serum apelin-13 was positively correlated with BMI,serum triglycerides, VEGF, but not with age, duration of diabetes, blood pressure, CRP, Hb A1 c and total-cholesterol. Stepwise regression analysis showed that BMI also significantly associated with serum apelin-13(P =0.002), while VEGF and serum triglycerides were irrelevant. CONCLUSION: This study elucidated a positive association of apelin-13 serum level with PDR, but not with VEGF. Apelin-13 may influence the promotion of PDR but unrelated with VEGF. | Jun-Hui Du Xia Li Rong Li Lin Xu Ran-Ran Ma Song-Fang Liu Zhong Zhang Hong-Zhi Sun | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 21 |
| 7 | Preliminary molecular epidemiology of the Staphylococcus aureus in lower respiratory tract infections: a multicenter study in China显示文摘 | LI De-zhi CHEN Yu-sheng YANG Jing-ping ZHANG Wei HU Cheng-ping LI Jia-shu MU Lan HU Ying-hui GENG Rong HU Ke CAI Shao-xi WAN Huan-ying WANG Qiu-yue WEI Li-ping DU Juan YU Qin ZHONG Xiao-ning WANG Rui-qin MA Jian-jun TIAN Gui-zhen WANG Si-qin GAO Zhan-cheng | 2011 | Chinese Medical Journal2011，，5： | 21 |
| 8 | Microwave synthesis of Li_2FeSiO_4 cathode materials for lithium-ion batteries显示文摘A novel synthetic method of microwave processing to prepare Li_2FeSiO_4 cathode materials is adopted.The Li_2FeSiO_4 cathode material is prepared by mechanical ball-milling and subsequent microwave processing.Olivin-type Li_2FeSiO_4 sample with uniform and fine particle sizes is successfully and fast synthesized by microwave heating at 700℃in 12 min.And the obtained Li_2FeSiO_4 materials show better electrochemical performance and microstructure than those of Li_2FeSiO_4 sample by the conventional solidstate reaction. | Zhong Dong Peng Yan Bing Cao Guo Rong Hu Ke Du Xu Guang Gao Zheng Wei Xiao | 2009 | Chinese Chemical Letters2009，20，8： | 20 |
| 9 | Status quo of soil petroleum contamination and evolution of bioremediation显示文摘Along with the rapid development of oil industries internationally,petroleum prospecting and exploitation activities are growing intensively.Especially in China,with the fastest economic growth in the world and shortage of petroleum resources,we are leading the practices of petroleum deep exploitation.Obviously,the risk of damage to the natural environment from these activities is high.Oil contamination in soils and groundwater is becoming a big issue along with pesticide pollution,which makes organic pollution prevention and control (OPPC) much more complex.In this paper,based on recent research on oil-contaminated soil at home and abroad,we make comments on the remediation technologies for polluted soil,emphasizing bioremediation techniques and degradation mechanisms in order to push forward research into bound organic pollution prevention and control (OPPC),especially in China. | Du Weidong Wan Yunyang Zhong Ningning Fei Jiajia ZhangZhihuan Chen Lijun Hao Jiming | 2011 | Petroleum Science2011，8，4： | 19 |
| 10 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 11 | Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model显示文摘Background and Objectives:Chronic kidney disease(CKD) is a growing public health problem with an urgent need for new pharmacological agents.Cordyceps cicadae is widely used in traditional Chinese medicine(TCM) and has potential renoprotective benefits.The current study aimed to determine any scientific evidence to support its clinical use.Methods:We analyzed the potential of two kinds of C.cicadae extract,total extract(TE) and acetic ether extract(AE),in treating kidney disease simulated by a subtotal nephrectomy(SNx) model.Sprague-Dawley rats were divided randomly into seven groups:sham-operated group,vehicle-treated SNx,Cozaar,2 g/(kg·d) TE SNx,1 g/(kg·d) TE SNx,92 mg/(kg·d) AE SNx,and 46 mg/(kg·d) AE SNx.Renal injury was monitored using urine and serum analyses,and hematoxylin and eosin(HE) and periodic acid-Schiff(PAS) stainings were used to analyze the level of fibrosis.The expression of type IV collagen(Col IV),fibronectin(FN),transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF) was detected by immunohistochemistry.Results:Renal injury,reflected in urine and serum analyses,and pathological changes induced by SNx were attenuated by TE and AE intervention.The depositions of Col IV and FN were also decreased by the treatments and were accompanied by reduced expression of TGF-β1 and CTGF.In some respects,2 g/(kg·d) of TE produced better effects than Cozaar.Conclusions:For the first time,we have shown that C.cicadae may inhibit renal fibrosis in vivo through the TGF-β1/CTGF pathway.Therefore,we conclude that the use of C.cicadae could provide a rational strategy for combating renal fibrosis. | Rong ZHU Yi-ping CHEN Yue-yi DENG Rong ZHENG Yi-fei ZHONG Lin WANG Lan-ping DU | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 18 |
| 12 | Cancer incidence and mortality in Zhejiang Province,Southeast China,2016:a population-based study显示文摘Backgrounds:Cancer is one of the main causes of death worldwide,seriously threatening human health and life expectancy.We aimed to analyze the cancer incidence and mortality rates during 2016 in Zhejiang Province,Southeast China.Methods:Data were collected from 14 population-based cancer registries across Zhejiang Province of China.Cancer incidence and mortality rates stratified by sex and region were analyzed.The crude rate,age-standardized rate,age-specific and region-specific rate,and cumulative rate were calculated.The proportions of 10 common cancers in different groups and the incidence and mortality rates of the top five cancers in different age groups were also calculated.The Chinese national census of 2000 and the world Segi population was used for calculating the age-standardized incidence and mortality rates.Results:The 14 cancer registries covered a population of 14,250,844 individuals,accounting for 29.13%of the population of Zhejiang Province.The total reported cancer cases and deathswere 55,835 and 27,013,respectively.The proportion ofmorphological verification(MV%)was 78.95%of the population,and percentage of incident cases identified through death certificates only(DCO%)was 1.23%with a mortality-to-incidence ratio(M/I ratio)of 0.48.The crude incidence rate in Zhejiang cancer registration areas was 391.80/105;the age-standardized incidence rate of the Chinese standard population(ASIRC)and the age-standardized incidence rate of theworld standard population(ASIRW)were 229.76/105 and 220.96/105,respectively.The incidence rate in men was higher than that inwomen.The incidence rate increased rapidly after 45 years of age and peaked in individuals aged 80 to 84 years.The top 10 incidence rates of cancers were lung cancer,female breast cancer,thyroid cancer,colorectal cancer,stomach cancer,liver cancer,prostate cancer,cervical cancer,esophageal cancer,and pancreatic cancer(from highest to lowest).The crude mortality rate in Zhejiang cancer registration areas was 189.55/105;the age-standardized mortality rate of the Chinese standard population(ASMRC)and the agestandardized mortality rate of the world standard population(ASMRW)were 94.46/105 and 93.42/105,respectively.The mortality rate in men was higher than that in women,and the male population in rural areas was higher than that in urban areas.The cancer mortality rate increased rapidly after 50 years of age and peaked in individuals aged 85+years.The top 10 mortality rates of cancers were lung cancer,liver cancer,stomach cancer,colorectal cancer,pancreatic cancer,esophageal cancer,female breast cancer,prostate cancer,lymphoma,and leukemia(from highest to lowest).Conclusions:Lung cancer,female breast cancer,thyroid cancer,colorectal cancer,prostate cancer,liver cancer,and stomach cancer were the most common cancers in Zhejiang Province.Effective prevention and control measures should be established after considering the different characteristics of cancers in urban and rural areas. | You-Qing Wang Hui-Zhang Li Wei-Wei Gong Yao-Yao Chen Chen Zhu Le Wang Jie-Ming Zhong Ling-Bin Du | 2021 | Chinese Medical Journal2021，，16： | 18 |
| 13 | Synthesis of spherical LiNi_(0.8)Co_(0.15)Al_(0.05)O_2 cathode materials for lithium-ion batteries by a co-oxidation-controlled crystallization method显示文摘球形的 Ni0.8Co0.15Al0.05OOH 先锋,由一个 co-oxidation-controlled 结晶化方法准备了,被用来综合 LiNi0.8Co0.15Al0.05O2。获得的 LiNi0.8Co0.15Al0.05O2 材料看了优秀电气化学的性能,与 193.5 mAh/g 的一个起始的分泌物能力和在 50 个周期以后的 95.1% 的能力保留什么时候以在 2.8 和 4.3 V 之间的 0.2 C 率骑车了。 | Wan Min Liu Guo Rong Hu Zhong Dong Peng Ke Du Yan Bing Cao Qiang Liu | 2011 | Chinese Chemical Letters2011，22，9： | 17 |
| 14 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 15 | Drug-resistant genes carried by Acinetobacter baumanii isolated from patients with lower respiratory tract infection显示文摘 | DAI Ning LI De-zhi CHEN Ji-chao CHEN Yu-sheng GENG Rong HU Ying-hui YANG Jing-ping DU Juan HU Cheng-ping ZHANG Wei LI Jia-shu YU Qin WAN Huan-ying MU Lan ZHONG Xiao-ning WEI Li-ping MA Jian-jun WANG Qiu-yue HU Ke TIAN Gui-zhen CAI Shao-xi WANG Rui-qin HE Bei WANG Si-qin WANG Zhan-wei ZHAO Su-rui GAO Zhan-cheng | 2010 | Chinese Medical Journal2010，，18： | 13 |
| 16 | Expression of E-cadherin,beta-catenin,cathepsin D,gelatinases and their inhibitors in invasive ductal breast carcinomas显示文摘背景 E-cadherin, beta-catenin,组织蛋白酶 D,矩阵 metalloproteinase (MMP )-2, MMP-9, metalloproteinase (TIMP ) 的织物禁止者 -1 和 TIMP-2 都是侵略相关的蛋白质。在侵略 ductal 胸癌的这些蛋白质的表达式模式,和他们有已知的 clinicopathological 参数,肿瘤复发和雌激素受体的表达式的协会(嗯),孕酮受体( PR ), PS2 和 c-erbB2 很好没在一套 94 侵略 ductal 胸癌在中国 patients.Methods 被学习,这些分子的标记的蛋白质表达式被 immunohistochemistry ,和他们的协会与已知的 clinicopathological 参数调查, tumo 另外,在这些蛋白质的表情之间的相互关系是保存的 studied.Results 膜 E-cadherin 表示与迟了的肿瘤舞台和肿瘤复发被联系,而减少的 junctional beta-catenin 与积极淋巴节点地位和 c-erbB2 overexpression.Positive 联系了在肿瘤 stromal 组织蛋白酶 D 染色,房间与迟了的肿瘤舞台显示了一个重要协会。在癌症房间的 MMP-2 的高表示与大肿瘤尺寸和 PR 被联系积极表示。TIMP-2 表示断然与肿瘤复发被联系。另外,在这些 biomarkers 的表情之间的相互关系也被估计。在癌症房间染色的组织蛋白酶 D 相反地与它在 stromal 房间染色被相关,并且相反地也相关, MMP-2 在肿瘤 stromal 房间染色。在 stromal 房间的 MMP-2 表示与 TIMP-2 表示显示了反的关联。MMP-9 表示与表示可能精确地具有在更多的一些帮助预言侵略 ductal 胸癌的预后的 E-cadherin, beta-catenin,组织蛋白酶 D, MMP-2 和 TIMP-2 的 TIMP-1 和 TIMP-2 expression.Conclusion 评估显示了平行协会。 | ZHANG Yun-gang DU Juan TIAN Xin-xia ZHONG Yan-feng FANG Wei-gang | 2007 | Chinese Medical Journal2007，，18： | 13 |
| 17 | Effectiveness of Auricular Acupressure for Acute Postoperative Pain after Surgery: A Systematic Review and Meta-Analysis显示文摘Objective: To identify the effectiveness of auricular acupressure(AA) in patients with acute postoperative pain after surgery by systematic review. Methods: A search of randomized controlled trials was conducted in 5 English medical electronic databases and 4 Chinese databases. Two reviewers independently retrieved related studies, assessed the methodological quality, and extracted data with a standardized data form. Meta-analyses were performed using all time-points meta-analysis. Results: A total of 26 studies with 1,682 participants were included. Results showed that compared with conventional therapy, AA significantly improved the total effective rate [risk ratio=1.25, 95% confidence interval(CI), 1.13 to 1.37, P<0.0001; heterogeneity: P<0.0001, I^2=85%]. In the subgroup analysis, the results changed in different follow-up time and surgery categories. The pain relief in the AA group might be the most significant at 72 h after surgery(mean difference=–0.85, 95% CI, –1.20 to –0.50, P<0.0001) and in abdominal surgery(mean difference=–1.15, 95% CI, –1.41 to –0.90, P<0.0001). Sensitivity analysis demonstrated that the results of this meta-analysis were stable. No serious adverse effects were recorded. Conclusions: It was recommended to provide AA to patients with acute postoperative pain. However, a more accurate estimate of the effect requires further rigorously designed large-scale and high-quality RCTs for improving acute postoperative pain after surgery. | ZHONG Qin WANG Di BAI Ya-mei DU Shi-zheng SONG Yu-lei ZHU Jing | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 12 |
| 18 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 19 | 3D Chromatin Architecture of Large Plant Genomes Determined by Local A/B Compartments显示文摘染色体的空间组织在基因表示的规定起一个重要作用。然而,核心动物染色体的结构的特征例如拓扑地联系的域(男孩) 和染色质环,不在极其紧缩的 Arabidopsis 染色体是突出的。在这研究,我们检验 ? 染色质建筑学,以及他们的 DNA methylation, histone 修正,可存取的染色质,和基因表示玉米,有染色体的西红柿,蜀黍,狐尾稷,和米饭缩放从 0.4 ? 到 2.4 Gb。我们发现这些植物染色体能被划分成象哺乳动物一样 A/B 分隔空间。在更高的分辨率,这些植物的染色体能进一步被划分到反映他们的 euchromatin, heterochromatin,和 polycomb 地位的本地 A/B 分隔空间。在所有这些植物的染色质被组织成没越过种类被保存的领域。他们显示出类似到果蝇分隔空间领域,并且被聚类进活跃, polycomb,压抑、中间的类型基于他们的 transcriptional 活动和 epigenetic 签名,与有本地 A/B 分隔空间连接的领域边阶重叠。在大玉米和西红柿染色体,我们观察了广泛的染色质环。不同于在 TAD 边阶被充实的哺乳动物的染色质环,然而种染色质环经常在压抑的域外面在基因岛之间被形成 ? 并且仔细与活跃分隔空间被联系。我们的学习显示植物有复杂、唯一的 3D 染色质体系结构,它要求 ? 阐明的进一步的学习他们的生物功能。 | Pengfei Dong Xiaoyu Tu Po-Yu Chu Peitao Lu Ning Zhu Donald Grierson Baijuan Du Pinghua Li Silin Zhong | 2017 | Molecular Plant2017，10，12： | 12 |
| 20 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
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