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| 1 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 2 | All gene-sized DNA molecules in four species of hypotrichs haye the same terminal sequence and an unusual 3' terminus显示文摘 | KlobutcherL A Swanton M T Donnini P | 1981 | Proc Natl Acad Sci1981，78，： | 1 |
| 3 | An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis显示文摘 | Choudhuri R Zhang HT Donnini S | 1997 | Cancer Res1997，57，9： | 1 |
| 4 | Expression and localization of placenta growth factor and PLFG receptors in human meningiomas显示文摘 | Donnini S Machein MR Plate KH | 1999 | J Pathol1999，189，1： | 1 |
| 5 | The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells 显示文摘 | Taraboletti G Morbidelli L Donnini S | 2000 | Faseb J2000，14，12： | 1 |
| 6 | Influence of mild bone marrow fibrosis on response of INT2/high risk MDS patients to azacitidine 显示文摘 | Sanna A Gozzini A Donnini I | 2011 | Leuk Res2011，35，1： | 1 |
| 7 | Development of new drugs in angiogenesis显示文摘 | Ziche M Donnini S Morbidelli L | 2004 | Curr Drug Targets2004，5，5： | 1 |
| 8 | A Novel Pharmacologieal Approach for Paraquat Poisoning in Rat and A549 Cell Line Using Ambroxol,a Lung Surfactant Synthesis Inducer显示文摘 | SALMONA M DONNINI M PERIN L | 1992 | Food Chem Toxicol(S0308-8146)1992，30，9： | 1 |
| 9 | Development of new drugs in an-giogenesis显示文摘 | Ziche M Donnini S Morbidelli L | 2004 | Curr Drug Targets2004，5，5： | 1 |
| 10 | Development of new drugs in anglogenesis 显示文摘 | ZICHE M DONNINI S MORBIDEILE L | 2004 | Curt Drug Targets2004，5，5： | 1 |
| 11 | AUFI is abel-2 A + U - rich element - binding protein involved in bcl - 2 mRNA destabilization during apoptosis 显示文摘 | Lapucci A Donnini M Papucci L | 2002 | Journal of Bio- logical Chemistry2002，277，16： | 1 |
| 12 | Development of new drugs in angio- genesis显示文摘 | Ziche M Donnini S Morbidelli L | 2004 | Curt Drug Targets2004，5，5： | 1 |
| 13 | An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis 显示文摘 | Choudhuri R Zhang HT Donnini S | 1997 | Cancer Res1997，57，2： | 1 |
| 14 | Reactive oxygen species modulate Zn2+-induced apoptosis in cancer cells 显示文摘 | Provinciali M Donnini A Argentati K | 2002 | Free Radic Biol Med2002，32，5： | 1 |
| 15 | Development of new drugs in angiogenesis显示文摘 | Ziche M Donnini S Morbidelli L | 2004 | Curr Drug Targets2004，5，5： | 1 |
| 16 | Reactive oxygen species modulate Zn^2+-induced apoptosis in cancer cells显示文摘 | Provinciali M Donnini A Argentati K | 2002 | Free Radic Biol Med2002，32，5： | 1 |
| 17 | Reactive oxy- gen species modulate Zn (2 + )-induced apoptosis in cancer cells显示文摘 | Provinciali M Donnini A Argentati K | 2002 | Free Radic Biol Med2002，32，5： | 1 |
| 18 | Glucose May Induce Cell Death through a Free Radical-Mediated Mechanism显示文摘 | Debora Donnini Anna Maria Zambito Giuseppina Perrella Francesco Saverio Ambesi-Impiombato Francesco Curcio | 1996 | Biochemical and Biophysical Research Communications1996，，2： | 1 |
| 19 | Expression and localiza- tion of placenta growth factor and P1GF receptors in human menin- giomas显示文摘 | Donnini S Machein MR Plate KH | 1999 | J Pathol1999，189，1： | 1 |
| 20 | An angiogenic role for the neurokines midkine and pleiotrophin in tumorigenesis显示文摘 | RANGANA CHOUDHURI ZHANG HUA-TANG SANDRA DONNINI | 1997 | Cancer Res1997，57，： | 1 |
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