|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 2 | 中、低收入国家卫生智囊团的实践影响政策变化显示文摘近年来,中、低收入国家独立卫生政策研究机构的数量与日俱增,原因在于政府研究能力有限和民主化进程中的压力。本研究的目标是:(1)调查中﹑低收入国家中卫生政策研究机构对卫生政策的议程设置﹑制定﹑执行、监管和评估所作的贡献;(2)评估包括组织形式和结构在内的哪些因素支持中﹑低收入国家的卫生政策研究机构对卫生政策发挥积极作用。本研究在孟加拉﹑加纳﹑印度﹑南非﹑乌干达和越南选取了6家卫生政策研究机构开展案例研究,研究对象包括两个非政府组织、两所大学和两个政府办政策研究机构。案例研究通过文献查阅、财务信息分析、对工作人员和其他利益相关人员进行半结构式访谈,以及对结论草案进行多次反馈等方式开展。其中有些机构对他们各自国家的政策发展作出了巨大贡献。这些机构都积极建言献策,多数从事与政策相关的研究,而开展政治对话﹑系统评价或委托性研究的机构则相对较少。这些机构所开展的工作大多以政府或出资人的需求为导向,多数机构的主要成果一般为研究报告,经常与面向政府官员的口头汇报相结合。在支持对政策的有效参与方面,有几个关键因素,其中包括支持性的政策环境﹑管理和财务的相对独立性,以及与决策者建立可增进信任和影响的密切关系。当研究机构与政府之间的正式关系未处在重要位置时,政府内部单位则面临相当大的困难。 | Sara Bennett Adrijana Corluka Jane Doherty Viroj Tangcharoensathlen Walaiporn Patcharanarumol Amar Jesani Joseph Kyabaggu Grace Namaganda A M Zakir Hussain Ama de-Graft Aikins | 2012 | 中国卫生政策研究2012，5，8： | 6 |
| 3 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 4 | Endoscopic evaluation in diagnosis and management of inflammatory bowel disease显示文摘Endoscopy is a keystone in the management of patients with inflammatory bowel disease(IBD).It is the fundamental diagnostic tool for IBD,and can help discern between ulcerative colitis and Crohn's disease.Endoscopic assessment provides an objective end point in clinical trials,and identifies patients in clinical practice who may benefit from treatment escalation and may assist risk stratification in patients seeking to discontinue therapy.Recent advances in endoscopic assessment of patients with IBD include video capsule endoscopy,and chromoendoscopy.Technological advances enable improved visualization and focused biopsy sampling.Endoscopic resection and close surveillance of dysplastic lesions where feasible is recommended instead of prophylactic colectomy. | Carthage P Moran Barra Neary Glen A Doherty | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 3 |
| 5 | Interspace distraction and graft subsidence after anterior lumbar fusion with femoral strutallo graft 显示文摘 | Kumar A Kozak JA Doherty BJ | 1993 | Spine1993，18，： | 2 |
| 6 | Peptide lipid interactions of the betahairpin antimicrobial peptide tachyplesin and its linear derivatives from solid state NMR显示文摘 | Doherty T Waring A J Hong M | 2006 | Bioehim Biophys Aeta2006，1758，9： | 1 |
| 7 | Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo 显示文摘 | DOHERTY A S MANN M R TREMBLAY K D | 2000 | Biology of Reproduction2000，62，： | 1 |
| 8 | Moral hazard,basis risk and gap insurance显示文摘 | Doherty N A Richter A | 2002 | Journal of Risk and Insurance2002，69，： | 1 |
| 9 | JNKI physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1- mediated apoptosis 显示文摘 | Chang N S Doherty J Ensign A | 2003 | J Biol Chem2003，278，11： | 1 |
| 10 | Legislative smoking bans forreducing secondhand smoke exposure, smoking prevalence and tobacco consumption显示文摘 | Callinan JE Clarke A Doherty K | 2010 | Cochrane Database Syst Rev2010，14，00： | 1 |
| 11 | Current issues in recrystallization:a review显示文摘 | Doherty R D Hughes D A | 1997 | Materials Science and Engineering A1997，238，： | 1 |
| 12 | Neural Evidence for Inequality - averse Social Preferences 显示文摘 | Tricomi E Rangel A Camerer C F Doherty J P | 2010 | Na- ture2010，463，： | 1 |
| 13 | Predictors of drop-out from an outpatient cardiac rehabilitation programme显示文摘 | Yohannes A M Yalfani A Doherty P | | 0，，03： | 1 |
| 14 | High performance LiFePO4 electrode materials: Influence of colloidal particle morphology and porosity on lithium-ion battery power capability 显示文摘 | DOHERTY C M CARUSO R A DRUMMOND C J | 2010 | Energy Environ Sci2010，3，： | 1 |
| 15 | Histologic cho-rioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants 显示文摘 | StrunkT Doherty D Jacques A etal | 2012 | Pediatrics2012，129，1： | 1 |
| 16 | Microchannel wall coatings for protein separations by capillary and chip electrophoresis显示文摘 | Meagher R J Albarghouthi M N | 2003 | Electrophoresis2003，24，： | 1 |
| 17 | Better understanding of plant and pilot plant operations using on-line mass spectrometry 显示文摘 | DESJARDIN M A DOHERTY S J GILBERT J R | 1995 | Process Control Qual1995，6，： | 1 |
| 18 | 2-Fluorine-18-fluoro-2-de- oxy-d-glucose positron emission tomography in the pretreatment staging of Hodgkin' s disease: influence on patient management in a single institution 显示文摘 | Partridge S Timothy A O' Doherty MJ | 2000 | Ann Oncol2000，11，10： | 1 |
| 19 | Regulation of mouse embryonic stem cell neural differentiation by retinoic acid 显示文摘 | Kim M Habiba A Doherty JM | 2009 | Dev Biol2009，328，2： | 1 |
| 20 | Current issues in recrystallization:a review显示文摘 | DOHERTY R D HUGHES D A HUMPHREYS F J JONAS J J JENSEN D J KASSNER M E KING W E MCNELLEY T R MCQUEEN H J ROLLETT A D | 1997 | Materials Science and Engineering A1997，238，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员