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| 1 | Comparison of early enteral nutrition in severe acute pancreatitis with prebiotic fiber supplementation versus standard enteral solution:A prospective randomized double-blind study显示文摘AIM: To compare the benefi cial effects of early enteral nutrition (EN) with prebiotic fiber supplementation in patients with severe acute pancreatitis (AP).METHODS: Thirty consecutive patients with severe AP, who required stoppage of oral feeding for 48 h, were randomly assigned to nasojejunal EN with or without prebiotics. APACHE Ⅱ score, Balthazar’s CT score and CRP were assessed daily during the study period.RESULTS: The median duration of hospital stay was shorter in the study group [10 ± 4 (8-14) d vs 15 ± 6 (7-26) d] (P < 0.05). The median value of days in intensive care unit was also similar in both groups [6 ± 2 (5-8) d vs 6 ± 2 (5-7) d]. The median duration of EN was 8 ± 4 (6-12) d vs 10 ± 4 (6-13) d in the study and control groups, respectively (P > 0.05). Deaths occurred in 6 patients (20%), 2 in the study group and 4 in the control group. The mean duration of APACHE Ⅱ normalization (APACHE Ⅱ score < 8) was shorter in the study group than in the control group (4 ± 2 d vs 6.5 ± 3 d, P < 0.05). The mean duration of CRP normalization was also shorter in the study group than in the control group (7 ± 2 d vs 10 ± 3 d, P < 0.05).CONCLUSION: Nasojejunal EN with prebiotic fiber supplementation in severe AP improves hospital stay, duration nutrition therapy, acute phase response and overall complications compared to standard EN therapy. | Tarkan Karakan Meltem Ergun Ibrahim Dogan Mehmet Cindoruk Selahattin Unal | 2007 | World Journal of Gastroenterology2007，13，19： | 50 |
| 2 | 旅游目的地体验价值:维度辨识、量表开发与验证显示文摘旅游目的地并未须同时具备观赏价值、科学考察价值、历史文化价值等,对于旅游者来说,只要有一种价值非常突出,就足以吸引他们前来旅游。目前,虽然众多学者纷纷赞同体验价值的重要性,但研究成果多关注于'态度-行为'的必然联系,片面地聚焦于体验价值对旅游者行为,特别是游后行为产生的影响,由此对旅游者满意度和忠诚度进行判断,这些研究忽略了目的地体验价值本身所富含的时间规律、空间尺度及体验主体的实践性表达。文章采用质性研究与定量研究相结合的方法,探析旅游目的地体验价值的结构与内涵。研究结果表明,旅游目的地体验价值是以功能价值、享乐价值与符号价值为核心,包含放松、复愈、交流、社会声望等8个子范畴,该量表具有良好的信度与效度。该研究有利于目的地管理者更全面、深刻地理解体验价值的内涵,并为构建基于体验价值的目的地深度旅游体验提供必要的理论基础和技术支持。 | 那梦帆 谢彦君 Dogan Gursoy | 2019 | 旅游学刊2019，34，12： | 36 |
| 3 | 景区规范类标识牌劝说效果研究——基于语言风格与颜色效价的匹配影响显示文摘文章基于情绪启动效应和规范焦点理论,研究了景区规范类标识牌语言风格对旅游者不文明行为的劝说效果,探索标识牌颜色效价与语言风格匹配方式对旅游者行为意愿的影响。研究结果表明:(1)景区标识牌语言风格(理性诉求vs.感性诉求)对旅游者劝说效果影响显著。(2)颜色在中国游客的认知经验中具有积极和消极的心理效价,当标识牌语言风格与标识牌颜色效价(积极vs.消极)达成匹配时,劝说效果更好。(3)概念流畅性是语言风格与颜色效价匹配影响劝说效果的中介变量。文章为提高旅游景区标识牌对旅游不文明行为的道德教育和干预效果提供了理论和方法指导。 | 张梦 潘莉 Dogan GURSOY | 2016 | 旅游学刊2016，31，3： | 15 |
| 4 | Circulating microRNAs in patients with non-alcoholic fatty liver disease显示文摘AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. | Serkan Dogan Gokmen Zararsiz Sebnem Gursoy Kadri Guven Omer Ozbakir Munis Dundar Mehmet Yucesoy | 2014 | World Journal of Hepatology2014，6，8： | 13 |
| 5 | Recent progress in CFD for naval architecture and ocean engineering显示文摘An overview is provided of CFDShip-Iowa modeling, numerical methods and high performance computing(HPC), including both current V4.5 and V5.5 and next generation V6. Examples for naval architecture highlight capability and needs. High fidelity V6 simulations for ocean engineering and fundamental physics describe increased resolution for analysis of physics of fluids. Uncertainty quantification research is overviewed as the first step towards development stochastic optimization. | STERN Frederick WANG Zhaoyuan YANG Jianming SADAT-HOSSEINI Hamid MOUSAVIRAAD Maysam BHUSHAN Shanti DIEZ Matteo YOON Sung-Hwan WU Ping-Chen YEON Seong Mo DOGAN Timur KIM Dong-Hwan VOLPI Silvia CONGER Michael MICHAEL Thad XING Tao THODAL Robert S. GRENESTEDT Joachim L. | 2015 | Journal of Hydrodynamics2015，27，1： | 12 |
| 6 | Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure显示文摘AIM: To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure (CRF).METHODS: Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori (H pylori) and CRF status. Groups were labeled as follows: 1a: normal renal function, H pylori negative (n = 12), 1b: normal renal function,H pylori positive (n = 11), 2a: CRF, H pylori negative (n = 10), 2b: CRF, H pylori positive (n = 11). Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation,antral biopsy specimens were taken from each patient.In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen (PCNA) labeling indexes (LI) were assessed with immunohistochemical staining method.RESULTS: For groups 1a, 1b, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5,60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22,respectively. When the one-way ANOVA test was applied,statistically significant differences were detected between the groups for both Bax LI (P = 0.004 <0.01) and PCNA LI (P = 0.009 <0.01). When groups were compared further in terms of Bax LI and PCNA LI with Tukey's HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups 1a and 2b (P = 0.006 <0.01).CONCLUSION: In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells. | Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz Sedat Boyacioglu | 2005 | World Journal of Gastroenterology2005，11，45： | 11 |
| 7 | Comparison of double balloon enteroscopy in adults and children显示文摘AIM: To compare results of double balloon enteroscopy (DBE) procedures in pediatric and adult patients. METHODS: The medical files of patients who underwent DBE at Gazi University School of Medicine, Ankara, Turkey between 2009 and 2011 were examined retrospectively. Adult and pediatric patients were compared according to DBE indications, procedure duration, final diagnosis, and complications. DBE procedures were performed in an operating room under general anesthesia by two endoscopists. An oral or anal approach was preferred according to estimated lesion sites. Overnight fasting of at least 6 h prior to the start of the procedure was adequate for preprocedural preparation of oral DBE procedures. Bowel cleansing was performed by oral administration of sennosides A and B solution, 2 mL/kg, and anal saline laxative en-ema. The patients were followed up for 2 h after the procedure in terms of possible complications. RESULTS: DBE was performed in 35 patients (5 pediatric and 30 adult). DBE procedures were performed for abdominal pain, chronic diarrhea, bleeding, chronic vomiting, anemia, and postoperative evaluation of anastomosis. Final diagnosis was diffuse gastric angiodysplasia (n = 1); diffuse jejunal angiodysplasia (n = 1); ulceration in the bulbus (n = 1); celiac disease (n = 1); low differentiated metastatic carcinoma (n = 1); PeutzJeghers syndrome (n = 1); adenomatous polyp (n = 1) and stricture formation in anastomosis line (n = 1). During postprocedural follow-up, abdominal pain and elevated amylase levels were noted in three patients and one patient developed abdominal perforation. CONCLUSION: With the help of technological improvements, we may use enteroscopy as a safe modality more frequently in younger and smaller children. | Odul Egritas Gurkan Tarkan Karakan Ibrahim Dogan Buket Dalgic Selahattin Unal | 2013 | World Journal of Gastroenterology2013，19，29： | 11 |
| 8 | 【原创论文】同侧和对侧大鼠睾丸缺血再灌注损伤的生化效应和褪黑激素对此的保护作用显示文摘睾丸扭转(TT),是一个多发于青春期男性的泌尿急症,如果不及时治疗,可致不孕不育。睾丸扭转所致缺血再灌注(I/R)损伤在睾丸损伤的病理生理过程中起一定作用。我们研究了褪黑激素在单侧睾丸扭转大鼠中同侧和对侧睾丸的氧化损伤效应:将21只青春期雄性Wistar大鼠分成三组,每组七只,处理如下:第1组(假手术组):行左睾丸和双边睾丸假切除术;第2组(I/R组):通过以下方式诱发缺血再灌注损伤(顺时针720°旋转左侧睾丸2小时,2小时后复位):第3组(I/R+MEL组):大鼠经诱导缺血再灌注损伤和一次性褪黑激素注射(50mgkg-1,i.p)。处理后离体分离各组大鼠双侧睾丸,用于检测睾丸组织中抗氧化过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶的活性,丙二醛、蛋白质羰基和一氧化氮的组织水平。较对照组,褪黑激素注射组同侧睾丸的脂质过氧化水平,相关酶活性降低,具有显著性(P〈0.05),而在对侧的睾丸中相关酶活性变化无统计学意义(P〉0.05)。在对侧睾丸中,丙二醛水平改变具有明显统计学意义(P=0.009)。应用褪黑素能减轻老鼠同侧睾丸扭转所致缺血再灌注损伤的不利影响,而对于对侧睾丸,睾丸扭转影响不大。 | Bekir S Parlaktas Dogan Atilgan Huseyin Ozyurt Yusuf Gencten Ali Akbas Fikret Erdemir Nihat Uluocak | 2014 | Asian Journal of Andrology2014，16，2： | 10 |
| 9 | Diagnosis and treatment of gallbladder perforation显示文摘AIM: To present our clinical experience with gallbladder perforation cases. METHODS: Records of 332 patients who received medical and/or surgical treatment with the diagnosis of acute cholecystitis in our clinic between 1997 and 2006 were reviewed retrospectively. Sixteen (4.8%) of those patients had gallbladder perforation. The parameters including age, gender, time from the onset of symptoms to the time of surgery, diagnostic procedures, surgical treatment, morbidity, and mortality were evaluated. RESULTS: Seven patients had typeⅠgallbladder perforation, 7 type Ⅱ gallbladder perforation, and 2 type Ⅲ gallbladder perforation according to Niemeier’ s classification. The patients underwent surgery after administration of intravenous electrolyte solutions, and were treated with analgesics and antibiotics within the first 36 h (mean 9 h) after admission. Two patients died of sepsis and multiple organ failure in the early postoperative period. Subhepatic abscess, pelvic abscess, pneumonia, pancreatitis, and acute renal failure were found in 6 patients. CONCLUSION: Early diagnosis and emergency surgical treatment of gallbladder perforation are of crucial importance. Upper abdominal computerized tomography for acute cholecystitis patients may contribute to the preoperative diagnosis of gallbladder perforation. | Hayrullah Derici Cemal Kara Ali Dogan Bozdag Okay Nazli Tugrul Tansug Esra Akca | 2006 | World Journal of Gastroenterology2006，12，48： | 9 |
| 10 | 基于特征价格模型的住宅需求价格弹性分析——深圳住宅市场实证研究显示文摘基于特征价格模型(hedonic model)分析住宅价格包络函数曲线形态,边际价格增长速度随着特定特征值递增从呈现下降趋势转为呈上升趋势,即均衡价格曲线从凹向特征值轴转为凸向特征值轴。通过对深圳经济特区内外的两个住宅交易子样本进行hedonic分析,结果表明,均衡价格的增长速度随着特征变量面积的变化呈现由凹变凸的趋势,表明在收入或投资影响下市场存在对面积较大的住宅的偏好。这一结果意味着可从面积上将住宅分为'住所'和'投资'两个组成部分,分界点即为住宅均衡价格曲线由凹变凸的拐点。凸曲线形态表明购买者愿意支付更高边际价格以获得较大的住宅,同时,均衡价格存在吸收外部负面影响的空间,即曲线凸度可在一定程度上承受外部因素如物业税(或房产税)对住宅价格可能产生的负面影响,并使价格曲线达到新的均衡。 | 陈勇 John M.Clapp Dogan Tirtiroglu | 2011 | 城市发展研究2011，18，2： | 8 |
| 11 | Confounders of uric acid level for assessing cardiovascular outcomes显示文摘We read the article entitled Serum uric acid as a prognostic marker in the setting of advanced vascular disease:a prospective study in the elderly by Stolfo,et al.[1] with great interest.The authors evaluated the association of serum uric acid (SUA) levels with adverse cardiovascular events and deaths in an elderly population affected by advanced atherosclerosis.They founded meaningful association between SUA levels and of cardiovascular events and cancer related death.We believe that these findings will lead for further studies on uric acid. | Mehmet Dogan Omer Uz Mustafa Aparci Murat Atalay | 2016 | Journal of Geriatric Cardiology2016，13，2： | 6 |
| 12 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 13 | 利用铝电解槽废旧阴极碳热还原铬铁矿(英文)显示文摘铝电解槽废旧阴极(SPL)是铝电解生产过程中产生的废料,被用作造渣熔剂与碳源来碳热还原铬铁矿。本研究的主要目标是促进碳热还原过程中铬铁合金颗粒的生长,以利于后续过程中合金与渣相的分离。实验证明相对于采用石墨作为还原剂,SPL中的碳组分能够更有效地还原铬铁矿。铬铁矿还原过程中矿物颗粒表面形成惰性的尖晶石层(MgAl_2O_4),从而阻碍反应的进行以及铬铁合金的生长。SPL中的造渣组分(例如霞石及NaF)在较低温度下(约1300℃)形成熔渣,并部分熔解尖晶石以及铬铁矿相。通过破坏铬铁矿颗粒表面的惰性尖晶石层、促进传质过程以及提高还原温度(例如1500℃)实现铬铁合金颗粒的生长。在还原温度为1500℃以及采用SPL作为添加剂条件下,还原得到较为粗大的铬铁合金颗粒,采用淘析法能够实现合金与渣相的有效分离。 | 于大伟 Dogan PAKTUNC | 2019 | Transactions of Nonferrous Metals Society of China2019，29，1： | 5 |
| 14 | Survival advantage for irinotecan versus best supportive care as second-line chemotherapy in gastric cancer – A randomised phase III study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)显示文摘 | Peter C. Thuss-Patience Albrecht Kretzschmar Dmitry Bichev Tillman Deist Axel Hinke Kirstin Breithaupt Yasemin Dogan Bernhard Gebauer Guido Schumacher Peter Reichardt | 2011 | European Journal of Cancer2011，，15： | 5 |
| 15 | Ceftriaxone-induced toxic hepatitis显示文摘Toxic hepatitis or drug-induced liver injury encompasses a spectrum of clinical disease ranging from mild biochemical abnormalities to acute liver failure.The advantages of a long half-life,wide spectrum,high tissue penetration rate,and a good safety profile,make ceftriaxone,a third-generation cephalosporin,a frequent choice in the treatment of childhood infections.Previous studies have reported a few cases of high aspartate aminotransferase and alanine aminotransferase levels,along with three cases of hepatitis caused by ceftriaxone.Here,we report a case of drug-induced toxic hepatitis in a patient who was treated with ceftriaxone for acute tonsillitis. | Erdal Peker Eren Cagan Murat Dogan | 2009 | World Journal of Gastroenterology2009，15，21： | 4 |
| 16 | Clustering Seismic Activities Using Linear and Nonlinear Discriminant Analysis显示文摘Identification and classification of different seismo-tectonic events with similar characteristics in a region of interest is one of the most important subjects in seismic hazard studies.In this study,linear and nonlinear discriminant analyses have been applied to classify seismic events in the vicinity of Istanbul.The vertical components of the digital velocity seismograms are used for seismic events with magnitude(Md)between 1.8 and 3.0 that occurred between 2001 and 2004.Two,time dependent parameters,complexity and S/P peak amplitude ratio are selected as predictands.Linear,quadratic,diaglinear and diagquadratic discriminant functions are investigated.Accuracy of methods with an additional adjusted quadratic models are 96.6%,96.6%,95.5%,96.6%,and 97.6%,respectively with a various misclassified rate for each class.The performances of models are justified with cross validation and resubstitution error.Although all models remarkably well performed,adjusted quadratic function achieved the best success rate with just 4 misclassified events out of 179,even better compared to complex methods such as,self organizing method,k-means,Gaussion mixture models that applied to same dataset in literature. | H Serdar Kuyuk Eray Yildirim Emrah Dogan Gunduz Horasan | 2014 | Journal of Earth Science2014，25，1： | 4 |
| 17 | 阻塞性睡眠呼吸暂停综合征及持续正压通气治疗对嗓音的影响显示文摘言语的产生有赖于动力器官、振动器官、共鸣器官、构音器官及中枢神经系统的协同整合。多数成人阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)患者存在上气道结构异常,主要表现为软腭肥厚、松弛,咽侧壁肥厚及顺应性增大,双侧扁桃体下极肥大,舌根淋巴组织增生,导致声道共鸣腔的结构改变。 | 杨蕊 王燕 屈季宁 Dogan A | 2017 | 听力学及言语疾病杂志2017，25，2： | 3 |
| 18 | Balance of adiponectin and leptin modulates breast cancer cell growth显示文摘 | Michael E Grossmann Amitabha Ray Soner Dogan Nancy K Mizuno Margot P Cleary | 2008 | Cell Research2008，18，11： | 3 |
| 19 | Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats显示文摘AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced hepatotoxicity.METHODS:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg MTX.Eleven of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control group.Structural and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total bilirubin.RESULTS:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme activities[3.22(2.54-3.62)μmol/g and 69.22(61.13-100.88)U/g,P<0.05 and P<0.01vs model group respectively].CONCLUSION:MTX-induced structural and functional damage to hepatic tissues in rats may involve oxidative stress,and cytoprotective agents(NAC>AMF>ASC)may alleviate MTX hepatotoxicity. | Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 20 | Comparison of contrast sensitivity and visual acuity between deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with keratoconus显示文摘AIM: To evaluate postoperative visual acuity and contrast sensitivity results following deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PK) in patients with keratoconus (KC). METHODS: All the patients' records with KC who had PK or DALK surgery between May 2010 and May 2011 were retrospectively reviewed. Sixty patients who underwent successful corneal transplantation for KC: 30 eyes underwent DALK and 30 eyes underwent PK were included in this study. Preoperative and postoperative mean logarithm of the minimum angle of resolution (logMAR) uncorrected visual acuity (UCVA), logMAR best spectacle-corrected visual acuity (BSCVA) and intraocular pressure (IOP) were evaluated. Contrast sensitivity tests (CS) were done preoperative and 2 months after all sutures had removed. All surgeries were performed under regional anesthesia (retrobulbar anesthesia) by 1 surgeon (B.K.) who was experienced in penetrating and lamellar keratoplasty techniques. RESULTS: The mean age of the DALK group was 29.67±4.95 (range 18-40) years and the PK group was 28.7±3.53 (range 18-39) years. Preoperatively there was no significant difference in the logMAR UCVA, logMAR BSCVA and IOP between the DALK (1.281±0.56; 0.97±0.85; 12.07±2.12mmHg) and PK (1.34±0.21; 0.98±0.21; 13±2.12mmHg) groups. One-year after surgery there was no significant difference in the mean logMAR UCVA and IOP between the DALK (0.46±0.37; 11.73±2.1mmHg) and PK (0.38±0.21; 12±2.12mmHg) groups. The mean contrast sensitivity was evaluated by CC-100 Topcon LCD at 1.5, 2.52, 4.23, 7.10 and 11.91 cycles per degree (cs/deg) spatial frequencies before and 2 months after the all sutures had removed. CONCLUSION: All patients with keratoconus in both DALK and PK groups performed good visual function postoperatively. The mean contrast sensitivity increased considerably at all spatial frequencies compared with preoperative levels in the DALK and PK groups. The mean post-operative evaluation of contrast sensitivity measurements was not significantly different between the two groups. | Mehmet Orcun Akdemir Baran Kandemir Isil Bahar Sayman Cem Selvi OmerKamil Dogan | 2012 | International Journal of Ophthalmology(English edition)2012，5，6： | 3 |
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