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| 1 | 限制性与自由输血策略对心血管疾病患者非心脏手术效果的影响:系统回顾与Meta分析显示文摘目的比较采取限制性与自由输血策略的心血管疾病患者的非心脏手术结局。数据来源搜集涉及医院红细胞输注阈值的随机控制试验。检索CENTRAL、Medline、EMBase、CINAHL、PubMed、LILACS、NHSBT输血证据库、Clinical Trials.gov、WHO国际临床试验注册平台、国际标准随机对照临床试验编号登记、欧盟临床试验登记。检索时间为2015-11-02之前。试验选择选取发表与未发表的比较限制性与自由输血阈值的随机控制试验,试验均纳入心血管疾病患者。结果检索到41项试验,其中7项试验纳入心血管疾病患者。另选取4项纳入心血管疾病患者的试验。最终共搜集11项纳入心血管疾病患者(n=3 033)的试验进行Meta分析(限制性输血1 514例,自由输血1 519例)。输血阈值与30 d死亡率之间联系的汇集风险比例为1.15〔95%CI(0.88,1.50),P=0.50〕,异质性较小(I^2=14%)。限制性输血患者的急性冠脉综合征风险与自由输血患者相比更高〔9项试验;风险比例1.78,95%CI(1.18,2.70),P=0.01,I^2=0%〕。结论对急性冠脉综合征或慢性心血管疾病患者采取80 g/L以下的限制性输血阈值可能并不安全,对病死率与其他结局的影响并不确定。这些数据可暂时支持对急性或慢性心血管疾病患者使用更加自由的输血阈值(>80 g/L),但有待更具有说服力的高质量的心血管疾病患者随机试验进行验证。 | Docherty AB O' Donnell R Brunskill S 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 12 |
| 2 | Identification of a novel glucose transporter-like protein-GLUT-12 显示文摘 | Rogers S Macheda M L Docherty S E | 2002 | Am J Physiol Endocrinol Metab2002，282，3： | 2 |
| 3 | Inhibition of apoptosis after ischemia reperfusion in rat myocardium by cycloheximide显示文摘 | Musat Marcu S Gunter HE Jugdutt BI Docherty JC | | 0，，： | 1 |
| 4 | PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurons via cyclic AMP- protein kinase cascade 显示文摘 | England S Bevan S Docherty RJ | 1996 | J Physiol1996，495，2： | 1 |
| 5 | No evidence for association between BMI and 10 candidate genes at ages 4,7 and 10 in a large UK sample of twins显示文摘 | Haworth CM Butcher LM Docherty S J | | 0，，： | 1 |
| 6 | Identification of a novel glucose transporter like protein GLUT12 显示文摘 | Rogers S Macheda ML Docherty SE Catty MD Henderson MA Sorlier WC | 2002 | Am J Physiol Endocrinol Metab2002，282，3： | 1 |
| 7 | Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth显示文摘 | Pereira J J T Meyer S E Docherty | 2004 | Cancer Res2004，64，3： | 1 |
| 8 | Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24 TNDM) and genotype- phenotype correlation in an intemational cohort of patients 显示文摘 | Docherty LE Kabwama S Lehmann A et at | 2013 | Diabetologia2013，56，4： | 1 |
| 9 | The matrix metalloproteinase sang their natural inhibitors:Prospects fortreating degenerative tissue diseases显示文摘 | Docherty AJ Crabbe T Angal S | 1992 | Trends Biotechnol1992，10，： | 1 |
| 10 | Multiple polymorphisms in genes of the adrenergie stress system confer vulnerability to alcohol abuse显示文摘 | Clarke TK Dempster E Docherty S J | 2012 | Addict Bid2012，17，1： | 1 |
| 11 | Relaxations to beta-adrenoceptor subtype selective agonists in wild-type and NOS-3-KO mouse mesenteric arteries显示文摘 | Zubair K Bexis S Docherty JR | 2008 | Eur J Pharmacol2008，587，13： | 1 |
| 12 | Identification of a novel glucose transporter-like protein-GLUT-12 显示文摘 | Rogers S Macheda ML Docherty SE | 2002 | Am J Physiol Endocrinol Metab2002，282，3： | 1 |
| 13 | Evalua- tion of a discharge education protocol for pediatric patients with gastrostomy tubes 显示文摘 | SCHWEITZER M AUCOIN J DOCHERTY S L | 2014 | J Pediatr Health Care2014，28，5： | 1 |
| 14 | Postural control deficits in participants with functional ankle in- stability as measured by the balance error scoring sys- tem显示文摘 | Docherty C L McLeod T C V Shultz S J | 2006 | Clinical Journal of Sport Medicine2006，16，3： | 1 |
| 15 | Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurons from adult rats 显示文摘 | Docherty RJ Yeats JC Bevan S | 1996 | Pflügers Arch1996，431，6： | 1 |
| 16 | 3D migration velocity analysis using a genetic algorithm显示文摘 | Song Z M Docherty P Singh S C | 1996 | 58th Mtg: Eur Assn Geosci Eng Session1996，，： | 1 |
| 17 | An assessment of ionic liquid mutagenicity using the Ames Test 显示文摘 | Docherty K M Hebbeler S Z Kulpa C F | 2006 | Green Chemistry2006，8，6： | 1 |
| 18 | The marx metalloproteinase and their natural inhibitors:Prospects for treating degenerative tissue diseases显示文摘 | Docherty AJ Crabbe T Angal S | 1992 | Trends Biotechnol1992，10，： | 1 |
| 19 | Identification of a novel glucosetransporter-like protein-GLUT12显示文摘 | Rogers S Macheda ML Docherty SE | 2002 | Am J Physiol2002，282，： | 1 |
| 20 | The matrix metalloproternases and their natural inhibitors:prospects for treating degenerative tissue diseases显示文摘 | Docherty A J Crabbe T Angal S | 2002 | Trends Biotechnol2002，10，8： | 1 |
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