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| 1 | Characterization of meso-scale mechanical properties of Longmaxi shale using grid microindentation experiments显示文摘Mechanical properties,such as the hardness H,Young’s modulus E,creep modulus C,and fracture toughness Kc,are essential parameters in the design of hydraulic fracturing systems for prospective shale gas formations.In this study,a practical methodology is presented for obtaining these properties through microindentation experiments combined with quantitative observations of the mineralogical phases using X-ray diffraction(XRD),scanning electron microscopy(SEM)with backscattered electron(BSE)imaging,and energy-dispersive X-ray spectroscopy(EDS)analyses.We apply this method in the case of three types of Longmaxi shales with different mineralogies(i.e.carbonate-,clay-,and quartz-rich,respectively),which allows us to determine the characteristic indentation depth,hc?8e10 mm,beyond which the mechanical response of the carbonate-rich shale is homogeneous and independent of its complex heterogeneous microstructure.Moreover,exploiting the results of a large number of indentation tests,we demonstrate that the indentation modulus M of the shale increases as a power-law of hardness H,and its creep modulus C increases linearly with H.We also compute the fracture toughness Kc from the indentation data by assuming a perfectly plastic behavior of the sample.Our results are in good agreement with independent measurements of Kc determined by microscratch tests.Finally,further tests on quartz-and clay-rich samples of the Longmaxi shale suggest further variations in the samples’mechanical properties depending on their burial conditions and the mechanical properties of their dominant mineral phases. | Jianting Du Andrew J.Whittle Liming Hu Thibaut Divoux Jay N.Meegoda | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 2 |
| 2 | Normobaric hypoxia induces tolerance to focal cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes,erythropoietin and VEGF in the adult mouse brain显示文摘 | Bernaudin M Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，47： | 1 |
| 3 | TNF receptor I sensitizes neurons to erythropoietin and VEGF-mediated neuroprotection after ischemic and excitotoxic injury显示文摘 | Taoufik E Petit E Divoux D | 2008 | Proc Natl Acad Sci2008，105，16： | 1 |
| 4 | Normobaric hypoxia induces toleranced to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes,erythropoie-tin and VEGF,in the adult mouse brain显示文摘 | Bemaudin M Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，4： | 1 |
| 5 | Optimization of ananimal model of experimental autoimmune encephalo-myelitis achieved with a multiple MOG(35-55)peptide inC57BL6/J strain of mice显示文摘 | Costa O Divoux D Ischenko A | 2003 | J Autoimmun2003，20，1： | 1 |
| 6 | Fibrosis in human adipose tissue:composition,distribution,and link with lipid metabolism and fat mass loss显示文摘 | Divoux A Tordjman J Lacasa D | 2010 | Diebetes2010，59，11： | 1 |
| 7 | Oriented morphology and anisotropic transport in uniaxially stretched perfluorosulfonate ionomer membranes显示文摘 | Park J K Li J Divoux G M | 2011 | Macromolecules2011，44，14： | 1 |
| 8 | Mast cells in human adipose tissue : link with morbid obesity, inflammatory status, and diabetes 显示文摘 | Divoux A Moutel S Poitou C | 2012 | J Clin Endocrinol Metab2012，97，9： | 1 |
| 9 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in asso- ciationwith an increased expression of hypoxia-indueible factor- 1 and itstarget genes, erythropoietin and VEGF, in the adult mouse brain显示文摘 | Bernaudin M Nedelee AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，4： | 1 |
| 10 | TNF receptor I semitizes neurous to erytbropoietin and VEGF-mediated neuroprotection after ischemic and excitotoxic injury显示文摘 | Taoufik B Petit E Divoux D | 2008 | Proc Natl Acad Sci USA2008，105，： | 1 |
| 11 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes,erythropoietin and VEGF,in the adult mouse brain显示文摘 | Bernaudin M Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，： | 1 |
| 12 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes,erythropoietin and VEGF,in the adult mouse brain显示文摘 | Nedelec A Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，： | 1 |
| 13 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes,erythropoietin and VEGF,in the adult mouse brain显示文摘 | Bemaudin M Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，4： | 1 |
| 14 | Integrating multimedia communication into an MMS environment显示文摘 | WU Q DIVOUX T LEPAGE F | 1999 | Computer Communications1999，22，10： | 1 |
| 15 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxin-inducible factor-1 and its target genes,erythropoietin and VEGF,in the adult mouse brain显示文摘 | Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，： | 1 |
| 16 | Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducihle factor-1 and its target genes, erythropoietin and VEGF,in the adult mouse brain显示文摘 | Bernaudin M Nedelec AS Divoux D | 2002 | J Cereb Blood Flow Metab2002，22，4： | 1 |
| 17 | Chemerin Correlates with Markers for Fatty Liver in Morbidly Obese Patients and Strongly Decreases after Weight Loss Induced by Bariatric Surgery显示文摘 | Henrike Sell Adeline Divoux Christine Poitou Arnaud Basdevant Jean-Luc Bouillot Pierre Bedossa Joan Tordjman Jürgen Eckel Karine Clément | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，6： | 1 |
| 18 | TNF receptor I sensitizes neurons to erythropoietinand VEGF-mediated neuroprotection after ischemic and excitotoxic injury显示文摘 | Taoufik E Petit E Divoux D | 2008 | PNAS2008，105，16： | 1 |
| 19 | Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes显示文摘 | Divoux A Moutel S Poitou C | 2012 | J Clin En docrinol Metab2012，97，9： | 1 |
| 20 | Genetic deficiency and pharmacological stabilization of mast cells re- duce diet-induced obesity and diabetes in mice显示文摘 | Liu J Divoux A Sun J | 2009 | Nat Med2009，15，8： | 1 |
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