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| 1 | Vascular endothelial growth factor for the treatment of femoral head osteonecrosis: An experimental study in canines显示文摘AIM To evaluate the treatment of osteonecrosis of the femoral head(ONFH) with the use of vascular endothelial growth factor(VEGF).METHODS In 30 mature beagles(6 groups of 5 beagles) ONFH was induced cryosurgically and one of the following solutions was administered locally in the femoral head(FH) in each group: Single injection of 500 μg VEGF(t-VEGFμ group); single injection of 500 ng VEGF(t-VEGFn group); continuous delivery of 500 μg VEGF through osmotic micropump(t-VEGFpump-μ group); continuous delivery of 500 ng VEGF through osmotic micropump(t-VEGFpump-n group); single injection of 0.9% sodium chloride(t-NS group), while one group that served as control group did not receive any local solution(No-t group). FHs were retrieved 12 wk postoperatively, underwent decalcification and hematoxylin/eosin and toluidine blue staining. In two canines per group, one half of FH was processed without decalcification and stained with modified Masson Trichrome. Histological sections were observed by light microscopy and measured with a semi-automatized bone histomorphometry system and Bone Volume/Total Volume(BV/TV), Marrow Volume/Total Volume(MaV/TV), and Trabecular Thickness(TbT h) were assessed. Standard and robust tests(Welch, Brown Forsythe) of analysis of variance along with multiple comparisons, were carried out among the categories.RESULTS The untreated(No-t) group had signs of osteonecrosis, whereas the VEGF groups revealed reversal of the osteonecrosis. Statistical analysis of the decalcified specimens revealed a significantly better BV/TV ratio and a higher Tb Th between the VEGF treatment groups(except the t-VEGFn group) and the No-t group or the control t-NS group. Single dose 500 μg VEGF group had significantly better BV/TV ratio and higher Tb Th when compared to the No-t group(50.45 ± 6.18 vs 29.50 ± 12.27, P = 0.002 and 151.44 ± 19.07 vs 107.77 ± 35.15, P = 0.161 respectively) and the control t-NS group(50.45 ± 6.18 vs 30.9 ± 6.67, P = 0.004 and 151.44 ± 19.07 vs 107.14 ± 35.71, P = 0.151 respectively). Similar differences were found for the prolonged VEGF delivery/pump groups of 500 μg and 500 ng. Analysis of the totality of specimens(decalcified/non-decalcified) enhanced the aforementioned differences and additionally revealed significant differences in the comparison of the TbT h.CONCLUSION In an experimental model of ONFH in canines it was found that local treatment with VEGF leads to bone tissue remodeling and new bone formation. | Zoe H Dailiana Nikolaos Stefanou Lubna Khaldi Georgios Dimakopoulos James R Bowers Cristian Fink James R Urbaniak | 2018 | World Journal of Orthopedics2018，9，9： | 13 |
| 2 | Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7显示文摘AIM To present the incidence of heterotopic ossification after the use of recombinant human bone morphogenetic protein-7(rhB MP-7) for the treatment of nonunions.METHODS Bone morphogenetic proteins(BMPs) promote bone formation by auto-induction. Recombinant human BMP-7 in combination with bone grafts was used in 84 patients for the treatment of long bone nonunions. All patients were evaluated radiographicaly for the development of heterotopic ossification during the standard assessment for the nonunion healing. In all patients(80.9%) with radiographic signs of heterotopic ossification, a CT scan was performed. Nonunion site palpation and ROM evaluation of the adjacent jointswere also carried out. Factors related to the patient(age, gender), the nonunion(location, size, chronicity, number of previous procedures, infection, surrounding tissues condition) and the surgical procedure(graft and fixation type, amount of rhB MP-7) were correlated with the development of heterotopic ossification and statistical analysis with Pearsons χ~2 test was performed.RESULTS Eighty point nine percent of the nonunions treated with rh BMP-7, healed with no need for further procedures. Heterotopic bone formation occurred in 15 of 84 patients(17.8%) and it was apparent in the routine radiologi-cal evaluation of the nonunion site, in a mean time of 5.5 mo after the rh BMP-7 application(range 3-12). The heterotopic ossification was located at the femur in 8 cases, at the tibia in 6, and at the humerus in οne patient. In 4 patients a palpable mass was present and only in one patient, with a para-articular knee nonunion treated with rhB MP-7, the size of heterotopic ossification affected the knee range of motion. All the patients with heterotopic ossification were male. Statistical analysis proved that patient's gender was the only important factor for the development of heterotopic ossification(P = 0.007). CONCLUSION Heterotopic ossification after the use of rh BMP-7 in nonunions was common but it did not compromise the final clinical outcome in most cases, and affected only male patients. | Marianthi Papanagiotou Zoe H Dailiana Theophilos Karachalios Sokratis Varitimidis Michael Hantes Georgios Dimakopoulos Marianna Vlychou Konstantinos N Malizos | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 3 | A flexible interface design for Web directories to accommodate different cognitive styles 显示文摘 | Chen S Y Magoulas G D Dimakopoulos D | 2005 | Journal of the American Society for Information Science and Technology2005，56，1： | 1 |
| 4 | Modified extra rotator cuff entry point in antegrade humeral nailing 显示文摘 | Dimakopoulos P Papadopoulos AX Papas M | 2005 | Arch Orthop Trauma Surg2005，125，1： | 1 |
| 5 | Operative treatment of displaced greater tuberosity fractures of the proximal humerus显示文摘 | Dimakopoulos P Triantafillopoulos P Papadopoulos AX | 2003 | J Bone Joint Surg Br2003，85，： | 1 |
| 6 | Hysteroscopy in women with abnormal uterine bleeding:a meta-analysis on four major endometrial pathologies 显示文摘 | Gkrozou F Dimakopoulos G Vrekoussis T | 2015 | Arch Gyneeol Obstet2015，291，6： | 1 |
| 7 | A randomized controlled trial of pentoxifylline for the prevention of post-ERCP pancreatitis显示文摘 | Dimitrios Kapetanos Georgios Kokozidis Dimitrios Christodoulou Konstantinos Mistakidis Dimitrios Sigounas Konstantinos Dimakopoulos Georgios Kitis Epaminondas V. Tsianos | 2007 | Gastrointestinal Endoscopy2007，，3： | 1 |
| 8 | Hys- teroscopy in women with abnormal uterine bleeding: a meta-analysis on four major endometrial pathologies 显示文摘 | Gkrozou F Dimakopoulos G Vrekoussis T | 2015 | Arch Gynaecol Obstet2015，291，6： | 1 |
| 9 | Func- tional outcome of surgical treatment for multilevel lumbar spinal stenosis 显示文摘 | Zouboulis P Karageorgos A Dimakopoulos P | 2006 | Aeta Orthop2006，77，4： | 1 |
| 10 | Modified extra rotator-cull entry point in antegrade humeral nailing显示文摘 | Dimakopoulos P Papadopoulos AX Papas M | 2005 | Arch Orthop Trauma Surg2005，125，1： | 1 |
| 11 | Transosseous suture fixation of proximal humeral fractures 显示文摘 | Dimakopoulos P Panagepoulos A Kasimatis G | 2007 | J Bone Jioint Surg Am2007，89，8： | 1 |
| 12 | Tension pneumoperitoneum in association with tension pneumothorax显示文摘 | Zotos PG Kontogiannis AG Dimakopoulos AD | 2012 | Am J Respir Crit Care Med2012，186，12： | 1 |
| 13 | Vertical b-anded gastroplasty versus standard or distal Roux-en-Y gastric bypass based on specific selection criteria in the morbidly obese:preliminary results显示文摘 | Kalfarentzos F Dimakopoulos A Aehagias I | 1999 | Obes Surg1999，9，5： | 1 |
| 14 | Anterior traumatic shoulder dislocation associated with displaced greater tuberosity fracture: the necessity of operative treatment 显示文摘 | Dimakopoulos P Panagopoulos A Kasimatis G et 81 | 2007 | J Orthop Trauma2007，21，2： | 1 |
| 15 | Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t) ide analog therapy starting with lamivudi- ne 显示文摘 | PAPATHEODRIDIS GV DIMOU E DIMAKOPOULOS K | 2005 | Hepatology2005，42，1： | 1 |
| 16 | Functional outcome of surgical treatment for multilevel lumbar spinal stenosis 显示文摘 | Zouboulis P Karaqeorqos A Dimakopoulos P | 2006 | Acta Orthop2006，77，4： | 1 |
| 17 | Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine显示文摘 | Papatheodoridis GV Dimou E Dimakopoulos K | 2005 | Hepatology2005，42，1： | 1 |
| 18 | Vertical banded gastroplasty versus standard or distal Rouxen-Y gastric bypass based on specific selection criteria in the morbidly obese:preliminary results显示文摘 | Kalfarentzos F Dimakopoulos A Kehagias I et a1 | 1999 | Obes Surg1999，9，5： | 1 |
| 19 | A Flexible Interface Design for Web Directories to Accommodate Different Cognitve Styles 显示文摘 | Chen S Y George D M Dimakopoulos D | 2005 | Journal of the American Society for Information Science and Technology2005，56，1： | 1 |
| 20 | Hemiarthrop Ias- ty in the treatment of comminuted intraarticular fractures of the proximal humerus显示文摘 | Dimakopoulos P Potamitis N Lambiris E | 1997 | Clin Orthop Relat Res1997，，341： | 1 |
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