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| 1 | Enhancing endogenous stem cells in the newborn via delayed umbilical cord clamping显示文摘There is currently no consensus among clinicians and scientists over the appropriate or optimal timing for umbilical cord clamping. However, many clinical studies have suggested that delayed cord clamping is associated with various neonatal benefits including increased blood volume, reduced need for blood transfusion, increased cerebral oxygenation in pre-term infants, and decreased frequency of iron deficiency anemia in term infants. Human umbilical cord blood contains significant amounts of stem and progenitor cells and is currently used in the treatment of several life-threatening diseases. We propose that delayed cord clamping be encouraged as it enhances blood flow from the placenta to the neonate, which is accompanied by an increase supply of valuable stem and progenitor cells, as well as may improve blood oxygenation and increase blood volume, altogether reducing the infant's susceptibility to both neonatal and age-related diseases. | Christopher Lawton Sandra Acosta Nate Watson Chiara Gonzales-Portillo Theo Diamandis Naoki Tajiri Yuji Kaneko Paul R.Sanberg Cesar V.Borlongan | 2015 | Neural Regeneration Research2015，10，9： | 6 |
| 2 | Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET显示文摘Background:Alterations in the expression of human kallikrein-related peptidases(KLKs)have been described in patients with Alzheimer’s disease(AD).We elucidated the suitability of KLK6,KLK8 and KLK10 to distinguish AD from NC and explored associations with established AD biomarkers.Methods:KLK levels in cerebrospinal fluid(CSF),as determined by ELISA,were compared between 32 AD patients stratified to A/T/(N)system with evidence for amyloid pathology and of 23 normal controls with normal AD biomarkers.Associations between KLK levels and clinical severity,CSF and positron emission tomography(PET)based AD biomarkers were tested for.Results:Levels of KLK6 and KLK10 were significantly increased in AD.KLK6 differed significantly between AD A+/T+/N+and AD A+/T−/N+or NC with an AUC of 0.922.CSF pTau and tTau levels were significantly associated with KLK6 in AD.Conclusions:KLK6 deserves further investigations as a potential biomarker of Tau pathology in AD. | Oliver Goldhardt Inanna Warnhoff Igor Yakushev Ilijana Begcevic Hans Förstl Viktor Magdolen Antoninus Soosaipillai Eleftherios Diamandis Panagiotis Alexopoulos Timo Grimmer | 2019 | Translational Neurodegeneration2019，8，1： | 3 |
| 3 | Emerging biomarkers for the diagnosis and prognosis of prostate cancer 显示文摘 | Sardana G Dowell B Diamandis EP | 2008 | Clin Chem2008，54，12： | 1 |
| 4 | Proteomic patterns in biological fluids:Do they represent the future of cancer diagnostics 显示文摘 | Eleftherios P Diamandis | 2003 | Clinical Chemistry2003，49，： | 1 |
| 5 | The new human kallikrein gene family : implications in carcinogenesis 显示文摘 | Diamandis E P Yousef G M Luo L Y | 2000 | Trends Endocrinol Metab2000，11，2： | 1 |
| 6 | Distribution of 15 human kallikreins in tis sues and biological luids显示文摘 | Shaw JL Diamandis EP | 2007 | Clin Chem2007，53，8： | 1 |
| 7 | Analysis of serum proteomic patterns for early cancer diagnosis: drawing attention to potential problems 显示文摘 | Diamandis EP | 2004 | J Nat Cancer hast2004，96，5： | 1 |
| 8 | Haman tissue kallikreins:a family of new cancer biomarkers显示文摘 | Diamandis E P Yousef S | | 0，，21： | 1 |
| 9 | Time-resolved immu- nofluorometric assay of alpha-fetoprotein in serum and amni- otic fluid,with a novel detection system显示文摘 | Chan MA Bellem AC Diamandis EP | 1987 | Clin Chem1987，33，： | 1 |
| 10 | Mass spectrometry as a diagnostic and a cancer biomarker discovery tool: opportunities and potential limitations 显示文摘 | Diamandis EP | 2004 | Mol Cell Proteomics2004，3，4： | 1 |
| 11 | Assay of prostate - specific antigen from whole blood spotted on filter paper and application to prostate cancer screening 显示文摘 | Hoffman BR Yu H Diamandis EP | 1996 | Clin Chem1996，42，： | 1 |
| 12 | The red wine phenolics trans-resveratrol and quercetin block human plate- let aggregation and eicosanoid synthesis: Implications for protec- tion against coronary heart disease 显示文摘 | PACE-ASCIAK CR HAHN S DIAMANDIS EP | 1995 | Clin Chim Acta1995，235，2： | 1 |
| 13 | The human kallikrein gene family-implication in carcinogenesis显示文摘 | Diamandis E P Yousef G M Luo L Y | 2000 | Trends Endocrinol Metab2000，11，1： | 1 |
| 14 | Plasma protein profiling by mass spectrometry for cancer diagnosis: opportunities and limitations 显示文摘 | Diamandis EP van der Merwe DE | 2005 | Clin Cancer Res2005，11，3： | 1 |
| 15 | Emerging biomarkersfor the diagnosis and prognosis of prostate cancer显示文摘 | Sardana G Dowell B Diamandis EP | 2008 | ClinChem2008，54，12： | 1 |
| 16 | Utility of kallikrein-related pep- tidases ( KLKs ) as cancer biomarkers 显示文摘 | Emami N Diamandis EP | 2008 | C lin Chem2008，54，： | 1 |
| 17 | The normal epithelial cell-specific(NSE1) gene is up-regulated by steroid hormones in the breast carcinoma cell line BT-474显示文摘 | Luo LY Grass L Diamandis EP | 2000 | Anticancer Res2000，20，2： | 1 |
| 18 | Identification and molecular characterization of a novel member of the singlec family显示文摘 | Foussias G Yousef G M Diamandis E P | 2000 | Genomics2000，67，1： | 1 |
| 19 | Human tissue kallikreins: a family of new cancer biomarkers显示文摘 | Diamandis EP Yousef GM | 2002 | Clin Chem2002，48，8： | 1 |
| 20 | Human tissue kallikreins:a family of new cancer biomarkers显示文摘 | Diamandis EP Yousef GM | 2002 | Clin Chem2002，48，8： | 1 |
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